Physical inactivity is a recognized modifiable risk factor for Alzheimer’s disease (AD), yet its relationship with progression of AD pathology in humans remains unclear, limiting the effective translation into prevention trials. Using pedometer-measured step counts in cognitively unimpaired older adults, we demonstrated an association between higher physical activity and slower cognitive and functional decline in… Continue reading Physical #activity as a modifiable risk factor in preclinical #Alzheimer’s disease
Tag: steps
Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
To examine the dose-response associations of step count and stepping intensity with risk of cardiovascular mortality and incidence of heart failure (HF), myocardial infarction (MI), and stroke (major adverse cardiovascular events, MACE) in people with hypertension.Methods and resultsData were obtained from participants with established hypertension from the UK Biobank accelerometry sub-study. Participants wore a wrist-worn… Continue reading Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
BackgroundDespite the rapid increase in evidence from the past decade on daily steps and health-related outcomes, existing systematic reviews primarily focused on few outcomes, such as all-cause mortality. This study synthesised the prospective dose-response relationship between daily steps and health outcomes including all-cause mortality, cardiovascular disease, cancer, type 2 diabetes, cognitive outcomes, mental health outcomes,… Continue reading Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
Relationship of Daily #Step Counts to All-Cause #Mortality and #Cardiovascular Events
Background The minimal and optimal daily step counts for health improvements remain unclear. Objectives A meta-analysis was performed to quantify dose-response associations of objectively measured step count metrics in the general population. Methods Electronic databases were searched from inception to October 2022. Primary outcomes included all-cause mortality and incident cardiovascular disease (CVD). Study results were… Continue reading Relationship of Daily #Step Counts to All-Cause #Mortality and #Cardiovascular Events
Association of Daily Step Patterns With Mortality in US Adults
Importance Previous studies have shown that individuals who regularly walk, particularly 8000 daily steps or more, experience lower mortality. However, little is known about the health benefits of walking intensively only a few days a week.Objective To evaluate the dose-response association between the number of days an individual takes 8000 steps or more and mortality… Continue reading Association of Daily Step Patterns With Mortality in US Adults
Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis
Taking fewer than the widely promoted “10 000 steps per day” has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose–response relationship between steps per day and CVD can help inform clinical and public health guidelines.METHODS:Eight prospective studies (20 152… Continue reading Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis
Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality
Recommendations for the number of steps per day may be easier to enact for some people than the current time- and intensity-based physical activity guidelines, but the evidence to support steps-based goals is limited.Objective To describe the associations of step count and intensity with all-cause mortality and cancer and cardiovascular disease (CVD) incidence and mortality.Design, Setting,… Continue reading Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality
Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK
Key PointsQuestion Is there a dose-response association of daily step count and intensity with incidence of all-cause dementia among adults living in the UK?Findings This cohort study of adults assessed with wrist-worn accelerometers found that accruing more steps per day was associated with steady declines in dementia incidence risk, up to 9800 steps per day, beyond which… Continue reading Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK
Low Daily Step Count Is Associated With a High Risk of Hospital Admission and Death in Community-Dwelling Patients With Cirrhosis
Background & AimsDaily step count measures cardiorespiratory fitness and has been associated with clinical outcomes. However, its utility in patients with cirrhosis remains largely unexplored. We aimed to investigate the association between step count, frailty metrics, and clinical outcomes in cirrhosis.MethodsAll participants underwent frailty evaluation with the liver frailty index, 6-minute walk test, and gait… Continue reading Low Daily Step Count Is Associated With a High Risk of Hospital Admission and Death in Community-Dwelling Patients With Cirrhosis
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