Chronic kidney disease (CKD) is a devastating progressive condition accompanied with high morbidity and mortality rates. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have recently proven their renoprotective effects, whereas evidence for metformin remains limited but suggestive of potential benefit. This study aimed at comparing the efficacy and safety of metformin versus empagliflozin, a SGLT2 inhibitor, on retarding… Continue reading Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
Tag: metformin
Effect of #Metformin on the Risk of Post- #coronavirus Disease 2019 Condition Among Individuals With #Overweight or #Obese: A Population-based Retrospective Cohort Study
BackgroundA subgroup analysis of the COVID-OUT trial's long-term outcome found that starting metformin within 3 days of coronavirus disease 2019 (COVID-19) diagnosis reduced post–COVID-19 condition (PCC) incidence by 63% in overweight or obese individuals. However, its generalizability remains uncertain.ObjectivesTo evaluate the effectiveness of metformin in preventing PCC in adults with overweight or obesity who had… Continue reading Effect of #Metformin on the Risk of Post- #coronavirus Disease 2019 Condition Among Individuals With #Overweight or #Obese: A Population-based Retrospective Cohort Study
#Rapamycin, Not #Metformin, Mirrors #Dietary Restriction-Driven #Lifespan Extension in Vertebrates: A Meta-Analysis
Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long-term DR is difficult to maintain, leading to the search for compounds that regulate metabolism and increase lifespan without reducing caloric intake. The magnitude of lifespan extension from two such compounds, rapamycin and metformin, remains inconclusive, particularly in vertebrates. Here, we conducted a meta-analysis… Continue reading #Rapamycin, Not #Metformin, Mirrors #Dietary Restriction-Driven #Lifespan Extension in Vertebrates: A Meta-Analysis
#Metformin decelerates #aging clock in male monkeys
Highlights•Metformin prevents brain atrophy, elevating cognitive function in aged male primates.Metformin slows the pace of aging across diverse male primate tissues•Metformin counterparts neuronal aging, delivering geroprotection via Nrf2 in male primatesSummaryIn a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The… Continue reading #Metformin decelerates #aging clock in male monkeys
#Gout risk in adults with pre-#diabetes initiating metformin
Objective Despite the strong association between gout and pre-diabetes, the role of metformin in gout among individuals with pre-diabetes remains uncertain. We compared the incidence rates of gout in adults with pre-diabetes starting metformin with those not using antidiabetic treatments.Methods We conducted a new-user, propensity score-matched cohort study using electronic health records from an academic health system… Continue reading #Gout risk in adults with pre-#diabetes initiating metformin
Lac-Phe mediates the effects of #metformin on #food intake and body weight
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. Here, we show that metformin is a powerful pharmacological inducer of the anorexigenic metabolite N-lactoyl-phenylalanine (Lac-Phe) in cells, in mice and two independent human cohorts. Metformin drives Lac-Phe biosynthesis through… Continue reading Lac-Phe mediates the effects of #metformin on #food intake and body weight
#Metformin and Its Benefits for Various Diseases
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability to decrease plasma glucose levels. Over time, different uses of metformin were discovered, and the benefits of metformin for… Continue reading #Metformin and Its Benefits for Various Diseases
Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
Metformin, a first-line medication for type 2 diabetes, might also have a protective effect against ageing-related diseases, but so far little experimental evidence is available. We sought to assess the target-specific effect of metformin on biomarkers of ageing in the UK Biobank.MethodsIn this drug target mendelian randomisation study, we assessed the target-specific effect of four… Continue reading Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
Development of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a Sulfonylurea
Metformin may have a protective association against developing osteoarthritis (OA), but robust epidemiological data are lacking.Objective To determine the risk of OA and joint replacement in individuals with type 2 diabetes treated with metformin compared with a sulfonylurea.Design, Setting, and Participants This retrospective cohort study used claims data from the Optum deidentified Clinformatics Data Mart… Continue reading Development of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a Sulfonylurea
2 Medical News 