Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 in adult mice depressed physical performance. Muscle microvascular endothelial cell apoptosis and capillary rarefaction were evident and sufficient to account for the… Continue reading Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity
Tag: Exercise
Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
Randomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's disease, but the underlying neural mechanisms are unclear. Here, we investigated how aerobic exercise influences disease-related functional and structural changes in the cortico-striatal sensorimotor network, which is involved in the emergence of motor deficits in Parkinson's disease. Additionally, we explored effects… Continue reading Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands
Moderate to vigorous physical activity (MVPA) is strongly associated with risk reductions of noncommunicable diseases and mortality. Cardiovascular health status may influence the benefits of MVPA. We compare the association between MVPA and incident major adverse cardiovascular events (MACE) and mortality between healthy individuals, individuals with elevated levels of cardiovascular risk factors (CVRF), and cardiovascular… Continue reading Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands
Microglial correlates of late life physical activity: Relationship with synaptic and cognitive aging in older adults
Physical activity relates to reduced dementia risk, though the cellular and molecular mechanisms are unknown. We translated animal and in-vitro studies demonstrating a causal link between physical activity and microglial homeostasis into humans. Decedents from Rush MAP completed actigraphy monitoring (average daily activity) and cognitive evaluation in life, and neuropathological examination at autopsy. Brain tissue… Continue reading Microglial correlates of late life physical activity: Relationship with synaptic and cognitive aging in older adults
The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids
The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role in energy homeostasis and the development of metabolic disorders being a mediator in the relationship between the gut microbiota and host metabolism. In the current study we explore the functional interactions between the endocannabinoid system and the gut microbiome in… Continue reading The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids
Effects of #Lifestyle Modification on Patients With Resistant #Hypertension: Results of the TRIUMPH Randomized Clinical Trial
#Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory #Dance Learning over 3-Years: A Preliminary Longitudinal Investigation
Parkinson’s disease (PD) is a neurodegenerative disease that has a fast progression of motor dysfunction within the first 5 years of diagnosis, showing an annual motor rate of decline of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) between 5.2 and 8.9 points. We aimed to determine both motor and non-motor PD symptom… Continue reading #Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory #Dance Learning over 3-Years: A Preliminary Longitudinal Investigation
#Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood #Pressure or #Cholesterol: Who, What, and How?: A Scientific Statement From the American Heart Association
Current guidelines published by the American Heart Association and the American College of Cardiology broadly recommend lifestyle approaches to prevent and treat elevated blood pressure and cholesterol. For patients with mildly or moderately elevated blood pressure and blood cholesterol, lifestyle-only approaches are the first line of therapy. The purpose of this scientific statement is to:… Continue reading #Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood #Pressure or #Cholesterol: Who, What, and How?: A Scientific Statement From the American Heart Association
The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
To provide a novel overview of the literature and to summarise the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in stroke survivors. Data SourceWe conducted a systematic review and searched MEDLINE, EMBASE and Cochrane CENTRAL using terms related to AE, neuroplasticity, brain repair, and stroke. Study SelectionTitles,… Continue reading The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
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