In type 2 diabetes, insulin resistance and progressive β-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic… Continue reading Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 #Diabetes Consuming a Three- #Meal Diet: A Randomized Clinical Trial
Tag: Diabetes
Maternal #diabetes during pregnancy and early onset of #cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
To evaluate the associations between maternal diabetes diagnosed before or during pregnancy and early onset cardiovascular disease (CVD) in offspring during their first four decades of life. ..Offspring of mothers with diabetes had a 29% increased overall rate of early onset CVD (hazard ratio 1.29 (95% confidence interval 1.21 to 1.37); cumulative incidence among offspring… Continue reading Maternal #diabetes during pregnancy and early onset of #cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
Prevalence of #Prediabetes Among #Adolescents and Young Adults in the United States, 2005-2016
.. Impaired fasting glucose was defined as fasting plasma glucose of 100 mg/dL to less than 126 mg/dL, IGT as 2-hour plasma glucose of 140 mg/dL to less than 200 mg/dL, and increased HbA1c level as HbA1c level between 5.7% and 6.4%. The prevalence of IFG, isolated IFG, IGT, isolated IGT, increased HbA1c level, isolated… Continue reading Prevalence of #Prediabetes Among #Adolescents and Young Adults in the United States, 2005-2016
Adjunctive #Rifampin Therapy For Diabetic Foot #Osteomyelitis in the Veterans Health Administration
Among patients diagnosed with diabetes, the lifetime incidence of foot ulcers is 15%. Infection is a common complication of foot ulcers, and 20% to 60% of infections result in diabetic foot osteomyelitis (DFO). ..Patients initiating rifampin therapy within 6 weeks of the DFO diagnosis and receiving the drug for at least 14 days within 90… Continue reading Adjunctive #Rifampin Therapy For Diabetic Foot #Osteomyelitis in the Veterans Health Administration
#Obesity Is the Most Common Risk Factor for Chronic #liver Disease
Obesity has been associated with liver fibrosis, yet guidelines do not emphasize it as an independent risk factor in which to have a high index of suspicion of advanced disease.. ..We prospectively recruited patients from a primary care practice with hazardous alcohol use and/or type 2 diabetes and/or obesity. Subjects were invited for a transient… Continue reading #Obesity Is the Most Common Risk Factor for Chronic #liver Disease
Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life Evidence From a British Birth Cohort
Office-based Framingham Heart study–cardiovascular risk scores (FHS-CVS) were derived at ages 36, 53, and 69 years using systolic blood pressure, antihypertensive medication usage, smoking, diabetic status, and body mass index. Analysis models adjusted for age at imaging, sex, APOE genotype, socioeconomic position, and, where appropriate, total intracranial volume. ..At all points, these scores were associated… Continue reading Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life Evidence From a British Birth Cohort
Changes in Consumption of Sugary Beverages and Artificially #Sweetened Beverages and Subsequent Risk of Type 2 #Diabetes: Results From Three Large Prospective U.S. Cohorts of Women and Men
artificially sweetened beverages (ASBs) ..After adjustment for BMI and initial and changes in diet and lifestyle covariates, increasing total sugary beverage intake (including both sugar-sweetened beverages and 100% fruit juices) by >0.50 serving/day over a 4-year period was associated with a 16% (95% CI 1%, 34%) higher diabetes risk in the subsequent 4 years. Increasing… Continue reading Changes in Consumption of Sugary Beverages and Artificially #Sweetened Beverages and Subsequent Risk of Type 2 #Diabetes: Results From Three Large Prospective U.S. Cohorts of Women and Men
Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case–control study
When adjusting for potential confounders, AD use was associated with an increased risk of GDM (aOR 1.19, 95% CI 1.08 to 1.30); venlafaxine (aOR 1.27, 95% CI 1.09 to 1.49) and amitriptyline (aOR 1.52, 95% CI 1.25 to 1.84) were also associated with an increased risk of GDM. Moreover, the risk of GDM was increased with longer duration… Continue reading Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case–control study
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