BACKGROUND:Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk factors throughout their life span has been limited. This prospective cohort study aims to determine the effect of body mass index (BMI) and its changes in adolescence and young adulthood on early onset cerebrovascular disease.METHODS:This study includes 10 491 people (5185… Continue reading #Overweight in #Adolescence and Young Adulthood in Association With Adult #Cerebrovascular Disease: The NFBC1966 Study
Tag: CVD
Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
Insight into associations between the gut microbiome with metabolism and aging is crucial for tailoring interventions to promote healthy longevity. In a discovery cohort of 10,207 individuals aged 40–93 years, we used 21 metabolic parameters to classify individuals into five clusters, termed metabolic multimorbidity clusters (MCs), that represent different metabolic subphenotypes. Compared to the cluster classified… Continue reading Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
#Atherosclerotic #Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations
Key PointsQuestion How do estimates of 10-year atherosclerotic cardiovascular disease (ASCVD) risk and recommendations for primary prevention statin therapy differ between the 2023 American Heart Association (AHA) Predicting Risk of Cardiovascular Disease Events (PREVENT) equations and the 2013 AHA/American College of Cardiology pooled cohort equations (PCEs)?Findings In this cross-sectional study of 3785 adults aged 40 to 75… Continue reading #Atherosclerotic #Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations
Ultra-processed #food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses
AbstractObjective To evaluate the existing meta-analytic evidence of associations between exposure to ultra-processed foods, as defined by the Nova food classification system, and adverse health outcomes.Design Systematic umbrella review of existing meta-analyses.Data sources MEDLINE, PsycINFO, Embase, and the Cochrane Database of Systematic Reviews, as well as manual searches of reference lists from 2009 to June 2023.Eligibility criteria for… Continue reading Ultra-processed #food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses
Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
There is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
A terminal metabolite of niacin promotes vascular inflammation and contributes to #cardiovascular disease risk
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD risk remains even for individuals receiving all guideline-recommended interventions. Niacin is an essential micronutrient fortified in food staples, but its role in CVD is not well understood. In this study, untargeted metabolomics analysis of fasting plasma from stable cardiac patients in a prospective discovery cohort… Continue reading A terminal metabolite of niacin promotes vascular inflammation and contributes to #cardiovascular disease risk
Long-term risk of #cardiovascular disease after traumatic #brain injury: screening and prevention
Traumatic brain injury (TBI) is highly prevalent among individuals participating in contact sports, military personnel, and in the general population. Although it is well known that brain injury can cause neurological and psychiatric complications, evidence from studies on individuals exposed to a single or repetitive brain injuries suggests an understudied association between TBI and the… Continue reading Long-term risk of #cardiovascular disease after traumatic #brain injury: screening and prevention
Abstract 13719: Minimal and Delayed Age-Related Increase of Arterial #Stiffness Among Tsimane Forager-Horticulturalists
Background: Tsimane forager-farmers of the Bolivian Amazon exhibit a distinct trajectory of vascular aging, characterized by low age-related increases in BP, the lowest levels of coronary calcification ever reported, and robust VO2 max. However, the prevalence of arterial stiffness (ArSt) in this population and its association with age and other cardiovascular risk factors are unknown.Methods: Large artery elasticity… Continue reading Abstract 13719: Minimal and Delayed Age-Related Increase of Arterial #Stiffness Among Tsimane Forager-Horticulturalists
Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
Dietary circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohortDaily eating/fasting cycles synchronise circadian peripheral clocks, involved in the regulation of the cardiovascular system. However, the associations of daily meal and fasting timing with cardiovascular disease (CVD) incidence remain unclear. We used data from 103,389 adults in the NutriNet-Santé study. Meal timing and… Continue reading Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
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