Since the late 1980s, global antibiotic consumption and colorectal cancer (CRC) rates in those aged less than 50 years have soared. As the gut microbiome modulates many human processes, significantly altering microbiome structure and diversity with antibiotic therapy has previously been shown to influence CRC genesis in older adults. To our knowledge, no study before… Continue reading SO-25 Global rise in early-onset #colorectal cancer: An association with #antibiotic consumption?
Tag: cancer
#Proton pump inhibitors and risk of #colorectal cancer
To determine whether proton pump inhibitors (PPIs) are associated with an increased risk of colorectal cancer, compared with histamine-2 receptor antagonists (H2RAs). Design The United Kingdom Clinical Practice Research Datalink was used to identify initiators of PPIs and H2RA from 1990 to 2018, with follow-up until 2019. Cox proportional hazards models were fit to estimate… Continue reading #Proton pump inhibitors and risk of #colorectal cancer
Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
Highlights•n-3 and n-6 PUFAs preferentially accumulate in lipid droplets of acidic cancer cells •Excess LC-PUFAs undergo peroxidation and induce ferroptosis in acidic cancer cells •DGAT inhibitors prevent the formation of lipid droplets and promote ferroptosis •DGATi enhance the tumor growth inhibitory effects of dietary n-3 LC-PUFAs in mice SummaryTumor acidosis promotes disease progression through a… Continue reading Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
#Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial
Few pharmacological interventions are available for cancer-associated anorexia and cachexia. Mirtazapine has been suggested for use in cancer-associated anorexia and cachexia. ObjectivesThis study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia. MethodsA double-blind placebo-controlled randomized trial. The study included 120 incurable solid tumour patients with anorexia (appetite loss… Continue reading #Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial
#Thyroid dysfunction and #breast cancer risk among women in the UK Biobank cohort
This study aimed to evaluate the association between thyroid dysfunction and breast cancer risk. We included 239,436 females of the UK Biobank cohort. Information on thyroid dysfunction, personal and family medical history, medications, reproductive factors, lifestyle, and socioeconomic characteristics was retrieved from baseline self-reported data and hospital inpatient databases. Breast cancer diagnoses were identified through… Continue reading #Thyroid dysfunction and #breast cancer risk among women in the UK Biobank cohort
Nongenetic Determinants of Risk for Early-Onset #Colorectal Cancer
Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by… Continue reading Nongenetic Determinants of Risk for Early-Onset #Colorectal Cancer
Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
Prospective evidence on associations between diet quality indices and lung cancer risk is limited, particularly among older women. ObjectivesWe investigated associations between 4 diet quality indices [Healthy Eating Index-2015 (HEI-2015), Alternate Healthy Eating Index 2010 (AHEI-2010), alternate Mediterranean Diet (aMED), and Dietary Approaches to Stop Hypertension (DASH)] and lung cancer incidence and mortality in the… Continue reading Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
NOX4 links metabolic regulation in #pancreatic #cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
There is an urgent need to identify vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). PDAC cells acquire metabolic changes that augment NADPH production and cytosolic redox homeostasis. Here, we show that high NADPH levels drive activity of NADPH oxidase 4 (NOX4) expressed in the endoplasmic reticulum (ER) membrane. NOX4 produces H2O2 metabolized by peroxiredoxin 4 (PRDX4)… Continue reading NOX4 links metabolic regulation in #pancreatic #cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
#Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset #colorectal cancer among women
Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined. Design In the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake… Continue reading #Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset #colorectal cancer among women
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