Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has released the 2020 Asthma Guideline Update with updated evidence-based recommendations for treatment of patients with asthma.. ..From 20 572 identified references, 475 were included in the… Continue reading Managing #Asthma in Adolescents and Adults 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program
Tag: asthma
Multimorbidity in #asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2LEN study
..Subjects with asthma, rhinitis and eczema were more likely to be sensitised to seasonal allergens (67 vs 32%, p<0.001), food allergens (54 vs. 18%, p<0.001) and to have a higher degree of sensitisation than subjects with only asthma (23 vs 10%, p<0.001). Subjects with allergic multimorbidity more often had allergic reactions to food (28 vs… Continue reading Multimorbidity in #asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2LEN study
#Emergency Visits for #Thunderstorm-Related Respiratory Illnesses Among Older Adults
Thunderstorm-related atmospheric changes are expected to increase in severity with rising global temperatures. Although large-scale evidence is limited, vulnerable populations, such as older adults or those with common chronic respiratory diseases, like asthma or chronic obstructive pulmonary disease (COPD), are expected to be susceptible to negative health effects from these changes.The objective of this study… Continue reading #Emergency Visits for #Thunderstorm-Related Respiratory Illnesses Among Older Adults
American Academy of Pediatrics – Section on Pediatric #Pulmonology and #Sleep Medicine
1. Avoid stepping up asthma therapy (adding new drugs or going to higher doses) before assessing adherence, appropriateness of device, and technique with current asthma medications. 2. Do not use LABA/steroid combination drugs as initial therapy for intermittent or mild persistent asthma. 3. Avoid administering nebulized medications by “blow by,” or placing the mask or… Continue reading American Academy of Pediatrics – Section on Pediatric #Pulmonology and #Sleep Medicine
Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro
Potential drug treatments for Alzheimer’s disease (AD) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and cell death. Here, a small library of structurally diverse compounds was screened in vitro for the ability to inhibit tau aggregation, using high-throughput synchrotron radiation… Continue reading Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro
Associations of #sleep duration with patient-reported outcomes and healthcare use in U.S. adults with #asthma
..Asthma was identified by self-report. Habitual hours of sleep duration were categorized as short (≤5), normal (6-8), and long (≥9). Multivariate regression analyses were used to examine the associations between sleep duration and patient-reported outcomes and healthcare use. Results Of the 1389 adults with asthma, 26% reported short sleep duration, 66% reported normal sleep duration,… Continue reading Associations of #sleep duration with patient-reported outcomes and healthcare use in U.S. adults with #asthma
Sputum #microbiome profiles identify severe #asthma phenotypes of relative stability at 12-18 months
..Data were available for 100 severe asthma subjects (median age: 55 yrs, 42% males). Two microbiome-driven clusters were identified, characterized by differences in asthma onset, smoking status, residential locations, percentage of blood and/or sputum neutrophils and macrophages, lung spirometry, and concurrent asthma medications (all p-values <.05). Cluster 2 patients displayed a commensal-deficient bacterial profile which… Continue reading Sputum #microbiome profiles identify severe #asthma phenotypes of relative stability at 12-18 months
Persistent #Asthma is Associated with Increased Risk for Incident Atrial #Fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA)
Asthma and atrial fibrillation (AF) share an underlying inflammatory pathophysiology. We hypothesized that persistent asthmatics are at higher risk for developing AF and that this association would be attenuated by adjustment for baseline markers of systemic inflammation. ..Persistent asthma was defined as asthma requiring use of controller medications. Intermittent asthma was defined as asthma without… Continue reading Persistent #Asthma is Associated with Increased Risk for Incident Atrial #Fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA)
Sex Steroid #Hormones and #Asthma in a Nationwide Study of U.S. Adults
Women have a higher burden of asthma than men. Although sex hormones may explain sex differences in asthma, their role is unclear.. ..Free testosterone levels in the fourth quartile were associated with lower odds of current asthma in women (odds ratio [OR] for the fourth quartile [Q4] vs. Q1, 0.56; 95% confidence interval [CI], 0.39–0.80).… Continue reading Sex Steroid #Hormones and #Asthma in a Nationwide Study of U.S. Adults
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