Highlights•Most eligible people offered participation in an aspirin trial accepted. •Among participants, most reported high (≥80%) adherence on a day-to-day basis. •No studies examined uptake and adherence in routine care. •Further research is needed to identify the barriers to using aspirin in practice. AbstractWe undertook a systematic review to synthesise the data on attitudes and… Continue reading Aspirin use for cancer prevention: A systematic review of public, patient and healthcare provider attitudes and adherence behaviours
Tag: Aspirin
Enteric-Coated #Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
Aspirin appeared as a medicine to deal with aches and inflammation, but due to its antiplatelet properties, it has evolved into a drug mainly used to avert cardiovascular disease. Regardless of its therapeutic uses, the limiting aspect for aspirin use has been its affiliation with gastrointestinal (GI) toxicity, classifying from acute mucosal damage to GI… Continue reading Enteric-Coated #Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
Comparative Effectiveness of #Aspirin Dosing in #Cardiovascular Disease
The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy. METHODSUsing an open-label, pragmatic design, we randomly assigned patients with established atherosclerotic cardiovascular disease to a strategy of 81 mg or 325 mg… Continue reading Comparative Effectiveness of #Aspirin Dosing in #Cardiovascular Disease
#Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With #Coronavirus Disease 2019
Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality. METHODS: A retrospective, observational cohort study of adult patients admitted with COVID-19 to multiple… Continue reading #Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With #Coronavirus Disease 2019
Major GI #bleeding in older persons using #aspirin: incidence and risk factors in the ASPREE randomised controlled trial
There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial. Design Data were extracted from an aspirin versus placebo primary prevention trial conducted throughout 2010–2017 (‘ASPirin in Reducing Events in the Elderly… Continue reading Major GI #bleeding in older persons using #aspirin: incidence and risk factors in the ASPREE randomised controlled trial
#Ticagrelor Added to #Aspirin in Acute Ischemic #Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
Reduction of subsequent disabling stroke is the main goal of preventive treatment in the acute setting after transient ischemic attack (TIA) or minor ischemic stroke. Objective To evaluate the superiority of ticagrelor added to aspirin in preventing disabling stroke and to understand the factors associated with recurrent disabling stroke. Design, Setting, and Participants The Acute… Continue reading #Ticagrelor Added to #Aspirin in Acute Ischemic #Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
2021 The Effect of Preconception-Initiated Low-Dose #Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, #Pregnancy Loss, and Live Birth
A previous large randomized trial indicated that preconception-initiated low-dose aspirin (LDA) therapy did not have a positive effect on pregnancy outcomes. However, this trial was subject to nonadherence, which was not taken into account by the intention-to-treat approach.. ..Relative to placebo, adhering to LDA for 5 of 7 days per week led to 8 more… Continue reading 2021 The Effect of Preconception-Initiated Low-Dose #Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, #Pregnancy Loss, and Live Birth
#Ticagrelor Added to #Aspirin in Acute Ischemic #Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
Reduction of subsequent disabling stroke is the main goal of preventive treatment in the acute setting after transient ischemic attack (TIA) or minor ischemic stroke.. ..Ticagrelor (180-mg loading dose on day 1 followed by 90 mg twice daily for days 2-30) or placebo within 24 hours of symptom onset. All patients received aspirin, 300 to… Continue reading #Ticagrelor Added to #Aspirin in Acute Ischemic #Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
#ASPIRIN AND THE RISK OF NON‐DIGESTIVE TRACT CANCERS: AN UPDATED META‐ANALYSIS TO 2019
Aspirin has been associated to a reduced risk of colorectal and other selected digestive tract cancers, but the evidence other neoplasms is still controversial. In order to provide an up‐to‐date quantification of the role of aspirin on lung, breast, endometrium, ovary, prostate, bladder, and kidney cancer, we conducted a systematic review and meta‐analysis of all… Continue reading #ASPIRIN AND THE RISK OF NON‐DIGESTIVE TRACT CANCERS: AN UPDATED META‐ANALYSIS TO 2019
2 Medical News 