As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from the Nurses’ Health Study (1986–2016) and the Health Professionals Follow-Up Study (1986–2016), we examined the association of long-term adherence to eight dietary patterns and ultraprocessed food consumption with healthy… Continue reading Optimal #dietary patterns for healthy #aging
Tag: Ageing
Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
Importance Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health.Objective To ascertain how longitudinal changes in diet quality and WHR during midlife are associated with hippocampal connectivity and cognitive function in… Continue reading Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
Suboptimal #dietary patterns are associated with accelerated biological #aging in young adulthood: A study with twins
Background & aimsSuboptimal diets increase morbidity and mortality risk. Epigenetic clocks are algorithms that can assess health and lifespan, even at a young age, before clinical manifestations of diseases. We investigated the association between dietary patterns and biological aging in young adult twins.MethodsThe data were drawn from the population-based FinnTwin12 study and consisted of twins… Continue reading Suboptimal #dietary patterns are associated with accelerated biological #aging in young adulthood: A study with twins
Impact of different types of physical #exercise on sleep quality in older population with #insomnia: a systematic review and network meta-analysis of randomised controlled trials
Objective To measure the impact of each type of exercise on sleep quality and identify the exercise that enhances sleep quality the most.Study selection Eligible randomised controlled trials that compare physical exercise to routine activities, usual care, non-physical activity, or health education to measure the Pittsburgh Sleep Quality Index.Data source Studies retrieved from Medline, Embase,… Continue reading Impact of different types of physical #exercise on sleep quality in older population with #insomnia: a systematic review and network meta-analysis of randomised controlled trials
Integrating the #environmental and genetic architectures of #aging and mortality
Both environmental exposures and genetics are known to play important roles in shaping human aging. Here we aimed to quantify the relative contributions of environment (referred to as the exposome) and genetics to aging and premature mortality. To systematically identify environmental exposures associated with aging in the UK Biobank, we first conducted an exposome-wide analysis… Continue reading Integrating the #environmental and genetic architectures of #aging and mortality
Individual and additive effects of vitamin #D, #omega-3 and #exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per… Continue reading Individual and additive effects of vitamin #D, #omega-3 and #exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Suboptimal dietary patterns are associated with accelerated biological #aging in young adulthood: A study with twins
Suboptimal diets increase morbidity and mortality risk. Epigenetic clocks are algorithms that can assess health and lifespan, even at a young age, before clinical manifestations of diseases. We investigated the association between dietary patterns and biological aging in young adult twins. MethodsThe data were drawn from the population-based FinnTwin12 study and consisted of twins aged… Continue reading Suboptimal dietary patterns are associated with accelerated biological #aging in young adulthood: A study with twins
Subcellular #NAD+ pools are interconnected and buffered by mitochondrial NAD+
The coenzyme NAD+ is consumed by signalling enzymes, including poly-ADP-ribosyltransferases (PARPs) and sirtuins. Ageing is associated with a decrease in cellular NAD+ levels, but how cells cope with persistently decreased NAD+ concentrations is unclear. Here, we show that subcellular NAD+ pools are interconnected, with mitochondria acting as a rheostat to maintain NAD+ levels upon excessive… Continue reading Subcellular #NAD+ pools are interconnected and buffered by mitochondrial NAD+
Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms
Highlights•The regular consumption of moderate doses of coffee attenuates all-cause mortality•Coffee intake attenuates age-associated diseases (cardiovascular, stroke, cancer)•Coffee and its main components (caffeine, chlorogenic acids) control stress adaptation•Coffee intake preserves the main biological mechanisms of aging AbstractThe conception of coffee consumption has undergone a profound modification, evolving from a noxious habit into a safe lifestyle… Continue reading Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms
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