Research studies have observed associations of vitamin D with inflammation but data in representative older adult studies is lacking. We aimed to investigate the association of C-reactive protein (CRP) with vitamin D status in a representative sample of the older Irish population. The concentrations of 25-hydroxyvitamin D (25(OH)D) and CRP was measured in 5,381 community… Continue reading Vitamin D status & associations with inflammation in older adults
Physical Activity Dose and Depression in a Cohort of Older Adults in The Irish Longitudinal Study on Ageing
Importance Among older adults (aged ≥50 years), depression is associated with an increased risk of physical, social, and cognitive dysfunction. Regular moderate to vigorous physical activity (MVPA) has been associated with lower odds of depression. However, the lowest dose for protection against depression and the extent to which exceeding this level conveys additional protection are unknown.Objective To… Continue reading Physical Activity Dose and Depression in a Cohort of Older Adults in The Irish Longitudinal Study on Ageing
Objectively Measured Visual Impairment and Dementia Prevalence in Older Adults in the US
Importance Estimates of the association between visual impairment (VI) and dementia in the US population are based on self-reported survey data or measures of visual function that are at least 15 years old. Older adults are at high risk of VI and dementia so there is a need for up-to-date national estimates based on objective assessments.Objective To… Continue reading Objectively Measured Visual Impairment and Dementia Prevalence in Older Adults in the US
Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia
Objective To test the hypothesis that higher level of cognitive activity predicts older age at dementia onset in Alzheimer disease (AD) dementia.Methods As part of a longitudinal cohort study, 1,903 older persons without dementia at enrollment reported their frequency of participation in cognitively stimulating activities. They had annual clinical evaluations to diagnose dementia and AD, and the… Continue reading Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia
The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
Highlights•This is the first study to investigate the mediation effect of GMV on the association between HbA1c and depression.•Hba1c was negatively associated with GMV, and that association were stronger in prediabetic participants.•Cerebral GMV plays a mediating role on the association “HbA1c-depression”, with a proportions of 6.82%.•Effective control of glycemia can potentially prevent brain abnormality and… Continue reading The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
Association of Preoperative High-Intensity Interval Training With Cardiorespiratory Fitness and Postoperative Outcomes Among Adults Undergoing Major SurgeryA Systematic Review and Meta-Analysis
Importance Preoperative high-intensity interval training (HIIT) is associated with improved cardiorespiratory fitness (CRF) and may improve surgical outcomes.Objective To summarize data from studies comparing the association of preoperative HIIT vs standard hospital care with preoperative CRF and postoperative outcomes.Data Sources Data sources included Medline, Embase, Cochrane Central Register of Controlled Trials Library, and Scopus databases with no language… Continue reading Association of Preoperative High-Intensity Interval Training With Cardiorespiratory Fitness and Postoperative Outcomes Among Adults Undergoing Major SurgeryA Systematic Review and Meta-Analysis
Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction
Highlights•Diet-induced NAFLD and associated systemic alterations result in behavioural changes and low-grade brain tissue hypoxia.•Brain hypoxia is likely linked to the induced low-grade brain inflammation, as well as cerebrovascular, glial, and metabolic alterations.•Mct1 haploinsufficient mice are protected from NAFLD and detrimental cerebral alterations.•MCT1 is a potential novel therapeutic target for preventing and/or treating NAFLD and the… Continue reading Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction
Elevated C-reactive protein mediates the liver-brain axis: a preliminary study
BackgroundChronic liver diseases of all etiologies exist along a spectrum with varying degrees of hepatic fibrosis. Despite accumulating evidence implying associations between liver fibrosis and cognitive functioning, there is limited research exploring the underlying neurobiological factors and the possible mediating role of inflammation on the liver-brain axis.MethodsUsing data from the UK Biobank, we examined the cross-sectional association… Continue reading Elevated C-reactive protein mediates the liver-brain axis: a preliminary study
Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes
The additional therapeutic effects of regular exercise during a dietary weight loss program in people with obesity and prediabetes are unclear. Here, we show that whole-body (primarily muscle) insulin sensitivity (primary outcome) was 2-fold greater (P = 0.006) after 10% weight loss induced by calorie restriction plus exercise training (Diet+EX; n = 8, 6 women) than 10% weight loss induced… Continue reading Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes
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