Highlights•Aspartame increases insulin levels through parasympathetic activation•An insulin-dependent mechanism of the aspartame-aggravated atherosclerosis•The CX3CL1-CX3CR1 signaling mediates insulin-induced endothelial inflammation•A CX3CL1-CX3CR1-dependent mechanism of aspartame-exacerbated atherosclerosis SummaryConsumption of artificial sweeteners (ASWs) in various foods and beverages has been linked to an increased risk of cardiovascular diseases (CVDs). However, molecular mechanisms underlying ASW-associated CVD remain unknown. Here, we… Continue reading #Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Long-term survival and durable recovery of #heart failure in patients with triglyceride deposit #cardiomyovasculopathy treated with tricaprin
Heart disease is a major global threat. Triglyceride deposit cardiomyovasculopathy (TGCV) is an emerging, noncommunicable, adult-onset heart disease, first identified in Japanese patients with heart failure (HF) requiring cardiac transplantation1,2,3. In TGCV, defective intracellular lipolysis of long-chain triglycerides (TGs) results in cellular steatosis and energy failure mainly in cardiomyocytes4 and smooth muscle cells5, leading to… Continue reading Long-term survival and durable recovery of #heart failure in patients with triglyceride deposit #cardiomyovasculopathy treated with tricaprin
The Spiral of #Attention, Arousal, and Release: A Comparative Phenomenology of Jhāna Meditation and Speaking in Tongues
Buddhist Jhāna meditation and the Christian practice of speaking in tongues appear wildly distinct. These spiritual techniques differ in their ethical, theological, and historical frames and seem, from the outside, to produce markedly different states of consciousness-one a state of utter calm and the other of high emotional arousal. Yet, our phenomenological interviews with experienced… Continue reading The Spiral of #Attention, Arousal, and Release: A Comparative Phenomenology of Jhāna Meditation and Speaking in Tongues
Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial
Sodium–glucose co-transporter (SGLT)-2 inhibitors have shown consistent benefit in improving heart failure-related outcomes but not ischaemic cardiovascular events such as myocardial infarction or stroke. We assessed if the dual SGLT1/2 inhibitor sotagliflozin improves ischaemic outcomes.MethodsWe did a prespecified secondary analysis of the SCORED trial, which was a double-blind, placebo-controlled, randomised clinical trial enrolling patients (aged… Continue reading Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial
#Cognitive Decline After First-Time Transient #Ischemic Attack
Question When controlling for vascular and demographic factors, does transient ischemic attack confer an independent risk for cognitive decline?Findings In this longitudinal cohort study (Reasons for Geographic and Racial Differences in Stroke [REGARDS]), pre-event and postevent cognitive trajectories were compared in 356 individuals with TIA, 965 individuals with stroke, and 14 882 asymptomatic controls. A single,… Continue reading #Cognitive Decline After First-Time Transient #Ischemic Attack
#Egg Consumption: Trends Over 48 Years, Patterns Across the Lifespan, and Predictors of Intake
Background/Objectives: Eggs are an excellent nutritional source. However, historical associations of dietary cholesterol with serum cholesterol and cardiovascular disease, along with restrictive dietary guidelines may have been barriers to egg consumption. This study examines trends over time, patterns, and predictors of egg consumption in individuals followed for 48 years, and current barriers to usage. Methods:… Continue reading #Egg Consumption: Trends Over 48 Years, Patterns Across the Lifespan, and Predictors of Intake
Long-term #yogurt intake and colorectal #cancer incidence subclassified by Bifidobacterium abundance in tumor
Evidence suggests a tumor-suppressive effect of the intake of yogurt, which typically contains Bifidobacterium. We hypothesized that long-term yogurt intake might be associated with colorectal cancer incidence differentially by tumor subgroups according to the amount of tissue Bifidobacterium. We utilized the prospective cohort incident-tumor biobank method and resources of two prospective cohort studies. Inverse probability… Continue reading Long-term #yogurt intake and colorectal #cancer incidence subclassified by Bifidobacterium abundance in tumor
Microbial metabolites tune #amygdala neuronal hyperexcitability and #anxiety-linked behaviors
Changes in gut microbiota composition have been linked to anxiety behavior in rodents. However, the underlying neural circuitry linking microbiota and their metabolites to anxiety behavior remains unknown. Using male C57BL/6J germ-free (GF) mice, not exposed to live microbes, increased anxiety-related behavior was observed correlating with a significant increase in the immediate early c-Fos gene… Continue reading Microbial metabolites tune #amygdala neuronal hyperexcitability and #anxiety-linked behaviors
Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Question Does the use of a reduced-sodium, added-potassium salt substitute vs regular salt decrease the risk of stroke recurrence and death in patients with a history of stroke?Findings In this prespecified subgroup analysis of the Salt Substitute and Stroke Study (SSaSS) trial involving 15 249 patients with stroke, the use of a salt substitute led… Continue reading Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
2 Medical News 