Low serum albumin levels resulting from inflammation-induced capillary leakage or disease-related anorexia during acute illness are associated with poor outcomes. We investigated the relationship of nutritional status and inflammation with low serum albumin levels and 30-day mortality in a large cohort.. Among the 2465 patients, 1019 (41%) had low serum albumin levels (<34 g/L), 619… Continue reading Relationship of #Nutritional Status, #Inflammation, and Serum #Albumin Levels During Acute Illness: A Prospective Study
Homologous recombination within the spike glycoprotein of the newly identified #coronavirus may boost cross‐species transmission from snake to human
The current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel coronavirus designated 2019‐nCoV by the World Health Organization, as determined by sequencing the viral RNA genome. Many patients were potentially exposed to wildlife animals at the Huanan seafood wholesale market, where poultry, snake, bats, and other farm animals… Continue reading Homologous recombination within the spike glycoprotein of the newly identified #coronavirus may boost cross‐species transmission from snake to human
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Recent discoveries have implicated the gut #microbiome in the progression and severity of #Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in… Continue reading Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Effects of physical activity #calorie equivalent food labelling to reduce food selection and consumption: systematic review and meta-analysis of randomised controlled studies
There is limited evidence that nutritional labelling on food/drinks is changing eating behaviours. Physical activity calorie equivalent (PACE) food labelling aims to provide the public with information about the amount of physical activity required to expend the number of kilocalories in food/drinks (eg, calories in this pizza requires 45 min of running to burn), to encourage… Continue reading Effects of physical activity #calorie equivalent food labelling to reduce food selection and consumption: systematic review and meta-analysis of randomised controlled studies
Sex Differences in Blood #Pressure Trajectories Over the Life Course
..Women compared with men exhibited a steeper increase in BP that began as early as in the third decade and continued through the life course (likelihood ratio test χ2 = 531 for systolic BP; χ2 = 123 for diastolic BP; χ2 = 325 for MAP; and χ2 = 572 for PP; P for all <.001). After adjustment for multiple cardiovascular disease risk factors,… Continue reading Sex Differences in Blood #Pressure Trajectories Over the Life Course
Association of #bisphosphonate therapy with incident lower extremity #fractures in persons with spinal cord injuries/disorders
To investigate the association between prescriptions for bisphosphonates, calcium/Vitamin D supplements, and receipt of DXA screening, and incident fracture risk in men and women with a spinal cord injury/disorder (SCI/D).. There was no significant association between prescriptions for bisphosphonates and incident lower extremity fractures in men (OR 1.04, 95% CI: 0.62-1.77) or women (OR 1.02,… Continue reading Association of #bisphosphonate therapy with incident lower extremity #fractures in persons with spinal cord injuries/disorders
Effect of #Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients
To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions.. Geometric mean maximum plasma concentrations of all 6 active ingredients were greater than 0.5 ng/mL, and this threshold was surpassed on day 1 after a single application… Continue reading Effect of #Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients
Prevention of #tuberculosis in macaques after intravenous BCG immunization
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide. The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission. Here we show that intravenous administration of BCG profoundly alters the protective outcome of Mtb challenge in non-human… Continue reading Prevention of #tuberculosis in macaques after intravenous BCG immunization
Sex Steroid #Hormones and #Asthma in a Nationwide Study of U.S. Adults
Women have a higher burden of asthma than men. Although sex hormones may explain sex differences in asthma, their role is unclear.. ..Free testosterone levels in the fourth quartile were associated with lower odds of current asthma in women (odds ratio [OR] for the fourth quartile [Q4] vs. Q1, 0.56; 95% confidence interval [CI], 0.39–0.80).… Continue reading Sex Steroid #Hormones and #Asthma in a Nationwide Study of U.S. Adults
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