The rapid shifts in society have altered human behavioural patterns, with increased evening activities, increased screen time and changed sleep schedules. As an explicit manifestation of circadian rhythms, chronotype is closely intertwined with physical and mental health. Night owls often exhibit unhealthier lifestyle habits, are more susceptible to mood disorders and have poorer physical fitness… Continue reading Multimodal population study reveals the neurobiological underpinnings of #chronotype
Deaths “due to” #COVID-19 and deaths “with” COVID-19 during the #Omicron variant surge, among hospitalized patients in seven tertiary-care hospitals, Athens, Greece
In Greek hospitals, all deaths with a positive SARS-CoV-2 test are counted as COVID-19 deaths. Our aim was to investigate whether COVID-19 was the primary cause of death, a contributing cause of death or not-related to death amongst patients who died in hospitals during the Omicron surge and were registered as COVID-19 deaths. Additionally, we… Continue reading Deaths “due to” #COVID-19 and deaths “with” COVID-19 during the #Omicron variant surge, among hospitalized patients in seven tertiary-care hospitals, Athens, Greece
Dose Response of Incidental Physical #Activity Against #Cardiovascular Events and Mortality
Few middle-aged and older adults engage in regular leisure-time exercise. Incidental physical activity (IPA) encompasses activities of daily living outside the leisure-time domain. No dose-response study is available to guide IPA-focused interventions and guidelines. We examined the associations of device-assessed IPA intensities (vigorous [VIPA], moderate [MIPA], light [LIPA]) with major adverse cardiovascular events (MACE) and… Continue reading Dose Response of Incidental Physical #Activity Against #Cardiovascular Events and Mortality
Repeated #COVID-19 #Vaccination as a Poor Prognostic Factor in Pancreatic #Cancer: A Retrospective, Single-Center Cohort Study
AbstractThe COVID-19 vaccine is a significant technological advancement with widespread global use. However, its effect on cancer immunity, particularly with repeated vac-cinations, remains unclear. We aimed to investigate the relationship between repeated vaccinations and pancreatic cancer (PC) prognosis. Additionally, we examined serum IgG4 levels, known to be an immune suppressor and increased with repeated vac-cinations.… Continue reading Repeated #COVID-19 #Vaccination as a Poor Prognostic Factor in Pancreatic #Cancer: A Retrospective, Single-Center Cohort Study
Systemic deficits in lipid homeostasis promote aging-associated impairments in #B cell progenitor development
Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fat deposition in the bone marrow, impaired hematopoietic stem and progenitor cell (HSPC) function, and a propensity towards myeloid differentiation. This shift in lineage bias can lead to pre-malignant… Continue reading Systemic deficits in lipid homeostasis promote aging-associated impairments in #B cell progenitor development
COVID-19 #vaccines and #adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals
AbstractBackground: The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Global Vaccine Data Network™ (GVDN®), facilitates comprehensive assessment of vaccine safety. This study aimed to evaluate the risk of adverse events of special interest (AESI) following COVID-19 vaccination from 10 sites across eight countries.Methods: Using a common protocol, this observational cohort… Continue reading COVID-19 #vaccines and #adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals
Healthy #sleep patterns and risk of hospitalization for #infection: a large community-based cohort study
Sleep behaviours are potentially modifiable risk factors for infectious disease. However, little is known about the combined effects of multiple sleep factors on the risk of infections. We investigated the prospective associations of combined healthy sleep patterns with the risk of hospitalization for infection in 397,523 participants (mean (SD) age: 56.3 (8.1) years) from the… Continue reading Healthy #sleep patterns and risk of hospitalization for #infection: a large community-based cohort study
60 is the new 40: preparing for better bone #health in later life
Objective: In this study we evaluated associations between nutritional factors, including calcium supplementation, and outcomes of fracture and cardiovascular mortality. We chose to report both outcomes as an illustration of the importance of nutritional factors in midlife to heart disease as this may be more impactful for supporting behavior change strategies, particularly in men.Methods: This… Continue reading 60 is the new 40: preparing for better bone #health in later life
Association Between #Alcohol Consumption, #Cognitive Abilities, and Neuropathologic Changes
Background and ObjectivesHeavy alcohol consumption is a major global health concern linked to increased morbidity and mortality. However, the long-term impact of excessive alcohol consumption on cognitive abilities and dementia-related neuropathology is unclear. The aim of this study was to analyze the association between alcohol consumption and age-related neuropathologic outcomes in a population-based autopsy study.MethodsThis… Continue reading Association Between #Alcohol Consumption, #Cognitive Abilities, and Neuropathologic Changes
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