BackgroundMortality statistics are fundamental to public health decision making. Mortality varies by time and location, and its measurement is affected by well known biases that have been exacerbated during the COVID-19 pandemic. This paper aims to estimate excess mortality from the COVID-19 pandemic in 191 countries and territories, and 252 subnational units for selected countries,… Continue reading Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21
Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes
Aims/IntroductionWe aimed to study the predictive ability of visit-to-visit variability in albuminuria for changes in renal function in patients with type 2 diabetes mellitus. Materials and MethodsThe cohort study was carried out in a single medical center. In the model development cohort of 1008 subjects, we developed the albuminuria variability score (AVS) to evaluate the visit-to-visit… Continue reading Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes
The immunoregulatory landscape of human tuberculosis granulomas
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought to affect disease outcome. However, our understanding of the spatial relationships that control human granulomas is limited. Here, we used multiplexed ion beam imaging by time of flight (MIBI-TOF) to image 37 proteins… Continue reading The immunoregulatory landscape of human tuberculosis granulomas
Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism
The mediobasal hypothalamus (MBH) is the central region in the physiological response to metabolic stress. The FK506-binding protein 51 (FKBP51) is a major modulator of the stress response and has recently emerged as a scaffolder regulating metabolic and autophagy pathways. However, the detailed protein-protein interactions linking FKBP51 to autophagy upon metabolic challenges remain elusive. We… Continue reading Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
In the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has driven investigational studies and controlled clinical trials on antiviral treatments and vaccines that have undergone regulatory approval. Now that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants may become endemic over time, there remains a need to identify drugs that… Continue reading A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity
Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 in adult mice depressed physical performance. Muscle microvascular endothelial cell apoptosis and capillary rarefaction were evident and sufficient to account for the… Continue reading Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity
The effects of music & auditory beat stimulation on anxiety: A randomized clinical trial
Background and objectivesMusic and auditory beat stimulation (ABS) in the theta frequency range (4–7 Hz) are sound-based anxiety treatments that have been independently investigated in prior studies. Here, the anxiety-reducing potential of calm music combined with theta ABS was examined in a large sample of participants. MethodsAn open-label randomized controlled trial was conducted with participants… Continue reading The effects of music & auditory beat stimulation on anxiety: A randomized clinical trial
Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
BackgroundOral microbiota are thought to influence blood pressure (BP) regulation. However, epidemiological data supporting this hypothesis are limited. We examined associations between oral microbiota, BP, and incident hypertension in postmenopausal women. Methods and ResultsBaseline (1997–2001) examinations were completed on 1215 women (mean age, 63 years) during which subgingival plaque was collected, BP was measured, and… Continue reading Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant
BACKGROUNDA rapid increase in coronavirus disease 2019 (Covid-19) cases due to the omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 in highly vaccinated populations has aroused concerns about the effectiveness of current vaccines. METHODSWe used a test-negative case–control design to estimate vaccine effectiveness against symptomatic disease caused by the omicron and delta (B.1.617.2)… Continue reading Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant
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