A key research program within the meaning in life (MIL) literature aims to identify the key contributors to MIL. The experience of existential mattering, purpose in life and a sense of coherence are currently posited as three primary contributors to MIL. However, it is unclear whether they encompass all information people consider when judging MIL.… Continue reading Experiential appreciation as a pathway to meaning in life
Update: COVID-19 Vaccine Candidates and Abortion-Derived Cell Lines
Accurate information about the development and production of COVID-19 vaccines is essential, especially because many proposed candidates use newer molecular technologies for production of a viral vaccine. One concern regarding the ethical assessment of viral vaccine candidates is the potential use of abortion-derived cell lines in the development, production or testing of a vaccine. This… Continue reading Update: COVID-19 Vaccine Candidates and Abortion-Derived Cell Lines
Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series
Objective To characterise the clinical features of monkeypox infection in humans.Design Descriptive case series.Setting A regional high consequences infectious disease centre with associated primary and secondary care referrals, and affiliated sexual health centres in south London between May and July 2022.Participants 197 patients with polymerase chain reaction confirmed monkeypox infection.Results The median age of participants… Continue reading Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series
Low Daily Step Count Is Associated With a High Risk of Hospital Admission and Death in Community-Dwelling Patients With Cirrhosis
Background & AimsDaily step count measures cardiorespiratory fitness and has been associated with clinical outcomes. However, its utility in patients with cirrhosis remains largely unexplored. We aimed to investigate the association between step count, frailty metrics, and clinical outcomes in cirrhosis.MethodsAll participants underwent frailty evaluation with the liver frailty index, 6-minute walk test, and gait… Continue reading Low Daily Step Count Is Associated With a High Risk of Hospital Admission and Death in Community-Dwelling Patients With Cirrhosis
Risk of fractures and subsequent mortality in alcohol-related cirrhosis: A nationwide population-based cohort study
Background and aimsAlcohol-related cirrhosis is linked to increased risk of fractures, but this has seldom been quantified nationally or compared against non-cirrhotic controls. Here, we determined the rate and risk of fractures and post-fracture mortality in patients with alcohol-related cirrhosis compared to individuals from the general population.MethodsIn this nationwide population-based cohort study, data were retrieved… Continue reading Risk of fractures and subsequent mortality in alcohol-related cirrhosis: A nationwide population-based cohort study
Clinical efficacy and safety of linezolid in intensive care unit patients
AbstractBackgroundTo characterize the population of critically ill patients and infections treated with linezolid in the intensive care unit (ICU), and to evaluate the clinical efficacy and safety of linezolid therapy.MethodsThis multi-center, observational, real-world study was conducted across 52 hospitals between June 9, 2018, and December 28, 2019. Patients who met the following inclusion criteria were… Continue reading Clinical efficacy and safety of linezolid in intensive care unit patients
Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial
Mindfulness-based interventions are widely used to target pain, yet their neural mechanisms of action are insufficiently understood. The authors studied neural and subjective pain response in a randomized active-control trial of mindfulness-based stress reduction (MBSR) alongside long-term meditation practitioners.Methods:Healthy participants (N=115) underwent functional neuroimaging during a thermal acute pain task before and after random assignment… Continue reading Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial
BLOGSITE UPDATE
Since today and until August 31th, there will be just One daily update to the blogsite. Frohe Feiertage Euch Allen!
Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination
COVID-19 mRNA vaccines effectively reduce incidence of severe disease, hospitalisation and death. The biodistribution and pharmacokinetics of the mRNA-containing lipid nanoparticles (LNPs) in these vaccines are unknown in humans. In this study, we used qPCR to track circulating mRNA in blood at different time-points after BNT162b2 vaccination in a small cohort of healthy individuals. We… Continue reading Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination
2 Medical News 