The high overlapping nature of various features across multiple mental health disorders suggests the existence of common psychopathology factor(s) (p-factors) that mediate similar phenotypic presentations across distinct but relatable disorders. In this perspective, we argue that circadian rhythm disruption (CRD) is a common underlying p-factor that bridges across mental health disorders within their age and… Continue reading The hidden link between circadian entropy and mental health disorders
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment can be obtained with a brief pulse of the drug in early adulthood in female Drosophila and mice. In Drosophila, a brief, early rapamycin treatment… Continue reading Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
Environmental impassivity: Blunted emotionality undermines concern for the environment
The average American believes in climate change, worries about it, and supports related policy, but there are still considerable differences—across individuals and with political ideology—that limit the ability to foster change. Researchers and practitioners often increase concern and action for others through feelings of empathy, which also increases pro-environmentalism. However, some people appear less emotionally… Continue reading Environmental impassivity: Blunted emotionality undermines concern for the environment
I share, therefore I know? Sharing online content – even without reading it – inflates subjective knowledge
Billions of people across the globe use social media to acquire and share information. A large and growing body of research examines how consuming online content affects what people know. The present research investigates a complementary, yet previously unstudied question: how might sharing online content affect what people think they know? Sharing signals expertise, and people frequently… Continue reading I share, therefore I know? Sharing online content – even without reading it – inflates subjective knowledge
Predicting the efficacy of variant-modified COVID-19 vaccine boosters
As a result of the emergence and circulation of antigenically distinct SARS-CoV-2 variants, a number of variant-modified COVID-19 vaccines have been developed. Here we perform a meta-analysis of the available data on neutralisation titres from clinical studies comparing booster vaccination with either the current ancestral-based vaccines or variant-modified vaccines. We then use this to predict… Continue reading Predicting the efficacy of variant-modified COVID-19 vaccine boosters
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
BackgroundStatin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin… Continue reading Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Persistent varicella zoster virus infection following mRNA COVID-19 vaccination was associated with the presence of encoded spike protein in the lesion
BackgroundSince the campaign of vaccination against COVID-19 was started, a wide variety of cutaneous adverse effects after vaccination has been documented worldwide. Varicella zoster virus (VZV) reactivation was reportedly the most frequent cutaneous reaction in men after administration of mRNA COVID-19 vaccines, especially BNT162b2.AimsA patient, who had persistent skin lesions after BNT162b2 vaccination for such… Continue reading Persistent varicella zoster virus infection following mRNA COVID-19 vaccination was associated with the presence of encoded spike protein in the lesion
Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma
Activating KRAS mutations and functional loss of members of the SWI/SNF complex, including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC). How these mutations cooperate to promote CC has not been established. Using murine models of hepatocyte and biliary-specific lineage tracing, we show that Kras and Arid1a mutations drive the formation of CC and tumor precursors from the biliary compartment,… Continue reading Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma
Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke
Background and Objectives: Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early onset ischemic stroke.Methods: We performed a meta-analysis of genome-wide association studies of early onset stroke (EOS), ages 18-59, using individual level… Continue reading Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke
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