Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of diagnostic assays. Quantification of α-synuclein aggregates in body fluids is challenging, and requires highly sensitive and specific assays. Recent studies suggest that α-synuclein aggregates may be shed into stool. We used… Continue reading Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
Air pollution and decreased bone mineral density among Women’s Health Initiative participants
BackgroundOsteoporosis heavily affects postmenopausal women and is influenced by environmental exposures. Determining the impact of criteria air pollutants and their mixtures on bone mineral density (BMD) in postmenopausal women is an urgent priority.MethodsWe conducted a prospective observational study using data from the ethnically diverse Women's Health Initiative Study (WHI) (enrollment, September 1994–December 1998; data analysis,… Continue reading Air pollution and decreased bone mineral density among Women’s Health Initiative participants
Associations between types and sources of dietary carbohydrates and cardiovascular disease risk: a prospective cohort study of UK Biobank participants
Recent studies have reported that the associations between dietary carbohydrates and cardiovascular disease (CVD) may depend on the quality, rather than the quantity, of carbohydrates consumed. This study aimed to assess the associations between types and sources of dietary carbohydrates and CVD incidence. A secondary aim was to examine the associations of carbohydrate intakes with… Continue reading Associations between types and sources of dietary carbohydrates and cardiovascular disease risk: a prospective cohort study of UK Biobank participants
Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination: A case report
A 71-year-old man was transferred urgently to our hospital after collapsing near his home post the first shot of the BNT162b2 coronavirus disease 2019 vaccine (Pfizer-BioNTech, Comirnaty®). Immediately after arrival at our hospital, cardiac arrest due to complete atrioventricular block with no ventricular escaped beats was observed on electrocardiogram. Echocardiography showed preserved left ventricular ejection… Continue reading Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination: A case report
Effect of Technology-Enhanced Screening in Addition to Standard Targeted Clinician Education on the Duration of Untreated PsychosisA Cluster Randomized Clinical Trial
Reducing the duration of untreated psychosis (DUP) is essential to improving outcomes for people with first-episode psychosis (FEP). Current US approaches are insufficient to reduce DUP to international standards of less than 90 days.Objective To determine whether population-based electronic screening in addition to standard targeted clinician education increases early detection of psychosis and decreases DUP,… Continue reading Effect of Technology-Enhanced Screening in Addition to Standard Targeted Clinician Education on the Duration of Untreated PsychosisA Cluster Randomized Clinical Trial
Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke
Background and objectives: Previous studies have reported the protective effect of pioglitazone on dementia in type 2 diabetic mellitus (DM) patients. Recent studies have shown that pioglitazone also lowers the risk of primary and recurrent stroke. Understanding the characteristics of patients particularly associated with the benefits of pioglitazone would facilitate its personalized use by specifying… Continue reading Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke
Healthy Eating Patterns and Risk of Total and Cause-Specific Mortality
The current Dietary Guidelines for Americans recommend multiple healthy eating patterns. However, few studies have examined the associations of adherence to different dietary patterns with long-term risk of total and cause-specific mortality.Objective To examine the associations of dietary scores for 4 healthy eating patterns with risk of total and cause-specific mortality.Design, Setting, and Participants This… Continue reading Healthy Eating Patterns and Risk of Total and Cause-Specific Mortality
Endovascular Therapy for Acute Stroke with a Large Ischemic Region
Endovascular therapy for acute ischemic stroke is generally avoided when the infarction is large, but the effect of endovascular therapy with medical care as compared with medical care alone for large strokes has not been well studied. We conducted a multicenter, open-label, randomized clinical trial in Japan involving patients with occlusion of large cerebral vessels… Continue reading Endovascular Therapy for Acute Stroke with a Large Ischemic Region
Phthalates and Incident Diabetes in Midlife Women: The Study of Women’s Health Across the Nation (SWAN)
ContextPhthalates are hypothesized to contribute to diabetes, but longitudinal evidence in humans is limited.ObjectiveWe examined whether phthalate exposure was associated with a higher incidence of diabetes in a racially/ethnically diverse cohort of midlife women.MethodsIn the Study of Women's Health Across the Nation Multipollutant Study, we followed 1308 women without diabetes in 1999-2000 for 6 years.… Continue reading Phthalates and Incident Diabetes in Midlife Women: The Study of Women’s Health Across the Nation (SWAN)
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