IntroductionExergame-based training is emerging as the most effective exercise modality for improving cognition, yet its neural correlates remain largely unexplored. This study explored gray matter (GM) and white matter (WM) changes following the addition of ‘Brain-IT’ training to usual care in mild neurocognitive disorder (mNCD) and their associations with cognitive performance changes.MethodsWe included 41 participants… Continue reading Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
Category: Tech
Digital #Eye #Strain Monitoring for One-Hour #Smartphone Engagement Through Eye Activity Measurement System
Smartphones have revolutionized our daily lives, becoming portable pocket computers with easy internet access. India, the second-highest smartphone and internet user, experienced a significant rise in smartphone usage between 2013 and 2024. Prolonged smartphone use, exceeding 20 min at a time, can lead to physical and mental health issues, including psychophysiological disorders. Digital devices and… Continue reading Digital #Eye #Strain Monitoring for One-Hour #Smartphone Engagement Through Eye Activity Measurement System
Phenome-wide Analysis of #Diseases in Relation to Objectively Measured #Sleep Traits and Comparison with Subjective Sleep Traits in 88,461 Adults
Background: Sleep traits have been suggested to correlate with various diseases, but most evidence is based on subjective sleep measurement. We investigated the associations of accelerometer-derived objective sleep traits with diseases throughout physiological systems to ascertain whether the disease spectrum related to objective sleep traits differs from that related to subjective sleep traits. Methods: In… Continue reading Phenome-wide Analysis of #Diseases in Relation to Objectively Measured #Sleep Traits and Comparison with Subjective Sleep Traits in 88,461 Adults
Controlled colonization of the human #gut with a genetically engineered microbial therapeutic
Editor’s summaryThe gut #microbiota has long been an aspirational target for clinical delivery of therapeutics. Successful therapy by this route depends on ensuring engraftment of the therapeutic organisms and their clearance after treatment. Whitaker et al. have engineered a strain of Bacteroides vulgatus, which is commonly found in the gut of healthy humans, with two… Continue reading Controlled colonization of the human #gut with a genetically engineered microbial therapeutic
#AI -guided patient stratification improves outcomes and efficiency in the AMARANTH #Alzheimer’s Disease clinical trial
Alzheimer’s Disease (AD) drug discovery has been hampered by patient heterogeneity, and the lack of sensitive tools for precise stratification. Here, we demonstrate that our robust and interpretable AI-guided tool (predictive prognostic model, PPM) enhances precision in patient stratification, improving outcomes and decreasing sample size for a AD clinical trial. The AMARANTH trial of lanabecestat,… Continue reading #AI -guided patient stratification improves outcomes and efficiency in the AMARANTH #Alzheimer’s Disease clinical trial
#Thimerosal as a #Vaccine #Preservative
DunedinPACNI estimates the longitudinal Pace of #Aging from a single brain #image to track health and disease
To understand how aging affects functional decline and increases disease risk, it is necessary to develop measures of how fast a person is aging. Using data from the Dunedin Study, we introduce an accurate and reliable measure for the rate of longitudinal aging derived from cross-sectional brain magnetic resonance imaging, that is, the Dunedin Pace… Continue reading DunedinPACNI estimates the longitudinal Pace of #Aging from a single brain #image to track health and disease
Preventing #pressure #ulcers by increasing pressure: An unorthodox alternating-pressure mattress
Despite the devastating effects of pressure ulcers (PUs), little is understood about how they can be prevented using alternating-pressure (AP) mattresses. Such mattresses typically aim to minimize the pressures imparted while alternating between different states of pressure to prevent areas of tissue from being persistently occluded of blood flow. In this work, we built an… Continue reading Preventing #pressure #ulcers by increasing pressure: An unorthodox alternating-pressure mattress
Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of #cardiac #ageing
Extracellular matrix remodelling of cardiac tissue is a key contributor to age-related cardiovascular disease and dysfunction. Such remodelling is multifaceted including changes to the biochemical composition, architecture and mechanics, clouding our understanding of how and which extracellular matrix properties contribute to a dysfunctional state. Here we describe a decellularized extracellular matrix–synthetic hydrogel hybrid scaffold that… Continue reading Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of #cardiac #ageing
