Prospective Associations of Different Combinations of #Aerobic and #Muscle-Strengthening Activity With All-Cause, #Cardiovascular, and Cancer Mortality

Studies examining the associations of different combinations of intensity-specific aerobic and muscle strengthening activity (MSA) with all-cause and cause-specific mortality are scarce; the few available estimates are disparate.Objective  To examine the prospective associations of different combinations of moderate aerobic physical activity (MPA), vigorous aerobic physical activity (VPA), and MSA with all-cause, cardiovascular (CVD), and cancer mortality.Design,… Continue reading Prospective Associations of Different Combinations of #Aerobic and #Muscle-Strengthening Activity With All-Cause, #Cardiovascular, and Cancer Mortality

#Exercise training and resting blood #pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials 

Objective To perform a large-scale pairwise and network meta-analysis on the effects of all relevant exercise training modes on resting blood pressure to establish optimal antihypertensive exercise prescription practices.Design Systematic review and network meta-analysis.Data sources PubMed (Medline), the Cochrane library and Web of Science were systematically searched.Eligibility criteria Randomised controlled trials published between 1990 and February 2023. All relevant… Continue reading #Exercise training and resting blood #pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials 

Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease

Guidelines recommend 150 minutes or more of moderate to vigorous physical activity (MVPA) per week for overall health benefit, but the relative effects of concentrated vs more evenly distributed activity are unclear.Objective  To examine associations between an accelerometer-derived “weekend warrior” pattern (ie, most MVPA achieved over 1-2 days) vs MVPA spread more evenly with risk of… Continue reading Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease

Physical Activity Dose and Depression in a Cohort of Older Adults in The Irish Longitudinal Study on Ageing

Importance  Among older adults (aged ≥50 years), depression is associated with an increased risk of physical, social, and cognitive dysfunction. Regular moderate to vigorous physical activity (MVPA) has been associated with lower odds of depression. However, the lowest dose for protection against depression and the extent to which exceeding this level conveys additional protection are unknown.Objective  To… Continue reading Physical Activity Dose and Depression in a Cohort of Older Adults in The Irish Longitudinal Study on Ageing

Association of Preoperative High-Intensity Interval Training With Cardiorespiratory Fitness and Postoperative Outcomes Among Adults Undergoing Major SurgeryA Systematic Review and Meta-Analysis

Importance  Preoperative high-intensity interval training (HIIT) is associated with improved cardiorespiratory fitness (CRF) and may improve surgical outcomes.Objective  To summarize data from studies comparing the association of preoperative HIIT vs standard hospital care with preoperative CRF and postoperative outcomes.Data Sources  Data sources included Medline, Embase, Cochrane Central Register of Controlled Trials Library, and Scopus databases with no language… Continue reading Association of Preoperative High-Intensity Interval Training With Cardiorespiratory Fitness and Postoperative Outcomes Among Adults Undergoing Major SurgeryA Systematic Review and Meta-Analysis

Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes

The additional therapeutic effects of regular exercise during a dietary weight loss program in people with obesity and prediabetes are unclear. Here, we show that whole-body (primarily muscle) insulin sensitivity (primary outcome) was 2-fold greater (P = 0.006) after 10% weight loss induced by calorie restriction plus exercise training (Diet+EX; n = 8, 6 women) than 10% weight loss induced… Continue reading Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes

Accelerometer-measured intensity-specific physical activity, genetic risk and incident type 2 diabetes: a prospective cohort study

Objective Although 30 min/day of moderate-intensity physical activity is suggested for preventing type 2 diabetes (T2D), the current recommendations exclusively rely on self-reports and rarely consider the genetic risk. We examined the prospective dose-response relationships between total/intensity-specific physical activity and incident T2D accounting for and stratified by different levels of genetic risk.Methods This prospective cohort study was… Continue reading Accelerometer-measured intensity-specific physical activity, genetic risk and incident type 2 diabetes: a prospective cohort study

Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in ChinaA Randomized Clinical Trial

Importance Type 2 diabetes (T2D) is associated with the progression of cognitive dysfunction. Physical activity benefits cognition, but no evidence from randomized clinical trials has shown whether tai chi chuan has better long-term benefits than fitness walking in cognitive function for patients with T2D and mild cognitive impairment (MCI).Objective To compare the effectiveness of tai… Continue reading Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in ChinaA Randomized Clinical Trial

Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users

BackgroundStatin use may exacerbate exercise-induced skeletal muscle injury caused by reduced coenzyme Q10 (CoQ10) levels, which are postulated to produce mitochondrial dysfunction.ObjectivesWe determined the effect of prolonged moderate-intensity exercise on markers of muscle injury in statin users with and without statin-associated muscle symptoms. We also examined the association between leukocyte CoQ10 levels and muscle markers,… Continue reading Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users