Physical inactivity is a recognized modifiable risk factor for Alzheimer’s disease (AD), yet its relationship with progression of AD pathology in humans remains unclear, limiting the effective translation into prevention trials. Using pedometer-measured step counts in cognitively unimpaired older adults, we demonstrated an association between higher physical activity and slower cognitive and functional decline in… Continue reading Physical #activity as a modifiable risk factor in preclinical #Alzheimer’s disease
Category: Sports
Association between frequency of meeting daily step thresholds and all-cause #mortality and #cardiovascular disease in older women
Objective To examine the associations between the number of days per week achieving various daily step thresholds and all-cause mortality and cardiovascular disease (CVD) incidence in older women.Methods We conducted a prospective cohort study of 13 547 women free of CVD and cancer (mean age 71.8 years). We included participants who wore an ActiGraph GT3X+ accelerometer for… Continue reading Association between frequency of meeting daily step thresholds and all-cause #mortality and #cardiovascular disease in older women
Comparative efficacy and safety of #exercise modalities in #knee #osteoarthritis: systematic review and network meta-analysis
Objective To assess the efficacy and safety of various exercise modalities as therapeutic interventions for managing knee osteoarthritis.Design Systematic review with network meta-analysis.Data sources PubMed, Embase, Cochrane Library, Web of Science, CINAHL, PsycINFO, AMED, PEDro, Scopus, ClinicalTrials.gov, ICTRP, and ClinicalTrialsRegister.eu from database inception to August 2024.Eligibility criteria for selecting studies Randomised controlled trials comparing different… Continue reading Comparative efficacy and safety of #exercise modalities in #knee #osteoarthritis: systematic review and network meta-analysis
Comparative efficacy of #Tai Chi versus #balance training on functional performance and #postural control during sit and stand transitions in individuals with #knee #osteoarthritis: A randomized trial
Objectives: This study evaluates the efficacy of Tai Chi versus balance training on functional performance and postural control during sit and stand transitions in individuals with knee osteoarthritis.Design: Single-blind randomized trial.Methods: Sixty-nine patients with knee osteoarthritis were assigned to Tai Chi (n = 35) or balance training (n = 34) for 12 weeks. Assessments were… Continue reading Comparative efficacy of #Tai Chi versus #balance training on functional performance and #postural control during sit and stand transitions in individuals with #knee #osteoarthritis: A randomized trial
Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
Objectives To evaluate the effects of brief bouts of exercise spread throughout the day, termed ‘exercise snacks’, on cardiorespiratory and muscular fitness, and cardiometabolic health outcomes in physically inactive adults and older adults (aged ≥65 years).Design Systematic review and meta-analysis.Data sources Seven databases were searched from inception to April 2025.Eligibility criteria Randomised controlled trials (RCTs)… Continue reading Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
To examine the dose-response associations of step count and stepping intensity with risk of cardiovascular mortality and incidence of heart failure (HF), myocardial infarction (MI), and stroke (major adverse cardiovascular events, MACE) in people with hypertension.Methods and resultsData were obtained from participants with established hypertension from the UK Biobank accelerometry sub-study. Participants wore a wrist-worn… Continue reading Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
Importance Moderate to vigorous–intensity physical activity (MVPA) is essential for primary and secondary prevention of cardiovascular disease (CVD), but long-term patterns around CVD events remain underexplored.Objective To evaluate MVPA trajectories across adulthood, pre-CVD and post-CVD changes, and demographic variations.Design, Setting, and Participants Data were drawn from CARDIA (Coronary Artery Risk Development in Young Adults), a… Continue reading Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
#Electrophysiological correlates of dynamic #cycling in #Parkinson’s diseaseAuthor
Physical exercise like dynamic cycling has shown promise in enhancing motor function in Parkinson’s disease (PD). We examined the underlying mechanisms of dynamic cycling in PD, emphasizing its impact on the activity of the subthalamic nucleus (STN), a pivotal region within the basal ganglia.MethodsThe investigation involved 100 dynamic cycling sessions conducted among nine PD individuals.… Continue reading #Electrophysiological correlates of dynamic #cycling in #Parkinson’s diseaseAuthor
Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
BackgroundDespite the rapid increase in evidence from the past decade on daily steps and health-related outcomes, existing systematic reviews primarily focused on few outcomes, such as all-cause mortality. This study synthesised the prospective dose-response relationship between daily steps and health outcomes including all-cause mortality, cardiovascular disease, cancer, type 2 diabetes, cognitive outcomes, mental health outcomes,… Continue reading Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
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