Urban residence has been highlighted as an environmental risk factor for schizophrenia and, to a lesser extent, several other psychiatric disorders. However, few studies have explored genetic effects on the choice of residence. Objective To investigate whether individuals with genetic predisposition to a range of psychiatric disorders have an increased likelihood to live in urban… Continue reading Association Between Genetic Risk for #Psychiatric Disorders and the Probability of Living in #Urban Settings
Category: Psychiatry
Association of accelerometer-derived #sleep measures with lifetime #psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank
Sleep problems are both symptoms of and modifiable risk factors for many psychiatric disorders. Wrist-worn accelerometers enable objective measurement of sleep at scale. Here, we aimed to examine the association of accelerometer-derived sleep measures with psychiatric diagnoses and polygenic risk scores in a large community-based cohort. Methods and findingsIn this post hoc cross-sectional analysis of… Continue reading Association of accelerometer-derived #sleep measures with lifetime #psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank
Total #sleep deprivation reduces top-down regulation of #emotion without altering bottom-up affective processing
Sleep loss is reported to influence affective processing, causing changes in overall mood and altering emotion regulation. These aspects of affective processing are seldom investigated together, making it difficult to determine whether total sleep deprivation has a global effect on how affective stimuli and emotions are processed, or whether specific components of affective processing are… Continue reading Total #sleep deprivation reduces top-down regulation of #emotion without altering bottom-up affective processing
Adjunctive #dietary intervention for #bipolar disorder: a randomized, controlled, parallel-group, modified double-blinded trial of a high n-3 plus low n-6 diet
To investigate the preliminary efficacy of a high n-3 plus low n-6 (H3-L6) dietary intervention in improving mood stability in Bipolar Disorder (BD) when compared to dietary intervention with usual U.S. levels of n-6 and n-3 polyunsaturated fatty acid (PUFA) intakes (control diet, CD). MethodsThis 2-arm, parallel-group, randomized, modified double-blind, controlled 48-week study of 12-week… Continue reading Adjunctive #dietary intervention for #bipolar disorder: a randomized, controlled, parallel-group, modified double-blinded trial of a high n-3 plus low n-6 diet
A “Proof of Concept” Randomized Controlled Trial of a Video Game Requiring Emotional Regulation to Augment #Anger Control Training
Emotional dysregulation leading to clinically significant anger and aggression is a common and substantial concern for youth and their families. While psychotropic medications and cognitive behavioral therapies can be effective, these modalities suffer from drawbacks such as significant side effects, high rates of attrition, and lack of real-world skill translation. Regulate and Gain Emotional Control… Continue reading A “Proof of Concept” Randomized Controlled Trial of a Video Game Requiring Emotional Regulation to Augment #Anger Control Training
#Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline
Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited. Objective: To impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and… Continue reading #Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline
Cross-sectional associations of schoolchildren’s #fruit and #vegetable consumption, and meal choices, with their mental well-being: a cross-sectional study
Poor mental well-being is a major issue for young people and is likely to have long-term negative consequences. The contribution of nutrition is underexplored. We, therefore, investigated the association between dietary choices and mental well-being among schoolchildren. Methods Data from 7570 secondary school and 1253 primary school children in the Norfolk Children and Young People… Continue reading Cross-sectional associations of schoolchildren’s #fruit and #vegetable consumption, and meal choices, with their mental well-being: a cross-sectional study
Incident Major #Depressive Disorder Predicted by Three Measures of Insulin #Resistance: A Dutch Cohort Study
Major depressive disorder is the leading cause of disability worldwide. Yet, there remain significant challenges in predicting new cases of major depression and devising strategies to prevent the disorder. An important first step in this process is identifying risk factors for the incidence of major depression. There is accumulating biological evidence linking insulin resistance, another… Continue reading Incident Major #Depressive Disorder Predicted by Three Measures of Insulin #Resistance: A Dutch Cohort Study
Altered Composition of Gut #Microbiota in #Depression: A Systematic Review
Cumulative evidence shows a linkage between gut microbiota pattern and depression through the brain-gut microbiome axis. The aim of this systematic review was to identify the alterations of the gut microbiota patterns in people with depression compared to healthy controls. A comprehensive literature search of human studies, published between January 2000 and June 2019, was… Continue reading Altered Composition of Gut #Microbiota in #Depression: A Systematic Review
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