Osteoarthritis is a common condition, but curative therapies are limited. Here, Liu and colleagues developed a biodegradable scaffold using PLLA [poly(L-lactic acid)] nanofibers that when placed under applied force generated a piezoelectric charge, leading to improved chondrogenesis in vitro. Rabbits with osteochondral defects in the medial femoral condyle that were treated with the PLLA scaffold… Continue reading Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits
Category: Orthopedy
Are biomechanics during gait associated with the structural disease onset and progression of lower limb osteoarthritis? A systematic review and meta-analysis
To evaluate if gait biomechanics are associated with increased risk of structurally diagnosed disease onset or progression of lower limb osteoarthritis (OA). MethodA systematic review of Medline and Embase was conducted from inception to July 2021. Two reviewers independently screened records, extracted data and assessed risk of bias. Included studies reported gait biomechanics at baseline,… Continue reading Are biomechanics during gait associated with the structural disease onset and progression of lower limb osteoarthritis? A systematic review and meta-analysis
Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis
Scalable knee osteoarthritis programs are needed to deliver recommended education, exercise, and weight loss interventions. Objective:To evaluate two 6-month, telehealth-delivered exercise programs, 1 with and 1 without dietary intervention. Design:3-group, parallel randomized (5:5:2) trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000930280) Setting:Australian private health insurance members. Participants:415 persons with symptomatic knee osteoarthritis and a body… Continue reading Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis
Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
To investigate whether osteoarthritis (OA)–specific assessment values (i.e. Western Ontario and McMaster University Osteoarthritis Index [WOMAC]) and generic pain and function (visual analog scale [VAS], Hanover Functionality Status Questionnaire [FFbH]) measured before and 12 months after arthroplasty are associated with the risk of long-term mortality in a cohort of patients with advanced OA of the… Continue reading Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
Age-related changes in #bone density, microarchitecture and strength in postmenopausal Black and White women: SWAN Longitudinal HR-pQCT Study
Higher fracture risk in White versus Black women is partly explained by lower BMD and worse bone microarchitecture in White women. However, whether rates of decline in bone density, microarchitecture and strength differ between postmenopausal Black and White women is unknown. Further, factors that influence rates of age-related bone microarchitecture deterioration remain ill-defined. Thus, over… Continue reading Age-related changes in #bone density, microarchitecture and strength in postmenopausal Black and White women: SWAN Longitudinal HR-pQCT Study
#Bone mineral density and bone turnover ten years after a single 5mg dose or two 5-yearly lower doses of #zoledronate in osteopenic older women: an open-label extension of a randomized controlled trial
Intravenous zoledronate reduces fracture risk (5mg at 18mo intervals) and prevents bone loss (doses of 1-5mg for 3 to >5y), but the duration of action of a single 5mg dose and the effects of lower doses beyond 5 years are unknown. We report the second open-label extension (years 5-10) of a 2y randomized, multidose, placebo-controlled, double-blinded… Continue reading #Bone mineral density and bone turnover ten years after a single 5mg dose or two 5-yearly lower doses of #zoledronate in osteopenic older women: an open-label extension of a randomized controlled trial
Evidence of a Causal Relationship between Serum #Thyroid-Stimulating Hormone and #Osteoporotic Bone Fractures
We aimed to validate the association of genome-wide association study (GWAS)-identified loci and polygenic risk score with serum thyroid-stimulating hormone (TSH) concentrations and the diagnosis of hypothyroidism. Then, the causal relationship between serum TSH and osteoporotic bone fracture risk was tested. Methods: A cross-sectional study was done among patients of European Caucasian ethnicity recruited in… Continue reading Evidence of a Causal Relationship between Serum #Thyroid-Stimulating Hormone and #Osteoporotic Bone Fractures
Effect of #meteorological factors and air #pollutants on #fractures: a nationwide population-based ecological study
To determine the association of meteorological factors and air pollutants (MFAPs) with fracture and to estimate the effect size/time lag. Design This is a nationwide population-based ecological study from 2008 to 2017. Setting Eight large metropolitan areas in Korea. Participants Of 8 093 820 patients with fractures reported in the Korea National Health Insurance database, 2 129 955 were… Continue reading Effect of #meteorological factors and air #pollutants on #fractures: a nationwide population-based ecological study
Longitudinal Analysis of Circulating Markers of #Bone Turnover Across Multiple Decades in #Osteoporotic Women
The objective of this study was to analyze changes in serum markers of bone turnover across multiple decades in osteoporotic women compared with nonosteoporotic controls, to determine their utility as potential predictors for osteoporosis. Early prediction of those at risk for osteoporosis can enable early intervention before the irreversible loss of critical bone mass. MethodsSerum… Continue reading Longitudinal Analysis of Circulating Markers of #Bone Turnover Across Multiple Decades in #Osteoporotic Women
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