Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

Osteoarthritis is a common condition, but curative therapies are limited. Here, Liu and colleagues developed a biodegradable scaffold using PLLA [poly(L-lactic acid)] nanofibers that when placed under applied force generated a piezoelectric charge, leading to improved chondrogenesis in vitro. Rabbits with osteochondral defects in the medial femoral condyle that were treated with the PLLA scaffold …

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#Bile Acids Signal via TGR5 to Activate #Intestinal Stem Cells and Epithelial Regeneration

Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nutrient availability by activating the G protein-coupled bile acid receptor 1 (GPBAR1, also called TGR5). TGR5 is expressed in the …

Continue reading #Bile Acids Signal via TGR5 to Activate #Intestinal Stem Cells and Epithelial Regeneration