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Category: Orthopedy
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone loss. In this study, we… Continue reading SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Axial alignment is a critical regulator of knee osteoarthritis
Taking a load offOsteoarthritis (OA) is characterized by subchondral bone thickening in addition to cartilage degeneration. Here, Oláh et al. studied the role of joint alignment in OA development. Unloading the knee joint of a patient with OA with varus malalignment by high tibial osteotomy, which corrected axial malalignment, improved pain and cartilage microstructure and… Continue reading Axial alignment is a critical regulator of knee osteoarthritis
Association of Lithium Treatment With the Risk of Osteoporosis in Patients With Bipolar Disorder
Importance Osteoporosis, a systemic skeletal disorder associated with substantial morbidity and mortality, may be particularly common among individuals with bipolar disorder. Lithium, a first-line mood-stabilizing treatment for bipolar disorder, may have bone-protecting properties. Objective To evaluate if treatment with lithium is associated with a decrease in risk of osteoporosis among patients with bipolar disorder. Design,… Continue reading Association of Lithium Treatment With the Risk of Osteoporosis in Patients With Bipolar Disorder
Digit ratios and their asymmetries as risk factors of developmental instability and hospitalization for COVID-19
COVID-19 presents with mild symptoms in the majority of patients but in a minority it progresses to acute illness and hospitalization. Here we consider whether markers for prenatal sex hormones and postnatal stressors on developmental instability, i.e. digit ratios and their directional and unsigned asymmetries, are predictive of hospitalization. We focus on six ratios: 2D:3D;… Continue reading Digit ratios and their asymmetries as risk factors of developmental instability and hospitalization for COVID-19
Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits
Osteoarthritis is a common condition, but curative therapies are limited. Here, Liu and colleagues developed a biodegradable scaffold using PLLA [poly(L-lactic acid)] nanofibers that when placed under applied force generated a piezoelectric charge, leading to improved chondrogenesis in vitro. Rabbits with osteochondral defects in the medial femoral condyle that were treated with the PLLA scaffold… Continue reading Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits
Are biomechanics during gait associated with the structural disease onset and progression of lower limb osteoarthritis? A systematic review and meta-analysis
To evaluate if gait biomechanics are associated with increased risk of structurally diagnosed disease onset or progression of lower limb osteoarthritis (OA). MethodA systematic review of Medline and Embase was conducted from inception to July 2021. Two reviewers independently screened records, extracted data and assessed risk of bias. Included studies reported gait biomechanics at baseline,… Continue reading Are biomechanics during gait associated with the structural disease onset and progression of lower limb osteoarthritis? A systematic review and meta-analysis
Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis
Scalable knee osteoarthritis programs are needed to deliver recommended education, exercise, and weight loss interventions. Objective:To evaluate two 6-month, telehealth-delivered exercise programs, 1 with and 1 without dietary intervention. Design:3-group, parallel randomized (5:5:2) trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000930280) Setting:Australian private health insurance members. Participants:415 persons with symptomatic knee osteoarthritis and a body… Continue reading Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis
Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
To investigate whether osteoarthritis (OA)–specific assessment values (i.e. Western Ontario and McMaster University Osteoarthritis Index [WOMAC]) and generic pain and function (visual analog scale [VAS], Hanover Functionality Status Questionnaire [FFbH]) measured before and 12 months after arthroplasty are associated with the risk of long-term mortality in a cohort of patients with advanced OA of the… Continue reading Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
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