The lifetime risk of dementia after age 55 years was 42% (95% confidence interval: 41–43). Rates were substantially higher in women, Black adults and APOE ε4 carriers, with lifetime risks ranging from approximately 45% to 60% in these populations. The number of US adults who will develop dementia each year was projected to increase from approximately… Continue reading Lifetime risk and projected burden of #dementia
Category: Neurology
The massed-spaced #learning effect in non-neural human #cells
The massed-spaced effect is a hallmark feature of memory formation. We now demonstrate this effect in two separate non-neural, immortalized cell lines stably expressing a short-lived luciferase reporter controlled by a CREB-dependent promoter. We emulate training using repeated pulses of forskolin and/or phorbol ester, and, as a proxy for memory, measure luciferase expression at various… Continue reading The massed-spaced #learning effect in non-neural human #cells
Membrane potential states gate #synaptic consolidation in human neocortical tissue
Synaptic mechanisms that contribute to human memory consolidation remain largely unexplored. Consolidation critically relies on sleep. During slow wave sleep, neurons exhibit characteristic membrane potential oscillations known as UP and DOWN states. Coupling of memory reactivation to these slow oscillations promotes consolidation, though the underlying mechanisms remain elusive. Here, we performed axonal and multineuron patch-clamp… Continue reading Membrane potential states gate #synaptic consolidation in human neocortical tissue
Short #Sleep Duration and #Hypertension: A Double Hit for the #Brain
Short sleep duration has been associated with an increased risk of cognitive impairment and dementia. Short sleep is associated with elevated blood pressure, yet the combined insult of short sleep and hypertension on brain health remains unclear. We assessed whether the association of sleep duration with cognition and vascular brain injury was moderated by hypertensive… Continue reading Short #Sleep Duration and #Hypertension: A Double Hit for the #Brain
#Propranolol Reduces #Parkinson’s #Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial
AbstractObjectiveParkinson's disease (PD) resting tremor is thought to be initiated in the basal ganglia and amplified in the cerebello-thalamo-cortical circuit. Because stress worsens tremor, the noradrenergic system may play a role in amplifying tremor. We tested if and how propranolol, a non-selective beta-adrenergic receptor antagonist, reduces PD tremor and whether or not this effect is… Continue reading #Propranolol Reduces #Parkinson’s #Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial
Blood #Pressure Variability and #Cognition in Black and White Older Adults Over 18 Years of Follow-up
Background and ObjectivesHypertension is a well-established cardiovascular risk factor for cognitive function. As blood pressure fluctuates because of aging-related changes, we examined the association between visit-to-visit blood pressure variability (BPV) and cognition in older adults. MethodsThis prospective observational cohort study included 4,770 individuals aged older than 65 years with repeated blood pressure assessment participating in… Continue reading Blood #Pressure Variability and #Cognition in Black and White Older Adults Over 18 Years of Follow-up
Identifying Early Predictors of #Cognitive Impairment and Dementia in a Large Nationally Representative U.S. Sample
The authors predicted quantitatively meaningful and statistically significant variation in dementia prevalence among persons approximately age 80 according to individuals' observed characteristics when they were about age 60.An individual's baseline cognitive abilities, health, and functional limitations are the strongest predictors of dementia, whereas parental health, family size, marital history, and demographics are the weakest ones.Having… Continue reading Identifying Early Predictors of #Cognitive Impairment and Dementia in a Large Nationally Representative U.S. Sample
Use of common #cardiovascular disease drugs and risk of #dementia: A case–control study in Swedish national register data
Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case–control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia.METHODSFrom the Swedish national registers, we included 88,065 incident dementia cases aged ≥ 70 at diagnosis between 2011 and 2016 and 880,650 age- and… Continue reading Use of common #cardiovascular disease drugs and risk of #dementia: A case–control study in Swedish national register data
#Cardiovascular risk and #obesity impact loss of grey matter volume earlier in males than females
Background It remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype mediates this relationship. Here we perform a large-scale evaluation of the influence of cardiovascular risk and obesity on brain volume in males and females in different age groups.Methods 34… Continue reading #Cardiovascular risk and #obesity impact loss of grey matter volume earlier in males than females
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