Sleep disorders may lead to hearing loss.• Complex relationship between sleep quality, auditory sense and mental health.• Oxidative stress and immune response may be potential mechanisms.• Current treatment strategies are limited and separate. AbstractThe intricate relationship between sleep disorders and hearing loss emerges as a burgeoning field of scholarly inquiry. Numerous studies have illuminated a… Continue reading #Echoes in the night: How #sleep quality influences #auditory health
Category: Neurology
The overlooked trio: #sleep duration, sampling time and #physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk
Biomarker profiling from biofluids such as blood are widely measured in clinical research, using for example Olink proteomics panels. One such research focus area is cardiovascular disease (CVD), for which chronic sleep restriction (SR) is a risk factor. However, it remains unclear whether blood levels of commonly measured CVD biomarkers are sensitive to acute dynamic… Continue reading The overlooked trio: #sleep duration, sampling time and #physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk
Increased #sedentary behavior is associated with #neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
INTRODUCTIONSedentary behavior may be a modifiable risk factor for Alzheimer's disease (AD). We examined how sedentary behavior relates to longitudinal brain structure and cognitive changes in older adults.METHODSVanderbilt Memory and Aging Project participants (n = 404) completed actigraphy (7 days), neuropsychological assessment, and 3T brain MRI over a 7-year period. Cross-sectional and longitudinal linear regressions… Continue reading Increased #sedentary behavior is associated with #neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
#Vagus nerve stimulation therapy for treatment-resistant #PTSD
BackgroundPosttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We developed a fundamentally novel neuromodulation-based therapy for treatment-resistant PTSD. This approach is premised on coupling prolonged exposure therapy, a first-line evidence-based cognitive behavioral therapy that directs changes within fear networks, with concurrent delivery of short bursts of… Continue reading #Vagus nerve stimulation therapy for treatment-resistant #PTSD
Multimodal population study reveals the neurobiological underpinnings of #chronotype
The rapid shifts in society have altered human behavioural patterns, with increased evening activities, increased screen time and changed sleep schedules. As an explicit manifestation of circadian rhythms, chronotype is closely intertwined with physical and mental health. Night owls often exhibit unhealthier lifestyle habits, are more susceptible to mood disorders and have poorer physical fitness… Continue reading Multimodal population study reveals the neurobiological underpinnings of #chronotype
Association Between #Alcohol Consumption, #Cognitive Abilities, and Neuropathologic Changes
Background and ObjectivesHeavy alcohol consumption is a major global health concern linked to increased morbidity and mortality. However, the long-term impact of excessive alcohol consumption on cognitive abilities and dementia-related neuropathology is unclear. The aim of this study was to analyze the association between alcohol consumption and age-related neuropathologic outcomes in a population-based autopsy study.MethodsThis… Continue reading Association Between #Alcohol Consumption, #Cognitive Abilities, and Neuropathologic Changes
GLP-1RA and SGLT2i Medications for Type 2 #Diabetes and #Alzheimer Disease and Related Dementias
Importance The association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) and risk of Alzheimer disease and related dementias (ADRD) remains to be confirmed.Objective To assess the risk of ADRD associated with GLP-1RAs and SGLT2is in people with type 2 diabetes (T2D).Design, Setting, and Participants This target trial emulation study used electronic… Continue reading GLP-1RA and SGLT2i Medications for Type 2 #Diabetes and #Alzheimer Disease and Related Dementias
Marital status and risk of #dementia over 18 years: Surprising findings from the National Alzheimer’s Coordinating Center
Marital status is a potential risk/protective factor for adverse health outcomes. This study tested whether marital status was associated with dementia risk in older adults.METHODSParticipants (N = 24,107; Meanage = 71.79) were from the National Alzheimer's Coordinating Center. Cox regressions tested the association between baseline marital status and clinically ascertained dementia over up to 18… Continue reading Marital status and risk of #dementia over 18 years: Surprising findings from the National Alzheimer’s Coordinating Center
Lower slow wave #sleep and rapid eye movement sleep are associated with brain #atrophy of AD-vulnerable regions
Study Objectives:Sleep deficiency is associated with Alzheimer’s disease (AD) pathogenesis. We examined the association of sleep architecture with anatomical features observed in AD: (1) atrophy of hippocampus, entorhinal, inferior parietal, parahippocampal, precuneus, and cuneus regions (“AD-vulnerable regions”) and (2) cerebral microbleeds.Methods:In 270 participants of the Atherosclerosis Risk in the Communities Study, we examined the association… Continue reading Lower slow wave #sleep and rapid eye movement sleep are associated with brain #atrophy of AD-vulnerable regions
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