This study explores the neural and behavioral consequences of LLM-assisted essay writing. Participants were divided into three groups: LLM, Search Engine, and Brain-only (no tools). Each completed three sessions under the same condition. In a fourth session, LLM users were reassigned to Brain-only group (LLM-to-Brain), and Brain-only users were reassigned to LLM condition (Brain-to-LLM). A… Continue reading Your #Brain on ChatGPT: Accumulation of #Cognitive Debt when Using an #AI Assistant for Essay Writing Task
Category: Neurology
Active #Travel Mode and Incident #Dementia and #Brain Structure
Importance Active travel modes, such as walking and cycling, are feasible and readily embraced forms of physical activity, but their association with dementia risk and brain structure remains unclear.Objectives To investigate the long-term association between travel modes and dementia risk and brain structural metrics and to evaluate whether genetic predisposition could modify the association between… Continue reading Active #Travel Mode and Incident #Dementia and #Brain Structure
Contribution of Modifiable Midlife and Late-Life #Vascular Risk Factors to Incident #Dementia
Importance Midlife vascular risk factors are associated with an elevated risk of dementia. However, the total contribution of vascular risk factors in midlife and late life with incident dementia is uncertain.Objective To quantify the proportion of incident dementia attributable to modifiable vascular risk factors measured in midlife and late life and to examine differences by… Continue reading Contribution of Modifiable Midlife and Late-Life #Vascular Risk Factors to Incident #Dementia
#Echoes in the night: How #sleep quality influences #auditory health
Sleep disorders may lead to hearing loss.• Complex relationship between sleep quality, auditory sense and mental health.• Oxidative stress and immune response may be potential mechanisms.• Current treatment strategies are limited and separate. AbstractThe intricate relationship between sleep disorders and hearing loss emerges as a burgeoning field of scholarly inquiry. Numerous studies have illuminated a… Continue reading #Echoes in the night: How #sleep quality influences #auditory health
The overlooked trio: #sleep duration, sampling time and #physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk
Biomarker profiling from biofluids such as blood are widely measured in clinical research, using for example Olink proteomics panels. One such research focus area is cardiovascular disease (CVD), for which chronic sleep restriction (SR) is a risk factor. However, it remains unclear whether blood levels of commonly measured CVD biomarkers are sensitive to acute dynamic… Continue reading The overlooked trio: #sleep duration, sampling time and #physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk
Increased #sedentary behavior is associated with #neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
INTRODUCTIONSedentary behavior may be a modifiable risk factor for Alzheimer's disease (AD). We examined how sedentary behavior relates to longitudinal brain structure and cognitive changes in older adults.METHODSVanderbilt Memory and Aging Project participants (n = 404) completed actigraphy (7 days), neuropsychological assessment, and 3T brain MRI over a 7-year period. Cross-sectional and longitudinal linear regressions… Continue reading Increased #sedentary behavior is associated with #neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
#Vagus nerve stimulation therapy for treatment-resistant #PTSD
BackgroundPosttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We developed a fundamentally novel neuromodulation-based therapy for treatment-resistant PTSD. This approach is premised on coupling prolonged exposure therapy, a first-line evidence-based cognitive behavioral therapy that directs changes within fear networks, with concurrent delivery of short bursts of… Continue reading #Vagus nerve stimulation therapy for treatment-resistant #PTSD
Multimodal population study reveals the neurobiological underpinnings of #chronotype
The rapid shifts in society have altered human behavioural patterns, with increased evening activities, increased screen time and changed sleep schedules. As an explicit manifestation of circadian rhythms, chronotype is closely intertwined with physical and mental health. Night owls often exhibit unhealthier lifestyle habits, are more susceptible to mood disorders and have poorer physical fitness… Continue reading Multimodal population study reveals the neurobiological underpinnings of #chronotype
Association Between #Alcohol Consumption, #Cognitive Abilities, and Neuropathologic Changes
Background and ObjectivesHeavy alcohol consumption is a major global health concern linked to increased morbidity and mortality. However, the long-term impact of excessive alcohol consumption on cognitive abilities and dementia-related neuropathology is unclear. The aim of this study was to analyze the association between alcohol consumption and age-related neuropathologic outcomes in a population-based autopsy study.MethodsThis… Continue reading Association Between #Alcohol Consumption, #Cognitive Abilities, and Neuropathologic Changes
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