Introduction: This study explores the potential associations between COVID-19 vaccination and neuropsychiatric conditions. Methods: Data were collected from the CDC and FDA. The VAERS database was queried from January 1, 1990, to December 27, 2024, for adverse events (AEs) involving neuropsychiatric complications following COVID-19 vaccination. The timeframe included 420 months for all vaccines except COVID-19… Continue reading Association Between #COVID-19 #Vaccination and #Neuropsychiatric Conditions
Category: Neurology
Classification of #Parkinson’s disease and isolated #REM sleep behaviour disorder: delineating progression markers from the sebum volatilome
Parkinson’s Disease (PD) has been associated with a distinct odour, emanating from the skin and strongest in sebum-rich areas. Here, volatile components from sebum were analysed directly with Thermal Desorption Gas Chromatography - Mass Spectrometry. We analysed samples from subjects with clinically established PD (n = 46), controls (n = 28) and participants with isolated REM sleep behaviour disorder… Continue reading Classification of #Parkinson’s disease and isolated #REM sleep behaviour disorder: delineating progression markers from the sebum volatilome
Effects of various #exercise interventions in #insomnia patients: a systematic review and network meta-analysis
Objectives To compare the effectiveness of different exercise interventions in improving sleep quality and alleviating insomnia severity among patients with insomnia.Design Our study design was a systematic review and network meta-analysis.Eligibility criteria Our study eligibility criteria was restricted to include randomised controlled trials (RCTs) involving adults with insomnia that evaluated exercise-based interventions.Data sources PubMed, Cochrane… Continue reading Effects of various #exercise interventions in #insomnia patients: a systematic review and network meta-analysis
Association of #Egg Intake With #Alzheimer’s #Dementia Risk in #Older Adults: The Rush #Memory and Aging Project
BackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder with increasing prevalence due to population aging. Eggs provide many nutrients important for brain health, including choline, omega-3 fatty acids, and lutein. Emerging evidence suggests that frequent egg consumption may improve cognitive performance on verbal tests, but whether consumption influences the risk of Alzheimer’s dementia and AD is… Continue reading Association of #Egg Intake With #Alzheimer’s #Dementia Risk in #Older Adults: The Rush #Memory and Aging Project
#AI -guided patient stratification improves outcomes and efficiency in the AMARANTH #Alzheimer’s Disease clinical trial
Alzheimer’s Disease (AD) drug discovery has been hampered by patient heterogeneity, and the lack of sensitive tools for precise stratification. Here, we demonstrate that our robust and interpretable AI-guided tool (predictive prognostic model, PPM) enhances precision in patient stratification, improving outcomes and decreasing sample size for a AD clinical trial. The AMARANTH trial of lanabecestat,… Continue reading #AI -guided patient stratification improves outcomes and efficiency in the AMARANTH #Alzheimer’s Disease clinical trial
Association between dietary #copper intake and #cognitive function in American older adults: NHANES 2011–2014
This cross-sectional observational study examined the association between dietary copper intake and cognitive function in American older adults, using data from the 2011 to 2014 National Health and Nutrition Examination Survey (NHANES). Analyzing a total of 2420 participants, dietary copper intake was determined by averaging two 24-h dietary recalls, whereas cognitive function was assessed by… Continue reading Association between dietary #copper intake and #cognitive function in American older adults: NHANES 2011–2014
Risk of #dementia following #gabapentin prescription in chronic low back #pain patients
Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain.Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024.… Continue reading Risk of #dementia following #gabapentin prescription in chronic low back #pain patients
#Mind #Wandering during Implicit #Learning Is Associated with Increased Periodic #EEG Activity and Improved Extraction of Hidden Probabilistic Patterns
Mind wandering, occupying 30–50% of our waking time, remains an enigmatic phenomenon in cognitive neuroscience. A large number of studies showed a negative association between mind wandering and attention-demanding (model-based) tasks in both natural settings and laboratory conditions. Mind wandering, however, does not seem to be detrimental for all cognitive domains and was observed to… Continue reading #Mind #Wandering during Implicit #Learning Is Associated with Increased Periodic #EEG Activity and Improved Extraction of Hidden Probabilistic Patterns
#Ambroxol as a #Treatment for #Parkinson Disease #DementiaA Randomized Clinical Trial
Importance Carrying a variation in the gene for β-glucocerebrosidase is a major risk factor for Parkinson disease dementia (PDD), and raising β-glucocerebrosidase levels lowers α-synuclein in cell and animals. Ambroxol is a chaperone for β-glucocerebrosidase, which increases the levels of β-glucocerebrosidase.Objective To examine the safety and tolerability of ambroxol in PDD, test the efficacy of… Continue reading #Ambroxol as a #Treatment for #Parkinson Disease #DementiaA Randomized Clinical Trial
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