The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. It was computationally reconstructed for the first time to the level of all individual folia from multicontrast high-resolution postmortem MRI scans. Its total shrinkage-corrected surface area (1,590 cm2) was larger than expected or previously reported, equal to 78% of… Continue reading The human #cerebellum has almost 80% of the surface area of the #neocortex
Category: Neurology
Conservation of #brain connectivity and wiring across the mammalian class
Over 100 years ago, Ramon y Cajal hypothesized that two forces played a role in the evolution of mammalian brain connectivity: minimizing wiring costs and maximizing conductivity speed. Using diffusion MRI, we reconstructed the brain connectomes of 123 mammalian species. Network analysis revealed that both connectivity and the wiring cost are conserved across mammals. We… Continue reading Conservation of #brain connectivity and wiring across the mammalian class
Complementary contributions of non-REM and #REM sleep to visual #learning
Sleep is beneficial for learning. However, it remains unclear whether learning is facilitated by non-rapid eye movement (NREM) sleep or by REM sleep, whether it results from plasticity increases or stabilization, and whether facilitation results from learning-specific processing. Here, we trained volunteers on a visual task and measured the excitatory and inhibitory (E/I) balance in… Continue reading Complementary contributions of non-REM and #REM sleep to visual #learning
Nine-year prospective efficacy and safety of brain-responsive #neurostimulation for focal #epilepsy
Prospectively evaluate safety and efficacy of brain-responsive neurostimulation in adults with medically intractable focal onset seizures (FOS) over 9 years.. Adults treated with brain-responsive neurostimulation within 2 year feasibility or randomized controlled trials enrolled into a long-term prospective open label trial (LTT) to assess safety, efficacy, and quality of life (QOL) over an additional 7… Continue reading Nine-year prospective efficacy and safety of brain-responsive #neurostimulation for focal #epilepsy
The temporal association between incident late‐life #depression and incident #dementia
There is an established association between depression and subsequent dementia. The present study examined temporal associations between incident late‐life depression and subsequent dementia, also considering age and sex.. ..Incident depression was associated with a higher risk of subsequent dementia (incidence rate ratios (IRR) adjusted for age and sex: IRR = 1.58, 95% CI = 1.51‐1.64).… Continue reading The temporal association between incident late‐life #depression and incident #dementia
Risk factors of excessive daytime #sleepiness in a prospective population‐based cohort
Although excessive daytime sleepiness is commonly evaluated in clinical and research settings using the Epworth Sleepiness Scale, few studies have assessed the factors associated with its incidence in the general population. We prospectively investigated the predictors of incident and persistent excessive daytime sleepiness in 2,751 subjects (46.1% men, mean age 56.0 ± 9.8 years) from… Continue reading Risk factors of excessive daytime #sleepiness in a prospective population‐based cohort
#Cerebrovascular and Neurological Dysfunction under the Threat of #COVID-19: Is There a Comorbid Role for #Smoking and Vaping?
The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic was associated with causing severe pulmonary and respiratory disorders, recent case studies reported the association of cerebrovascular-neurological dysfunction in COVID-19 patients, which is also life-threatening. Several… Continue reading #Cerebrovascular and Neurological Dysfunction under the Threat of #COVID-19: Is There a Comorbid Role for #Smoking and Vaping?
#Sleep patterns and #insomnia in a large population‐based study of middle‐aged and older adults: The Tromsø study 2015–2016
Epidemiological studies assessing adult sleep duration have yielded inconsistent findings and there are still large variations in estimation of insomnia prevalence according to the most recent diagnostic criteria. Our objective was to describe sleep patterns in a large population of middle‐aged and older adults, by employing accurate measures of both sleep duration and insomnia. Data… Continue reading #Sleep patterns and #insomnia in a large population‐based study of middle‐aged and older adults: The Tromsø study 2015–2016
Circulating asymmetric #dimethylarginine and #cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort
The underlying mechanisms leading to dementia and Alzheimer’s disease (AD) are unclear. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be associated with cognitive decline, but population‐based evidence is lacking.. ..Change in cognitive performance was assessed in participants of the Aberdeen Birth Cohort of 1936 using longitudinal Raven’s progressive matrices (RPM) between… Continue reading Circulating asymmetric #dimethylarginine and #cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort
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