Epidemiological studies assessing adult sleep duration have yielded inconsistent findings and there are still large variations in estimation of insomnia prevalence according to the most recent diagnostic criteria. Our objective was to describe sleep patterns in a large population of middle‐aged and older adults, by employing accurate measures of both sleep duration and insomnia. Data… Continue reading #Sleep patterns and #insomnia in a large population‐based study of middle‐aged and older adults: The Tromsø study 2015–2016
Category: Neurology
Circulating asymmetric #dimethylarginine and #cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort
The underlying mechanisms leading to dementia and Alzheimer’s disease (AD) are unclear. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be associated with cognitive decline, but population‐based evidence is lacking.. ..Change in cognitive performance was assessed in participants of the Aberdeen Birth Cohort of 1936 using longitudinal Raven’s progressive matrices (RPM) between… Continue reading Circulating asymmetric #dimethylarginine and #cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort
Dual #sensory impairment in older adults and risk of #dementia from the GEM Study
Hearing and vision loss are independently associated with dementia, but the impact of dual sensory impairment (DSI) on dementia risk is not well understood.. ..DSI was significantly associated with higher risk of all‐cause dementia (hazard ratio [HR] = 1.86; 95% confidence interval [CI] = 1.25‐2.76) and Alzheimer's disease (HR = 2.12; 95% CI = 1.34‐3.36).… Continue reading Dual #sensory impairment in older adults and risk of #dementia from the GEM Study
Association of Rapid Eye Movement #Sleep With Mortality in Middle-aged and Older Adults
Rapid eye movement (#REM) sleep has been linked with health outcomes, but little is known about the relationship between REM sleep and mortality.. ..The MrOS cohort included 2675 individuals (2675 men [100%]; mean [SD] age, 76.3 [5.5] years) and was followed up for a median (interquartile range) of 12.1 (7.8-13.2) years. The WSC cohort included 1386… Continue reading Association of Rapid Eye Movement #Sleep With Mortality in Middle-aged and Older Adults
Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease
To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using… Continue reading Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease
Generative Feedback Explains Distinct Brain Activity Codes for Seen and Mental Images
The relationship between mental imagery and vision is a long-standing problem in neuroscience. Currently, it is not known whether differences between the activity evoked during vision and reinstated during imagery reflect different codes for seen and mental images. To address this problem, we modeled mental imagery in the human brain as feedback in a hierarchical… Continue reading Generative Feedback Explains Distinct Brain Activity Codes for Seen and Mental Images
Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro
Potential drug treatments for Alzheimer’s disease (AD) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and cell death. Here, a small library of structurally diverse compounds was screened in vitro for the ability to inhibit tau aggregation, using high-throughput synchrotron radiation… Continue reading Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro
Different predictors after stroke depending on functional dependency at discharge: a 5-year follow up study
Level of dependency after a stroke is important for long-term outcome in several aspects, but less is known about important predictors for outcome depending on functional dependency. The aim of the current study was to investigate self-perceived outcome and identify possible predictors of strength, participation, and emotional outcome 5 years after stroke based on functional… Continue reading Different predictors after stroke depending on functional dependency at discharge: a 5-year follow up study
Dynamic functional connectivity between nucleus accumbens and the central executive network relates to chronic cannabis use
The neural mechanisms of drug cue‐reactivity regarding the temporal fluctuations of functional connectivity, namely the dynamic connectivity, are sparsely studied. Quantifying the task‐modulated variability in dynamic functional connectivity at cue exposure can aid the understanding. We analyzed changes in dynamic connectivity in 54 adult cannabis users and 90 controls during a cannabis cue exposure task.… Continue reading Dynamic functional connectivity between nucleus accumbens and the central executive network relates to chronic cannabis use
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