Objective To evaluate the quality of evidence, potential biases, and validity of all available studies on dietary sugar consumption and health outcomes.Design Umbrella review of existing meta-analyses.Data sources PubMed, Embase, Web of Science, Cochrane Database of Systematic Reviews, and hand searching of reference lists.Inclusion criteria Systematic reviews and meta-analyses of randomised controlled trials, cohort studies,… Continue reading Dietary sugar consumption and health: umbrella review
Category: Neurology
Caffeine consumption as a risk factor for childhood and adolescence migraine
Background: Caffeine consumption is a risk factor for chronic daily headache but few studies have addressed relationships between pediatric patient caffeine levels and headache severity. We examined associations between serum and urine caffeine levels and headache severity in childhood and adolescent migraine cases.Methods: Levels of caffeine and caffeine metabolites in serum and urine samples were… Continue reading Caffeine consumption as a risk factor for childhood and adolescence migraine
Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers
The association between hypertension developed before midlife and late-life brain health is understudied and, because of the cardioprotective benefits of estrogen before menopause, may differ by sex. Objective To assess the association of early adulthood hypertension and blood pressure (BP) change with late-life neuroimaging biomarkers and examine potential sex differences. Design, Setting, and Participants This cohort study… Continue reading Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers
Sleep Patterns and the Risk of Acute Stroke: Results from the INTERSTROKE International Case-Control Study
Background and Objectives: Symptoms of sleep disturbance are common, and may represent important modifiable risk factors for stroke. We evaluated the association between a spectrum of sleep disturbance symptoms and risk of acute stroke in an international setting.Methods: INTERSTROKE is an international case-control study of patients presenting with first acute stroke and controls matched by… Continue reading Sleep Patterns and the Risk of Acute Stroke: Results from the INTERSTROKE International Case-Control Study
Trichloroethylene: An Invisible Cause of Parkinson’s Disease?
The etiologies of Parkinson’s disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common… Continue reading Trichloroethylene: An Invisible Cause of Parkinson’s Disease?
Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
Background and aimsObservational studies have linked elevated blood pressure (BP) to impaired cognitive function. However, the functional and structural changes in the brain that mediate the relationship between BP elevation and cognitive impairment remain unknown. Using observational and genetic data from large consortia, this study aimed to identify brain structures potentially associated with BP values… Continue reading Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
META-ANALYSIS: CLUSTER HEADACHE, MIGRAINE HAVE STRONG LINKS TO CIRCADIAN SYSTEM
...For cluster headache, the meta-analysis found a circadian pattern of headache attacks in 71% of people. Attacks peaked in the late hours of the night to early hours of the morning. During the year, people had more attacks in the spring and fall. On the genetic level, cluster headache was associated with two main circadian… Continue reading META-ANALYSIS: CLUSTER HEADACHE, MIGRAINE HAVE STRONG LINKS TO CIRCADIAN SYSTEM
Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
PurposeTo examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age.MethodsParticipants (aged 40–73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class… Continue reading Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
Physical exercise for people with Parkinson’s disease: a systematic review and network meta‐analysis
Physical exercise is effective in managing Parkinson's disease (PD), but the relative benefit of different exercise types remains unclear.ObjectivesTo compare the effects of different types of physical exercise in adults with PD on the severity of motor signs, quality of life (QoL), and the occurrence of adverse events, and to generate a clinically meaningful treatment… Continue reading Physical exercise for people with Parkinson’s disease: a systematic review and network meta‐analysis
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