Hot Topics: Is sleep deprivation more dangerous than many people realise?

Although sleep is an essential and important part of human life, sleep loss has become a widespread problem in today’s fast-paced society. The modern way of life frequently extols efficiency and the capacity to function with little sleep, yet the negative effects of sleep deprivation are much more severe than most people think. Maintaining physical,… Continue reading Hot Topics: Is sleep deprivation more dangerous than many people realise?

The Importance of Consistent Sleep Habits in Slowing Down the Aging Process

Consistent Sleep Habits Shown to Slow Down Aging Process, Study Finds A recent study conducted by researchers at Augusta University in the United States has revealed the significant impact of maintaining consistent sleep habits on overall health and aging. The findings suggest that a regular sleep routine not only benefits cognitive processes such as thinking… Continue reading The Importance of Consistent Sleep Habits in Slowing Down the Aging Process

Incidence of adverse #cardiovascular events in patients with #insomnia: A systematic review and meta-analysis of real-world data

Insomnia is a prevalent sleeping disorder associated with increasing cardiovascular (CV) mortality and morbidity. However, data incorporating recent clinical studies evaluating these outcomes is scarce. Hence, we aimed to investigate the association of insomnia with CV mortality, myocardial infarction (MI), all-cause mortality, and incidence of CV disease by conducting the first-ever meta-analysis of real-world data… Continue reading Incidence of adverse #cardiovascular events in patients with #insomnia: A systematic review and meta-analysis of real-world data

Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice 

Caffeine has significant effects on neurovascular activity and behavior throughout the sleep–wake cycle. We used a minimally invasive microchip/video system to continuously record effects of caffeine in the drinking water of freely behaving mice. Chronic caffeine shifted both rest and active phases by up to 2 h relative to the light–dark cycle in a dose-dependent fashion.… Continue reading Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice 

#Dementia Risk of Direct Oral Anticoagulants Versus Warfarin for Atrial #Fibrillation: Systematic Review and Meta-Analysis

BackgroundDirect-acting oral anticoagulants (DOACs) have demonstrated superior efficacy in preventing stroke and death compared with warfarin in patients with atrial fibrillation (AF), but their influence on dementia risk remains unclear.ObjectivesThe purpose of this study was to evaluate the relative risks of dementia in DOAC vs warfarin in patients with AF.MethodsAn electronic literature search was conducted… Continue reading #Dementia Risk of Direct Oral Anticoagulants Versus Warfarin for Atrial #Fibrillation: Systematic Review and Meta-Analysis

PRAC recommends new measures to avoid #topiramate exposure in #pregnancy

Further restrictions on use; pregnancy prevention programme to be put in placeEMA’s safety committee (PRAC) recommends new measures to avoid exposure of children to topiramate-containing medicines in the womb, because the medicine may increase the risk of neurodevelopmental problems after exposure during pregnancy. Topiramate is already known to cause serious birth defects when used during… Continue reading PRAC recommends new measures to avoid #topiramate exposure in #pregnancy

Irisin reduces #amyloid-β by inducing the release of neprilysin from #astrocytes following downregulation of ERK-STAT3 signaling

A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β (Aβ) protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but the underlying mechanisms have not been elucidated. Irisin, an exercise-induced hormone, is the secreted form of fibronectin type-III-domain-containing 5 (FNDC5). Here, using a… Continue reading Irisin reduces #amyloid-β by inducing the release of neprilysin from #astrocytes following downregulation of ERK-STAT3 signaling