Dementia and hepatic encephalopathy (HE) are challenging to distinguish clinically. Undiagnosed cirrhosis in a patient with dementia can lead to missed opportunities to treat HE.Objective To examine the prevalence and risk factors of undiagnosed cirrhosis and therefore possible HE in veterans with dementia.Design, Setting, and Participants A retrospective cohort study was conducted between 2009 and 2019 using… Continue reading Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
Category: Neurology
The relationship between playing #musical instruments and #cognitive trajectories: Analysis from a UK ageing cohort
The accumulation of age-associated cognitive deficits can lead to Mild Cognitive Impairment (MCI) and dementia. This is a major public health issue for the modern ageing population, as it impairs health, independence and overall quality of life. Keeping the brain active during life has been associated with an increased cognitive reserve, therefore reducing the risk… Continue reading The relationship between playing #musical instruments and #cognitive trajectories: Analysis from a UK ageing cohort
Association Between Electronic Diary–Rated #Sleep, Mood, Energy, and #Stress With Incident #Headache in a Community-Based Sample
The aim of this study was to examine the diurnal links between average and changes in average levels of prospectively rated mood, sleep, energy, and stress as predictors of incident headache in a community-based sample.MethodsThis observational study included structured clinical diagnostic assessment of both headache syndromes and mental disorders and electronic diaries that were administered… Continue reading Association Between Electronic Diary–Rated #Sleep, Mood, Energy, and #Stress With Incident #Headache in a Community-Based Sample
#Statins and risks of #dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong
Heart failure (HF) and dementia frequently co-exist with shared pathological mechanisms and risk factors. Our study aims to investigate the association between statin therapy and the risks of dementia and its subtypes among patients with HF.MethodsThe Hong Kong Clinical Data Analysis and Reporting System database was interrogated to identify patients with incident HF diagnosis from… Continue reading #Statins and risks of #dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong
#Migraine is associated with the development of adult patients with inflammatory #bowel disease: a nationwide, population-based study
It has been reported that migraine is more common in patients with inflammatory bowel disease (IBD) than in general. However, the impact of migraine on the development of IBD has not yet been elucidated. The aim of this study was to determine the association between migraine and the development of IBD. This nationwide population-based cohort… Continue reading #Migraine is associated with the development of adult patients with inflammatory #bowel disease: a nationwide, population-based study
Long-term risk of #cardiovascular disease after traumatic #brain injury: screening and prevention
Traumatic brain injury (TBI) is highly prevalent among individuals participating in contact sports, military personnel, and in the general population. Although it is well known that brain injury can cause neurological and psychiatric complications, evidence from studies on individuals exposed to a single or repetitive brain injuries suggests an understudied association between TBI and the… Continue reading Long-term risk of #cardiovascular disease after traumatic #brain injury: screening and prevention
OXR1 maintains the retromer to delay brain #aging under #dietary restriction
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids.… Continue reading OXR1 maintains the retromer to delay brain #aging under #dietary restriction
#Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study
BackgroundDisturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer’s disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or other mechanisms.ObjectiveTo explore the association between the use of lipid-lowering medications and cognitive decline over time in a cohort of patients with AD or mixed dementia with… Continue reading #Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study
Effects of calibrated blue–yellow changes in light on the human #circadian clock
Evening exposure to short-wavelength light can affect the circadian clock, sleep and alertness. Intrinsically photosensitive retinal ganglion cells expressing melanopsin are thought to be the primary drivers of these effects. Whether colour-sensitive cones also contribute is unclear. Here, using calibrated silent-substitution changes in light colour along the blue–yellow axis, we investigated whether mechanisms of colour… Continue reading Effects of calibrated blue–yellow changes in light on the human #circadian clock
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