BACKGROUND:Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk factors throughout their life span has been limited. This prospective cohort study aims to determine the effect of body mass index (BMI) and its changes in adolescence and young adulthood on early onset cerebrovascular disease.METHODS:This study includes 10 491 people (5185… Continue reading #Overweight in #Adolescence and Young Adulthood in Association With Adult #Cerebrovascular Disease: The NFBC1966 Study
Category: Neurology
#Glucagon-like peptide-1 receptor agonists and #stroke: A systematic review and meta-analysis of #cardiovascular outcome trials
Background:In patients surviving stroke, approximately 15% and 60% exhibit concurrent diabetes mellitus and overweight/obesity, respectively, necessitating heightened secondary prevention efforts. Despite glucagon-like peptide-1 receptor agonists (GLP-1 RAs) demonstrating improved outcomes for those with diabetes mellitus or obesity, their underutilization persists among eligible individuals. This systematic review and meta-analysis investigated the impact of GLP-1 RAs on… Continue reading #Glucagon-like peptide-1 receptor agonists and #stroke: A systematic review and meta-analysis of #cardiovascular outcome trials
#Cerebrovascular Effects of #Sildenafil in Small Vessel Disease: The OxHARP Trial
BACKGROUND:Vascular cognitive impairment due to cerebral small vessel disease is associated with cerebral pulsatility, white matter hypoperfusion, and reduced cerebrovascular reactivity (CVR), and is potentially improved by endothelium-targeted drugs such as cilostazol. Whether sildenafil, a phosphodiesterase-5 inhibitor, improves cerebrovascular dysfunction is unknown.METHODS:OxHARP trial (Oxford Haemodynamic Adaptation to Reduce Pulsatility) was a double-blind, randomized, placebo-controlled, 3-way… Continue reading #Cerebrovascular Effects of #Sildenafil in Small Vessel Disease: The OxHARP Trial
Prescribed Drug Use and #Aneurysmal Subarachnoid #Hemorrhage IncidenceA Drug-Wide Association Study
Background and ObjectivesCurrent benefits of invasive intracranial aneurysm treatment to prevent aneurysmal subarachnoid hemorrhage (aSAH) rarely outweigh treatment risks. Most intracranial aneurysms thus remain untreated. Commonly prescribed drugs reducing aSAH incidence may provide leads for drug repurposing. We performed a drug-wide association study (DWAS) to systematically investigate the association between commonly prescribed drugs and aSAH… Continue reading Prescribed Drug Use and #Aneurysmal Subarachnoid #Hemorrhage IncidenceA Drug-Wide Association Study
#Thromboembolic events and vascular #dementia in patients with atrial #fibrillation and low apparent stroke risk
The prevention of thromboembolism in atrial fibrillation (AF) is typically restricted to patients with specific risk factors and ignores outcomes such as vascular dementia. This population-based cohort study used electronic healthcare records from 5,199,994 primary care patients (UK; 2005–2020). A total of 290,525 (5.6%) had a diagnosis of AF and were aged 40–75 years, of… Continue reading #Thromboembolic events and vascular #dementia in patients with atrial #fibrillation and low apparent stroke risk
Consumption of #fruits and #vegetables and its association with #sleep duration among Finnish adult population: a nationwide cross-sectional study
Introduction: Sleep and diet are crucial determinants of overall health and wellbeing, with the potential to mutually influence each other. This study examined the association between sleep duration and fruits and vegetables (FV) consumption among Finnish adults.Methods: The study analyzed data from the National FinHealth 2017 Study involving 5,043 adults aged 18 years and above. Participants reported… Continue reading Consumption of #fruits and #vegetables and its association with #sleep duration among Finnish adult population: a nationwide cross-sectional study
Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory
Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM… Continue reading Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory
The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity
BackgroundInflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. LRRK2 has been implicated as playing a role in both diseases. Exploring the genetic basis of the IBD-PD comorbidity through studying high-impact rare genetic variants can facilitate the identification of the novel shared genetic factors underlying this… Continue reading The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity
Consumption of #Olive Oil and Diet Quality and Risk of #Dementia-Related Death
Question Is the long-term consumption of olive oil associated with dementia-related death risk? Findings In a prospective cohort study of 92 383 adults observed over 28 years, the consumption of more than 7 g/d of olive oil was associated with a 28% lower risk of dementia-related death compared with never or rarely consuming olive oil, irrespective of diet… Continue reading Consumption of #Olive Oil and Diet Quality and Risk of #Dementia-Related Death
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