Importance Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, distance and near visual acuity and contrast sensitivity) in a nationally representative sample of older adults.Objective To quantify population attributable fractions of dementia… Continue reading #Vision Impairment and the Population Attributable Fraction of #Dementia in Older #Adults
Category: Neurology
Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Lifestyle habits after middle age significantly impact the maintenance of cognitive function in older adults. Nutritional intake is closely related to lifestyle habits; therefore, nutrition is a pivotal factor in the prevention of dementia in the preclinical stages. Matcha green tea powder (matcha), which contains epigallocatechin gallate, theanine, and caffeine, has beneficial effects on cognitive… Continue reading Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
Background and ObjectivesPreclinical studies suggest that acute kidney injury (AKI) results in biochemical and pathologic changes in the brain. We aimed to explore the association between experiencing AKI and subsequent risks of developing dementia.MethodsWe conducted a study involving individuals aged 65 years and older in Stockholm from 2006 to 2019, who were free from dementia… Continue reading Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) have more brain white matter lesions (WMLs), an association suggesting that small-vessel ischemic disease, a major contributor to the development of dementia, including Alzheimer disease, may be preventable through ω-3 treatment.Objective To… Continue reading ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Editor’s summaryDuring sleep, there is an increase in the coordinated firing of neuronal ensembles that were previously active during behavior. These hippocampal sharp-wave ripples are necessary for sleep-dependent memory consolidation. However, how the hippocampus regulates such increases in ensemble reactivation and synchrony while keeping the overall homeostatic balance of the network is not known. Karaba et… Continue reading A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
Importance Traumatic brain injuries (TBI) represent an important, potentially modifiable risk factor for dementia. Despite frequently observed vascular imaging changes in individuals with TBI, the relationships between TBI-associated changes in brain imaging and clinical outcomes have largely been overlooked in community cases of TBI.Objective To assess whether TBI are associated with and interact with midlife changes in… Continue reading Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
The #dopaminergic system promotes neprilysin-mediated degradation of #amyloid-β in the brain
Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to cognitive decline in Alzheimer’s disease (AD). Here, we found that dopamine and the dopamine precursor levodopa (also called l-DOPA) induced Aβ degradation in the brain. Chemogenetic approaches in mice revealed that the activation of dopamine release from ventral tegmental area (VTA) neurons… Continue reading The #dopaminergic system promotes neprilysin-mediated degradation of #amyloid-β in the brain
Higher #Coffee Consumption Is Associated With Slower #Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
AbstractBackground: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer's disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any… Continue reading Higher #Coffee Consumption Is Associated With Slower #Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
Comparing Migraine Headache Index versus Monthly #Migraine Days after #Headache Surgery: A Systematic Review and Meta-Analysis
Background: Nerve deactivation surgery for the treatment of migraine has evolved rapidly over the past 2 decades. Studies typically report changes in migraine frequency (attacks/month), attack duration, attack intensity, and their composite score—the Migraine Headache Index—as primary outcomes. However, the neurology literature predominantly reports migraine prophylaxis outcomes as change in monthly migraine days (MMD). The goal… Continue reading Comparing Migraine Headache Index versus Monthly #Migraine Days after #Headache Surgery: A Systematic Review and Meta-Analysis
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