Objective To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults.Design Systematic review and network meta-analysis.Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.gov, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform, as well as websites of regulatory agencies and pharmaceutical companies without language restrictions until… Continue reading Comparative effects of drug interventions for the acute management of #migraine episodes in adults: systematic review and network meta-analysis
Category: Neurology
Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
Importance The gut-first hypothesis of Parkinson disease (PD) has gained traction, yet potential inciting events triggering Parkinson pathology from gut-related factors remain unclear. While Helicobacter pylori infection is linked to mucosal damage (MD) and PD, it is unknown how upper gastrointestinal MD from any source increases PD risk.Objective To evaluate any association between upper endoscopy findings of MD and… Continue reading Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
#Vision Impairment and the Population Attributable Fraction of #Dementia in Older Adults
Importance Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, distance and near visual acuity and contrast sensitivity) in a nationally representative sample of older adults.Objective To quantify population attributable fractions of dementia… Continue reading #Vision Impairment and the Population Attributable Fraction of #Dementia in Older Adults
#Vision Impairment and the Population Attributable Fraction of #Dementia in Older #Adults
Importance Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, distance and near visual acuity and contrast sensitivity) in a nationally representative sample of older adults.Objective To quantify population attributable fractions of dementia… Continue reading #Vision Impairment and the Population Attributable Fraction of #Dementia in Older #Adults
Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Lifestyle habits after middle age significantly impact the maintenance of cognitive function in older adults. Nutritional intake is closely related to lifestyle habits; therefore, nutrition is a pivotal factor in the prevention of dementia in the preclinical stages. Matcha green tea powder (matcha), which contains epigallocatechin gallate, theanine, and caffeine, has beneficial effects on cognitive… Continue reading Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
Background and ObjectivesPreclinical studies suggest that acute kidney injury (AKI) results in biochemical and pathologic changes in the brain. We aimed to explore the association between experiencing AKI and subsequent risks of developing dementia.MethodsWe conducted a study involving individuals aged 65 years and older in Stockholm from 2006 to 2019, who were free from dementia… Continue reading Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) have more brain white matter lesions (WMLs), an association suggesting that small-vessel ischemic disease, a major contributor to the development of dementia, including Alzheimer disease, may be preventable through ω-3 treatment.Objective To… Continue reading ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Editor’s summaryDuring sleep, there is an increase in the coordinated firing of neuronal ensembles that were previously active during behavior. These hippocampal sharp-wave ripples are necessary for sleep-dependent memory consolidation. However, how the hippocampus regulates such increases in ensemble reactivation and synchrony while keeping the overall homeostatic balance of the network is not known. Karaba et… Continue reading A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
Importance Traumatic brain injuries (TBI) represent an important, potentially modifiable risk factor for dementia. Despite frequently observed vascular imaging changes in individuals with TBI, the relationships between TBI-associated changes in brain imaging and clinical outcomes have largely been overlooked in community cases of TBI.Objective To assess whether TBI are associated with and interact with midlife changes in… Continue reading Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
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