ObjectivesTo determine the association between early midlife sleep and advanced brain aging patterns in late midlife.MethodsUsing the CARDIA study, we analyzed sleep data at baseline and 5 years later, focusing on short sleep duration, bad sleep quality (SQ), difficulty initiating and maintaining sleep (DIS and DMS), early morning awakening (EMA), and daytime sleepiness. These were… Continue reading Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
Category: Neurology
Associations of #semaglutide with first-time diagnosis of #Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US
INTRODUCTIONEmerging preclinical evidence suggests that semaglutide, a glucagon-like peptide receptor agonist (GLP-1RA) for type 2 diabetes mellitus (T2DM) and obesity, protects against neurodegeneration and neuroinflammation. However, real-world evidence for its ability to protect against Alzheimer's disease (AD) is lacking.METHODSWe conducted emulation target trials based on a nationwide database of electronic health records (EHRs) of 116… Continue reading Associations of #semaglutide with first-time diagnosis of #Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US
#Acupuncture vs Sham Acupuncture for Chronic #Sciatica From Herniated Disk
Importance Sciatica is commonly caused by herniated lumbar disc and contributes to severe pain and prolonged disability. Although acupuncture is widely used by patients with chronic sciatica, the evidence of its efficacy is scarce.Objective To investigate the efficacy and safety of acupuncture compared with sham acupuncture in patients with chronic sciatica from herniated disk.Design, Settings,… Continue reading #Acupuncture vs Sham Acupuncture for Chronic #Sciatica From Herniated Disk
#Cardiac Contributions to #Brain Health: A Scientific Statement From the American Heart Association
The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Thus, achieving optimal brain health has been identified as a public health priority and a major challenge. Cardiovascular diseases are the leading cause of death and disability in the United States and around the world. Emerging evidence… Continue reading #Cardiac Contributions to #Brain Health: A Scientific Statement From the American Heart Association
#Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With Diabetes
Key PointsQuestion In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated… Continue reading #Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With Diabetes
Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
Importance Emerging evidence suggests that mild cognitive impairment, which is a precursor to Alzheimer disease and related dementias (ADRD), places older adults at increased risk for falls. However, the risk that an older adult develops dementia after experiencing a fall is unknown.Objective To determine the risk of new ADRD diagnosis after a fall in older… Continue reading Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
Comparative effects of drug interventions for the acute management of #migraine episodes in adults: systematic review and network meta-analysis
Objective To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults.Design Systematic review and network meta-analysis.Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.gov, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform, as well as websites of regulatory agencies and pharmaceutical companies without language restrictions until… Continue reading Comparative effects of drug interventions for the acute management of #migraine episodes in adults: systematic review and network meta-analysis
Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
Importance The gut-first hypothesis of Parkinson disease (PD) has gained traction, yet potential inciting events triggering Parkinson pathology from gut-related factors remain unclear. While Helicobacter pylori infection is linked to mucosal damage (MD) and PD, it is unknown how upper gastrointestinal MD from any source increases PD risk.Objective To evaluate any association between upper endoscopy findings of MD and… Continue reading Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
#Vision Impairment and the Population Attributable Fraction of #Dementia in Older Adults
Importance Vision impairment is a potentially modifiable risk factor for dementia. Although few prior studies have estimated the contribution of vision impairments to dementia, none have reported on multiple objectively measured vision impairments (eg, distance and near visual acuity and contrast sensitivity) in a nationally representative sample of older adults.Objective To quantify population attributable fractions of dementia… Continue reading #Vision Impairment and the Population Attributable Fraction of #Dementia in Older Adults
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