The authors predicted quantitatively meaningful and statistically significant variation in dementia prevalence among persons approximately age 80 according to individuals' observed characteristics when they were about age 60.An individual's baseline cognitive abilities, health, and functional limitations are the strongest predictors of dementia, whereas parental health, family size, marital history, and demographics are the weakest ones.Having… Continue reading Identifying Early Predictors of #Cognitive Impairment and Dementia in a Large Nationally Representative U.S. Sample
Category: Neurology
Use of common #cardiovascular disease drugs and risk of #dementia: A case–control study in Swedish national register data
Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case–control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia.METHODSFrom the Swedish national registers, we included 88,065 incident dementia cases aged ≥ 70 at diagnosis between 2011 and 2016 and 880,650 age- and… Continue reading Use of common #cardiovascular disease drugs and risk of #dementia: A case–control study in Swedish national register data
#Cardiovascular risk and #obesity impact loss of grey matter volume earlier in males than females
Background It remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype mediates this relationship. Here we perform a large-scale evaluation of the influence of cardiovascular risk and obesity on brain volume in males and females in different age groups.Methods 34… Continue reading #Cardiovascular risk and #obesity impact loss of grey matter volume earlier in males than females
Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
ObjectivesTo determine the association between early midlife sleep and advanced brain aging patterns in late midlife.MethodsUsing the CARDIA study, we analyzed sleep data at baseline and 5 years later, focusing on short sleep duration, bad sleep quality (SQ), difficulty initiating and maintaining sleep (DIS and DMS), early morning awakening (EMA), and daytime sleepiness. These were… Continue reading Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
Associations of #semaglutide with first-time diagnosis of #Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US
INTRODUCTIONEmerging preclinical evidence suggests that semaglutide, a glucagon-like peptide receptor agonist (GLP-1RA) for type 2 diabetes mellitus (T2DM) and obesity, protects against neurodegeneration and neuroinflammation. However, real-world evidence for its ability to protect against Alzheimer's disease (AD) is lacking.METHODSWe conducted emulation target trials based on a nationwide database of electronic health records (EHRs) of 116… Continue reading Associations of #semaglutide with first-time diagnosis of #Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US
#Acupuncture vs Sham Acupuncture for Chronic #Sciatica From Herniated Disk
Importance Sciatica is commonly caused by herniated lumbar disc and contributes to severe pain and prolonged disability. Although acupuncture is widely used by patients with chronic sciatica, the evidence of its efficacy is scarce.Objective To investigate the efficacy and safety of acupuncture compared with sham acupuncture in patients with chronic sciatica from herniated disk.Design, Settings,… Continue reading #Acupuncture vs Sham Acupuncture for Chronic #Sciatica From Herniated Disk
#Cardiac Contributions to #Brain Health: A Scientific Statement From the American Heart Association
The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Thus, achieving optimal brain health has been identified as a public health priority and a major challenge. Cardiovascular diseases are the leading cause of death and disability in the United States and around the world. Emerging evidence… Continue reading #Cardiac Contributions to #Brain Health: A Scientific Statement From the American Heart Association
#Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With Diabetes
Key PointsQuestion In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated… Continue reading #Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With Diabetes
Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
Importance Emerging evidence suggests that mild cognitive impairment, which is a precursor to Alzheimer disease and related dementias (ADRD), places older adults at increased risk for falls. However, the risk that an older adult develops dementia after experiencing a fall is unknown.Objective To determine the risk of new ADRD diagnosis after a fall in older… Continue reading Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
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