Only recently, the stigma of women using vibrators for sexual pleasure has started to fade; however, it still remains a societal taboo and is surrounded with anxiety despite a variety of potential health benefits from its use. Due to the sensitive nature of the conditions Female Pelvic Medicine and Reconstructive Surgery (FPMRS) specialists treat, they… Continue reading MP38-16 IS IT TIME FOR FPMRS TO PRESCRIBE VIBRATORS?
Category: Gynaecology
Sodium accumulation in breast cancer predicts malignancy and treatment response
BackgroundBreast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (23Na) MRI in preclinical models of breast cancer. MethodsFemale Rag2−/− Il2rg−/− and Balb/c mice bearing orthotopic breast tumours (MDA-MB-231, EMT6 and 4T1) underwent MRI as part of… Continue reading Sodium accumulation in breast cancer predicts malignancy and treatment response
Efficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women
BACKGROUNDSingle-dose human papillomavirus (HPV) vaccination, if efficacious, would be tremendously advantageous, simplifying implementation and decreasing costs. METHODSWe performed a randomized, multicenter, double-blind, controlled trial of single-dose nonavalent (HPV 16/18/31/33/45/52/58/6/11 infection) or bivalent (HPV 16/18 infection) HPV vaccination compared with meningococcal vaccination among Kenyan women 15 to 20 years of age. Enrollment and 6-monthly cervical swabs… Continue reading Efficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women
Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey
We investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID: NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the occurrence of menstrual irregularities after the first and second doses, and how long… Continue reading Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey
Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta
AbstractBisphenol A (BPA) exposure during pregnancy is associated with low fetal weight, particularly in male fetuses. The expression of estrogen-related receptor gamma (ESRRG), a receptor for BPA in the human placenta, is reduced in fetal growth restriction. This study sought to explore whether ESRRG signaling mediates BPA-induced placental dysfunction and determine whether changes in the… Continue reading Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta
MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
MYC's role in promoting tumorigenesis is beyond doubt, but its function in the metastatic process is still controversial. Omomyc is a MYC dominant negative that has shown potent antitumor activity in multiple cancer cell lines and mouse models, regardless of their tissue of origin or driver mutations, by impacting on several of the hallmarks of… Continue reading MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer
To examine the association of sedentary behavior with risk of ovarian cancer overall, by tumor subtype, and by participant characteristics in the Nurses’ Health Study (NHS) and NHSII. A total of 69,558 NHS (1992-2016) and 104,130 NHSII (1991-2015) participants were included in analysis who reported sitting time at home, work, and watching television, which included… Continue reading Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer
Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
Vaccines have been developed at “warp speed” to combat the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Although they are considered the best approach for preventing mortality, when assessing the safety of these vaccines, pregnant women have not been included in clinical trials. Thus, vaccine safety for this demographic, as well as for the developing… Continue reading Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
BackgroundDietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. MethodsData on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during… Continue reading Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
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