BackgroundThere is growing interest in identifying factors associated with healthy aging. This cross-sectional study evaluated associations of psychological resilience with factors associated with aging in older adults with type 2 diabetes mellitus (T2DM).MethodsParticipants were 3199 adults (72.2 ± 6.2 years of age, 61% female, 61% White, body mass index [BMI] = 34.2 ± 8.2 kg/m2) with T2DM enrolled in Look AHEAD (a multi-site… Continue reading Psychological resilience in older adults with type 2 diabetes from the Look AHEAD Trial
Category: Gerontology
Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults
We have developed a deep learning aging clock using blood test data from the China Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years. We used the aging clock to demonstrate the connection between the physical and psychological aspects of aging. The clock detects accelerated aging in people with heart,… Continue reading Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults
Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults
BackgroundThe hard endpoint of death is one of the most significant outcomes in both clinical practice and research settings. Our goal was to discover direct causes of longevity from medically accessible data.MethodsUsing a framework that combines local causal discovery algorithms with discovery of maximally predictive and compact feature sets (the “Markov boundaries” of the response)… Continue reading Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults
Motion, Relation, and Passion in Brain Physiological and Cognitive Aging
Abstract: The aim of the current paper was to present important factors for keeping the basic structures of a person’s brain function, i.e., the grey and white matter, intact. Several lines of evidence have shown that motion, relation, and passion are central factors for preserving the neural system in the grey and white matter during… Continue reading Motion, Relation, and Passion in Brain Physiological and Cognitive Aging
Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
Highlights•Innate immune system receptors/interferon/Stat1 axis triggers inflammaging•Both lifetime and short-time dietary restriction (DR) treatments ameliorate inflammaging•Transcriptome alteration caused by aging, lifetime, or short-term DR are tissue specific•Aging induces a general open chromatin rearrangement, which is not rescued by DRSummaryAging is characterized by a chronic low-grade inflammation known as inflammaging in multiple tissues, representing a risk… Continue reading Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment can be obtained with a brief pulse of the drug in early adulthood in female Drosophila and mice. In Drosophila, a brief, early rapamycin treatment… Continue reading Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
Association of Leisure Time Physical Activity Types and Risks of All-Cause, Cardiovascular, and Cancer Mortality Among Older Adults
Higher amounts of physical activity are associated with increased longevity. However, whether different leisure time physical activity types are differentially associated with mortality risk is not established.Objectives To examine whether participation in equivalent amounts of physical activity (7.5 to <15 metabolic equivalent of task [MET] hours per week) through different activity types is associated with… Continue reading Association of Leisure Time Physical Activity Types and Risks of All-Cause, Cardiovascular, and Cancer Mortality Among Older Adults
Projecting prevalence of frailty and dementia and the economic cost of care in Japan from 2016 to 2043: a microsimulation modelling study
Dementia and frailty often accompany one another in older age, requiring complex care and resources. Available projections provide little information on their joint impact on future health-care need from different segments of society and the associated costs. Using a newly developed microsimulation model, we forecast this situation in Japan as its population ages and decreases… Continue reading Projecting prevalence of frailty and dementia and the economic cost of care in Japan from 2016 to 2043: a microsimulation modelling study
Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age
The association between serum folate deficiency and the risk of dementia in old age is unclear, perhaps owing to small sample sizes, the competing risk of mortality or reverse causation. Objective To examine the associations between serum folate deficiency and the risks of incident dementia and all-cause mortality in a large national sample of older… Continue reading Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age
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