Gluten, which is found in cereals such as wheat, rye and barley, makes up a major dietary component in most western nations, and has been shown to promote body mass gain and peripheral inflammation in mice. In the current study, we investigated the impact of gluten on central inflammation that is typically associated with diet-induced… Continue reading Dietary wheat #gluten induces astro- and #microgliosis in the hypothalamus of male mice
Category: Endocrinology
The #fructose survival hypothesis for #obesity
The fructose survival hypothesis proposes that obesity and metabolic disorders may have developed from over-stimulation of an evolutionary-based biologic response (survival switch) that aims to protect animals in advance of crisis. The response is characterized by hunger, thirst, foraging, weight gain, fat accumulation, insulin resistance, systemic inflammation and increased blood pressure. The process is initiated by the… Continue reading The #fructose survival hypothesis for #obesity
High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
Highlights•Studies have shown that high PTH was associated with NAFLD/NASH, although the results from existing studies are inconsistent.•Using systematic review, 10 and 4 studies reported the association of PTH with NAFLD and NASH, respectively.•The meta-analysis suggested that high PTH can be a marker of NAFLD.•The meta-analysis also revealed that high PTH tended to be associated… Continue reading High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
Metformin, a first-line medication for type 2 diabetes, might also have a protective effect against ageing-related diseases, but so far little experimental evidence is available. We sought to assess the target-specific effect of metformin on biomarkers of ageing in the UK Biobank.MethodsIn this drug target mendelian randomisation study, we assessed the target-specific effect of four… Continue reading Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
#Kombucha tea as an anti-hyperglycemic agent in humans with #diabetes – a randomized controlled pilot investigation
Introduction: Kombucha is a popular fermented tea that has attracted considerable attention due, in part, to its suggested health benefits. Previous results from animal models led us to hypothesize kombucha may reduce blood sugar levels in humans with diabetes. The objective of this pilot clinical study was to evaluate kombucha for its anti-hyperglycemic activities in adults… Continue reading #Kombucha tea as an anti-hyperglycemic agent in humans with #diabetes – a randomized controlled pilot investigation
#Ultra-processed #food consumption is associated with all-cause and #cardiovascular mortality in participants with type 2 #diabetes independent of diet quality: a prospective observational cohort study
BackgroundNutritional strategies for prevention and management of type 2 diabetes traditionally emphasize dietary patterns reflecting nutrient goals, but the health implications of ultra-processed food (UPF) for patients with type 2 diabetes remain unknown.ObjectiveTo evaluate the association of UPF intake with all-cause and cardiovascular disease (CVD) mortality amongst participants with type 2 diabetes from the Moli-sani… Continue reading #Ultra-processed #food consumption is associated with all-cause and #cardiovascular mortality in participants with type 2 #diabetes independent of diet quality: a prospective observational cohort study
The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
Highlights•This is the first study to investigate the mediation effect of GMV on the association between HbA1c and depression.•Hba1c was negatively associated with GMV, and that association were stronger in prediabetic participants.•Cerebral GMV plays a mediating role on the association “HbA1c-depression”, with a proportions of 6.82%.•Effective control of glycemia can potentially prevent brain abnormality and… Continue reading The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes
The additional therapeutic effects of regular exercise during a dietary weight loss program in people with obesity and prediabetes are unclear. Here, we show that whole-body (primarily muscle) insulin sensitivity (primary outcome) was 2-fold greater (P = 0.006) after 10% weight loss induced by calorie restriction plus exercise training (Diet+EX; n = 8, 6 women) than 10% weight loss induced… Continue reading Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes
Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Adults With Insulin-Naive Type 2 DiabetesThe ONWARDS 3 Randomized Clinical Trial
Once-weekly insulin icodec could provide a simpler dosing alternative to daily basal insulin in people with type 2 diabetes.Objective To evaluate the efficacy and safety of once-weekly icodec vs once-daily insulin degludec in people with insulin-naive type 2 diabetes.Design, Setting, and Participants Randomized, double-masked, noninferiority, treat-to-target, phase 3a trial conducted from March 2021 to June 2022 at… Continue reading Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Adults With Insulin-Naive Type 2 DiabetesThe ONWARDS 3 Randomized Clinical Trial
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