..The odds ratios for myocardial infarction, heart failure, cardiovascular related death, and non-cardiovascular related death were 1.17 (0.92 to 1.51), 1.54 (1.14 to 2.09), 1.15 (0.55 to 2.41), and 1.18 (0.60 to 2.30), respectively. For analyses including trials for which IPD were not available, odds ratios for myocardial infarction and cardiovascular related death were attenuated… Continue reading Updating insights into #rosiglitazone and #cardiovascular risk through shared data: individual patient and summary level meta-analyses
Category: Cardiology
#Lifestyle Changes in Relation to Initiation of #Antihypertensive and #Lipid‐Lowering Medication: A Cohort Study
Lifestyle modification is a key component of cardiovascular disease prevention before and concurrently with pharmacologic interventions.. ..In participants who initiated medication use, body mass index increased more (difference in change 0.19; 95% CI, 0.16–0.22) and physical activity declined (−0.09 metabolic equivalent of task hour/day; 95% CI, −0.16 to −0.02) compared with noninitiators. The likelihood of… Continue reading #Lifestyle Changes in Relation to Initiation of #Antihypertensive and #Lipid‐Lowering Medication: A Cohort Study
Early onset of #menopause is associated with increased peripheral #atherosclerotic plaque volume and progression
Cardiovascular disease (CVD) is the leading cause of death in western countries. One risk factor unique to women is the menopausal status. The aim of this study was to analyse the influence of the onset of menopause (MP) on the extent and progression of atherosclerotic plaque volume (PV). ..110 consecutive postmenopausal women (mean age 65.5)… Continue reading Early onset of #menopause is associated with increased peripheral #atherosclerotic plaque volume and progression
#Pet Ownership and #Cardiovascular Health in the US general population
The 2013 American Heart Association Scientific Statement on pet ownership and cardiovascular risk suggested that dog ownership is probably associated with decreased cardiovascular risk. Several studies have been shown that pet ownership, particularly of dogs, is associated with increased physical activity levels, social support, and improved outcomes after a major cardiovascular event.. Pet owners were… Continue reading #Pet Ownership and #Cardiovascular Health in the US general population
#Marijuana Use in Patients With #Cardiovascular Disease: JACC Review Topic of the Week
Marijuana use is increasing as more states are legalizing cannabis for both medicinal and recreational purposes. National survey data estimate that >2 million Americans with established cardiovascular diseases currently use or have used marijuana in its variety of forms, including inhalation and vaping. Cannabinoid receptors are distributed in multiple tissue beds and cells, including platelets,… Continue reading #Marijuana Use in Patients With #Cardiovascular Disease: JACC Review Topic of the Week
High-#protein diets increase #cardiovascular risk by activating macrophage mTOR to suppress mitophagy
High-protein diets are commonly utilized for weight loss, yet they have been reported to raise cardiovascular risk. The mechanisms underlying this risk are unknown. Here, we show that dietary protein drives atherosclerosis and lesion complexity. Protein ingestion acutely elevates amino acid levels in blood and atherosclerotic plaques, stimulating macrophage mammalian target of rapamycin (mTOR) signalling.… Continue reading High-#protein diets increase #cardiovascular risk by activating macrophage mTOR to suppress mitophagy
Effects of #Caffeine and Acute Aerobic #Exercise on Working Memory and Caffeine Withdrawal
Studies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance.. The objectives of this study were to compare the effects of acute moderate intensity aerobic exercise to caffeine on working memory (WM) and caffeine withdrawal symptoms (CWS). In Phase I, non-caffeine… Continue reading Effects of #Caffeine and Acute Aerobic #Exercise on Working Memory and Caffeine Withdrawal
Five-Year Outcomes of Transcatheter or Surgical #Aortic-Valve Replacement
..At 5 years, there was no significant difference in the incidence of death from any cause or disabling stroke between the TAVR group and the surgery group (47.9% and 43.4%, respectively; hazard ratio, 1.09; 95% confidence interval [CI], 0.95 to 1.25; P=0.21). Results were similar for the transfemoral-access cohort (44.5% and 42.0%, respectively; hazard ratio,… Continue reading Five-Year Outcomes of Transcatheter or Surgical #Aortic-Valve Replacement
Temporal Changes in Resting #Heart Rate, Left Ventricular Dysfunction, Heart #Failure and Cardiovascular Disease: CARDIA Study
..Higher alcohol consumption (β=0.03, p<0.001), lower physical activity (β=0.002,p=001), smoking (β=1.58, p<0.001), men (p<0.001), African-Americans (p<0.001), impaired left ventricular relaxation (e´,β=-0.13, p=0.002), and worse diastolic function (E/e´,β=0.1, p=0.01) were associated with longitudinal increases in resting heart rate. We observed 268 cardiovascular disease and 74 heart failure events over a median of 26 years. In Cox… Continue reading Temporal Changes in Resting #Heart Rate, Left Ventricular Dysfunction, Heart #Failure and Cardiovascular Disease: CARDIA Study
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