Atherosclerotic coronary artery disease is the number one cause of morbidity and mortality in the United States, Europe, and Westernized countries. This review recommends a new paradigm for the reduction of atherosclerotic coronary artery disease, namely prevention and treatment by addressing the pathophysiological basis of atherosclerotic disease. This paradigm utilizes the role of cholesterol transport… Continue reading A New Paradigm to Reduce Cardiovascular #Disease Based on the Pathogenesis of #Atherosclerosis
Category: Cardiology
Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
Objectives To evaluate the effects of brief bouts of exercise spread throughout the day, termed ‘exercise snacks’, on cardiorespiratory and muscular fitness, and cardiometabolic health outcomes in physically inactive adults and older adults (aged ≥65 years).Design Systematic review and meta-analysis.Data sources Seven databases were searched from inception to April 2025.Eligibility criteria Randomised controlled trials (RCTs)… Continue reading Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
Very High Prevalence of Nonoptimally Controlled Traditional #Risk Factors at the Onset of #Cardiovascular Disease
BackgroundRecent studies suggest that coronary heart disease (CHD) may frequently occur in the absence of traditional cardiovascular disease (CVD) risk factors. However, it is unclear whether this could reflect missed clinical diagnoses or subthreshold nonoptimal risk factor exposure preceding CHD, and whether similar patterns are observed for heart failure (HF) or stroke.ObjectivesThe purpose of this… Continue reading Very High Prevalence of Nonoptimally Controlled Traditional #Risk Factors at the Onset of #Cardiovascular Disease
Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Bacterial DNA from the oral cavity, respiratory tract, gut, and skin has been detected in atherosclerotic plaques, suggesting a role in chronic inflammation linked to atherosclerosis. Chronic bacterial infections often form biofilms resistant to antibiotics and immune detection, giving rise to a new generation of virulent bacteria in suitable conditions. This study explores the role… Continue reading Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Increasing the #Potassium Level in Patients at High Risk for #Ventricular #Arrhythmias
Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular arrhythmias among patients with cardiovascular disease. An assessment of a strategy of actively increasing plasma potassium levels to the high-normal range is needed.MethodsIn this multicenter, open-label, event-driven, randomized superiority trial conducted in Denmark, we enrolled participants at high risk for ventricular arrhythmias (defined… Continue reading Increasing the #Potassium Level in Patients at High Risk for #Ventricular #Arrhythmias
#C-reactive protein and #cardiovascular risk among #women with no standard modifiable risk factors: evaluating the ‘SMuRF-less but inflamed’
Interventions in preventive cardiology traditionally focus on four standard modifiable cardiovascular risk factors (SMuRFs): hypertension, dyslipidaemia, diabetes mellitus, and smoking. Yet, a substantial proportion of incident cardiovascular events accrues for individuals with none of these factors, particularly among women for whom cardiovascular disease remains under-detected and under-treated. The utility of the inflammatory biomarker high-sensitivity C-reactive… Continue reading #C-reactive protein and #cardiovascular risk among #women with no standard modifiable risk factors: evaluating the ‘SMuRF-less but inflamed’
#Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Background and AimsRecent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF). Whether these recent findings apply equally to women and men remains unknown.MethodsUsing data from REBOOT (tREatment with Beta-blockers after myOcardial infarction withOut reduced ejection fracTion), the largest randomized trial evaluating the effect… Continue reading #Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
Psychosocial stress (PSS) is a significant contributor of inflammation and CVD.• NLRP3 inflammasome activation amplifies inflammation in response to PSS.• ER stress is a key upstream mechanism that triggers NLRP3 inflammasome activation.• This study reveals mechanisms and targets to reduce inflammation caused by PSS. AbstractPsychosocial stress (PSS) affects all humans with different intensities and is… Continue reading Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
Temporal Patterns in Out-of-Hospital #Cardiac #Arrest Incidence and Outcome
Question Is the incidence or outcome of out-of-hospital cardiac arrest (OHCA) changing over time overall or among important demographic or clinical groups?Findings In this cohort study including 25 118 individuals, temporal incidence patterns depended on rhythm and demographic characteristics, with some groups experiencing decrease, some increase, and others no change. In contrast, OHCA outcomes improved over… Continue reading Temporal Patterns in Out-of-Hospital #Cardiac #Arrest Incidence and Outcome
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