To provide multi-national, multi-ethnic data on the clinical characteristics and prognosis of patients with microvascular angina (MVA). Methods and resultsThe Coronary Vasomotor Disorders International Study Group proposed the diagnostic criteria for MVA. We prospectively evaluated the clinical characteristics of patients according to these criteria and their prognosis. The primary endpoint was the composite of major… Continue reading Clinical characteristics and prognosis of patients with microvascular #angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group
Category: Cardiology
Evidence for a causal association between #milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
High milk intake has been associated with cardio-metabolic risk. We conducted a Mendelian Randomization (MR) study to obtain evidence for the causal relationship between milk consumption and cardio-metabolic traits using the lactase persistence (LCT-13910 C > T, rs4988235) variant as an instrumental variable. MethodsWe tested the association of LCT genotype with milk consumption (for validation) and with… Continue reading Evidence for a causal association between #milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
Distinctive prognostic factor of heart #failure with preserved ejection fraction stratified with admission blood pressure
The prognostic importance of admission systolic blood pressure (SBP) in heart failure with preserved ejection fraction (HFpEF) is elusive. We aimed to clarify the pathophysiological differences between patients categorized with admission SBP among HFpEF patients. Methods and resultsWe studied 1008 inpatients from PURSUIT-HFpEF, a multicentre prospective observational registry. We classified patients as having elevated (>140… Continue reading Distinctive prognostic factor of heart #failure with preserved ejection fraction stratified with admission blood pressure
#Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease
Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in the adipose tissue (AT) metabolome is unknown. ObjectivesThe aim of this study was to explore the role of dysregulation in the AT metabolome on vascular redox signaling and cardiovascular outcomes. MethodsA screen was conducted for metabolites differentially secreted by thoracic AT… Continue reading #Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease
Associations of #cognitive performance with #cardiovascular magnetic resonance phenotypes in the UK Biobank
Existing evidence suggests links between brain and cardiovascular health. We investigated associations between cognitive performance and cardiovascular magnetic resonance (CMR) phenotypes in the UK Biobank, considering a range of potential confounders. Methods and resultsWe studied 29 763 participants with CMR and cognitive testing, specifically, fluid intelligence (FI, 13 verbal-numeric reasoning questions), and reaction time (RT, a… Continue reading Associations of #cognitive performance with #cardiovascular magnetic resonance phenotypes in the UK Biobank
Ultrasound renal #denervation for #hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial
Endovascular renal denervation reduces blood pressure in patients with mild-to-moderate hypertension, but its efficacy in patients with true resistant hypertension has not been shown. We aimed to assess the efficacy and safety of endovascular ultrasound renal denervation in patients with hypertension resistant to three or more antihypertensive medications. MethodsIn a randomised, international, multicentre, single-blind, sham-controlled… Continue reading Ultrasound renal #denervation for #hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial
Comparative Effectiveness of #Aspirin Dosing in #Cardiovascular Disease
The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy. METHODSUsing an open-label, pragmatic design, we randomly assigned patients with established atherosclerotic cardiovascular disease to a strategy of 81 mg or 325 mg… Continue reading Comparative Effectiveness of #Aspirin Dosing in #Cardiovascular Disease
#Smoking is associated with impaired verbal learning and #memory performance in women more than men
Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by exacerbating vascular disease risks. Sex disparities in VCID have been reported, however, few studies have assessed the sex-specific relationships between smoking and memory performance and… Continue reading #Smoking is associated with impaired verbal learning and #memory performance in women more than men
Prospective Case-Control Study of #Cardiovascular Abnormalities 6 Months Following Mild #COVID-19 in Healthcare Workers
ObjectivesThe purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome coronavirus 2 infection.BackgroundConcern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. MethodsParticipants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology… Continue reading Prospective Case-Control Study of #Cardiovascular Abnormalities 6 Months Following Mild #COVID-19 in Healthcare Workers
