The investigators describe antibodies that bound amyloid in three patients with transthyretin amyloidosis. Spontaneous regression of cardiomyopathy occurred in all three patients. https://www.nejm.org/doi/full/10.1056/NEJMc2304584
Category: Cardiology
Association Between Acute Myocardial Infarction and Cognition
Importance The magnitude of cognitive change after incident myocardial infarction (MI) is unclear.Objective To assess whether incident MI is associated with changes in cognitive function after adjusting for pre-MI cognitive trajectories.Design, Setting, and Participants This cohort study included adults without MI, dementia, or stroke and with complete covariates from the following US population-based cohort studies conducted from 1971… Continue reading Association Between Acute Myocardial Infarction and Cognition
Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease
Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), is the most common cause of vascular cognitive impairment, and impairs mobility and mood but has no specific treatment.Objective To test the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilostazol treatment on vascular, functional, and cognitive outcomes in… Continue reading Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease
Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
The effect of early as compared with later initiation of direct oral anticoagulants (DOACs) in persons with atrial fibrillation who have had an acute ischemic stroke is unclear.METHODSWe performed an investigator-initiated, open-label trial at 103 sites in 15 countries. Participants were randomly assigned in a 1:1 ratio to early anticoagulation (within 48 hours after a… Continue reading Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
Hysterectomy With and Without Oophorectomy, Tubal Ligation, and Risk of Cardiovascular Disease in the Nurses’ Health Study II
Backg round: Hysterectomy, oophorectomy, and tubal ligation are common surgical procedures. The literature regarding cardiovascular disease (CVD) risk after these surgeries has focused on oophorectomy with limited research on hysterectomy or tubal ligation.Materials and Methods: Participants in the Nurses' Health Study II (n = 116,429) were followed from 1989 to 2017. Self-reported gynecologic surgery was categorized as follows: no… Continue reading Hysterectomy With and Without Oophorectomy, Tubal Ligation, and Risk of Cardiovascular Disease in the Nurses’ Health Study II
Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
Background:Chronic kidney disease (CKD) accelerates vascular calcification via phenotypic switching of vascular smooth muscle cells (VSMCs). We investigated the roles of circulating small extracellular vesicles (sEVs) between the kidneys and VSMCs and uncovered relevant sEV-propagated microRNAs (miRNAs) and their biological signaling pathways.Methods and Results:We established CKD models in rats and mice by adenine-induced tubulointerstitial fibrosis.… Continue reading Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
Objective Beta-blockers (BB) are an established treatment following myocardial infarction (MI). However, there is uncertainty as to whether BB beyond the first year of MI have a role in patients without heart failure or left ventricular systolic dysfunction (LVSD).Methods A nationwide cohort study was conducted including 43 618 patients with MI between 2005 and 2016 in the Swedish… Continue reading Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study
Objective To investigate the intake of specific types of beverages in relation to mortality and cardiovascular disease (CVD) outcomes among adults with type 2 diabetes.Design Prospective cohort study.Setting Health professionals in the United States.Participants 15 486 men and women with a diagnosis of type 2 diabetes at baseline and during follow-up (Nurses’ Health Study: 1980-2018; and… Continue reading Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study
Association of Rurality With Risk of Heart Failure
Rural populations experience an increased burden of heart failure (HF) mortality compared with urban populations. Whether HF incidence is greater among rural individuals is less known. Additionally, the intersection between racial and rural health inequities is understudied.Objective To determine whether rurality is associated with increased risk of HF, independent of cardiovascular (CV) disease and socioeconomic… Continue reading Association of Rurality With Risk of Heart Failure
