INTRODUCTIONImpaired cerebrospinal fluid (CSF) dynamics may contribute to dementia, but human evidence is limited. We examined associations between magnetic resonance imaging–based proxies of CSF dynamics and incident dementia, and whether CSF dysfunction mediates links between cardiovascular risk and dementia.METHODSUsing the UK Biobank, we measured CSF dynamics: perivascular space (PVS) volume, diffusion tensor image analysis along… Continue reading MRI markers of #cerebrospinal fluid dynamics predict #dementia and mediate the impact of #cardiovascular risk
Category: Cardiology
Timing and combinations of #cardiovascular diseases in survivors of childhood, adolescent, and young adulthood #cancer
Children, adolescents, and young adults with cancer (referred to as CAYAs) are at risk of long-term health complications, with cardiovascular disease (CVD) being a major concern. In addition, sociodemographic characteristics and traditional cardiovascular risk factors may also contribute to disparities in outcomes compared with those of the general population.The aim of this study was to… Continue reading Timing and combinations of #cardiovascular diseases in survivors of childhood, adolescent, and young adulthood #cancer
Short-term association between ambient air #pollution and #heart #rate variability: results from the population-based KORA S4 and FF4 studies
Background: Ambient air pollution is a major risk factor for CVDs, and a plausible mechanism is speculated to be alteration of autonomic nervous system (ANS) function. Yet, the short-term effects of air pollution on heart rate variability (HRV), a measure of ANS balance are inconsistent.Objective: This study aimed to evaluate the short-term effects of ambient… Continue reading Short-term association between ambient air #pollution and #heart #rate variability: results from the population-based KORA S4 and FF4 studies
A New Paradigm to Reduce Cardiovascular #Disease Based on the Pathogenesis of #Atherosclerosis
Atherosclerotic coronary artery disease is the number one cause of morbidity and mortality in the United States, Europe, and Westernized countries. This review recommends a new paradigm for the reduction of atherosclerotic coronary artery disease, namely prevention and treatment by addressing the pathophysiological basis of atherosclerotic disease. This paradigm utilizes the role of cholesterol transport… Continue reading A New Paradigm to Reduce Cardiovascular #Disease Based on the Pathogenesis of #Atherosclerosis
Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
Objectives To evaluate the effects of brief bouts of exercise spread throughout the day, termed ‘exercise snacks’, on cardiorespiratory and muscular fitness, and cardiometabolic health outcomes in physically inactive adults and older adults (aged ≥65 years).Design Systematic review and meta-analysis.Data sources Seven databases were searched from inception to April 2025.Eligibility criteria Randomised controlled trials (RCTs)… Continue reading Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
Very High Prevalence of Nonoptimally Controlled Traditional #Risk Factors at the Onset of #Cardiovascular Disease
BackgroundRecent studies suggest that coronary heart disease (CHD) may frequently occur in the absence of traditional cardiovascular disease (CVD) risk factors. However, it is unclear whether this could reflect missed clinical diagnoses or subthreshold nonoptimal risk factor exposure preceding CHD, and whether similar patterns are observed for heart failure (HF) or stroke.ObjectivesThe purpose of this… Continue reading Very High Prevalence of Nonoptimally Controlled Traditional #Risk Factors at the Onset of #Cardiovascular Disease
Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Bacterial DNA from the oral cavity, respiratory tract, gut, and skin has been detected in atherosclerotic plaques, suggesting a role in chronic inflammation linked to atherosclerosis. Chronic bacterial infections often form biofilms resistant to antibiotics and immune detection, giving rise to a new generation of virulent bacteria in suitable conditions. This study explores the role… Continue reading Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Increasing the #Potassium Level in Patients at High Risk for #Ventricular #Arrhythmias
Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular arrhythmias among patients with cardiovascular disease. An assessment of a strategy of actively increasing plasma potassium levels to the high-normal range is needed.MethodsIn this multicenter, open-label, event-driven, randomized superiority trial conducted in Denmark, we enrolled participants at high risk for ventricular arrhythmias (defined… Continue reading Increasing the #Potassium Level in Patients at High Risk for #Ventricular #Arrhythmias
#C-reactive protein and #cardiovascular risk among #women with no standard modifiable risk factors: evaluating the ‘SMuRF-less but inflamed’
Interventions in preventive cardiology traditionally focus on four standard modifiable cardiovascular risk factors (SMuRFs): hypertension, dyslipidaemia, diabetes mellitus, and smoking. Yet, a substantial proportion of incident cardiovascular events accrues for individuals with none of these factors, particularly among women for whom cardiovascular disease remains under-detected and under-treated. The utility of the inflammatory biomarker high-sensitivity C-reactive… Continue reading #C-reactive protein and #cardiovascular risk among #women with no standard modifiable risk factors: evaluating the ‘SMuRF-less but inflamed’
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