This study investigated real-world edoxaban concentrations across different dosing regimens, with a specific focus on patients who met the inclusion criteria of low-dose edoxaban for the Elder Care Atrial Fibrillation (ELDERCARE-AF) trial. Patients with atrial fibrillation receiving edoxaban were enrolled to measure trough concentrations. The levels were compared with the expected therapeutic range (12–43 ng/mL) to… Continue reading Real-World #Edoxaban Concentrations in #Older Patients Receiving Reduced-Dose Regimens
Category: Cardiology
Dietary #flavanols preserve upper- and lower-limb endothelial function during #sitting in high- and low-fit young healthy males
Sedentary behaviour is very prevalent in modern societies, with young adults spending approximately 6 h/day sitting. Sitting induces declines in endothelial function, increasing the risk of cardiovascular diseases. Nutrition during sitting may be used as a strategy to minimise such effects. This acute randomised, counterbalanced, double-blinded, cross-over, placebo-controlled human study investigated whether intake of dietary… Continue reading Dietary #flavanols preserve upper- and lower-limb endothelial function during #sitting in high- and low-fit young healthy males
High-sensitivity cardiac #troponin I and risk of #dementia: the 25-year longitudinal Whitehall II study
Background and AimsThis study hypothesizes that subclinical myocardial injury during midlife, indexed by increases in cardiac troponin I, is associated with accelerated cognitive decline, smaller structural brain volume, and higher risk of dementia.MethodsOverall, 5985 participants in the Whitehall II study, aged 45–69 who had cardiac troponin I measured by a high-sensitivity assay at baseline (1997–99),… Continue reading High-sensitivity cardiac #troponin I and risk of #dementia: the 25-year longitudinal Whitehall II study
Association between frequency of meeting daily step thresholds and all-cause #mortality and #cardiovascular disease in older women
Objective To examine the associations between the number of days per week achieving various daily step thresholds and all-cause mortality and cardiovascular disease (CVD) incidence in older women.Methods We conducted a prospective cohort study of 13 547 women free of CVD and cancer (mean age 71.8 years). We included participants who wore an ActiGraph GT3X+ accelerometer for… Continue reading Association between frequency of meeting daily step thresholds and all-cause #mortality and #cardiovascular disease in older women
MRI markers of #cerebrospinal fluid dynamics predict #dementia and mediate the impact of #cardiovascular risk
INTRODUCTIONImpaired cerebrospinal fluid (CSF) dynamics may contribute to dementia, but human evidence is limited. We examined associations between magnetic resonance imaging–based proxies of CSF dynamics and incident dementia, and whether CSF dysfunction mediates links between cardiovascular risk and dementia.METHODSUsing the UK Biobank, we measured CSF dynamics: perivascular space (PVS) volume, diffusion tensor image analysis along… Continue reading MRI markers of #cerebrospinal fluid dynamics predict #dementia and mediate the impact of #cardiovascular risk
Timing and combinations of #cardiovascular diseases in survivors of childhood, adolescent, and young adulthood #cancer
Children, adolescents, and young adults with cancer (referred to as CAYAs) are at risk of long-term health complications, with cardiovascular disease (CVD) being a major concern. In addition, sociodemographic characteristics and traditional cardiovascular risk factors may also contribute to disparities in outcomes compared with those of the general population.The aim of this study was to… Continue reading Timing and combinations of #cardiovascular diseases in survivors of childhood, adolescent, and young adulthood #cancer
Short-term association between ambient air #pollution and #heart #rate variability: results from the population-based KORA S4 and FF4 studies
Background: Ambient air pollution is a major risk factor for CVDs, and a plausible mechanism is speculated to be alteration of autonomic nervous system (ANS) function. Yet, the short-term effects of air pollution on heart rate variability (HRV), a measure of ANS balance are inconsistent.Objective: This study aimed to evaluate the short-term effects of ambient… Continue reading Short-term association between ambient air #pollution and #heart #rate variability: results from the population-based KORA S4 and FF4 studies
A New Paradigm to Reduce Cardiovascular #Disease Based on the Pathogenesis of #Atherosclerosis
Atherosclerotic coronary artery disease is the number one cause of morbidity and mortality in the United States, Europe, and Westernized countries. This review recommends a new paradigm for the reduction of atherosclerotic coronary artery disease, namely prevention and treatment by addressing the pathophysiological basis of atherosclerotic disease. This paradigm utilizes the role of cholesterol transport… Continue reading A New Paradigm to Reduce Cardiovascular #Disease Based on the Pathogenesis of #Atherosclerosis
Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
Objectives To evaluate the effects of brief bouts of exercise spread throughout the day, termed ‘exercise snacks’, on cardiorespiratory and muscular fitness, and cardiometabolic health outcomes in physically inactive adults and older adults (aged ≥65 years).Design Systematic review and meta-analysis.Data sources Seven databases were searched from inception to April 2025.Eligibility criteria Randomised controlled trials (RCTs)… Continue reading Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
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