Background: Iron deficiency (ID) is a common comorbidity in patients with heart failure (HF) and is associated with reduced functional capacity, diminished quality of life, and increased mortality. This study aimed to determine the prevalence of ID and its clinical characteristics.Methods: This descriptive cross-sectional study involved 136 patients with chronic HF at the University of… Continue reading Clinical Characteristics of Iron Deficiency in Patients with Chronic Heart Failure at a Major Referral Centre in Southern Nigeria
Category: Cardiology
Fecal Incontinence as a Marker of Multisystem Cardiopulmonary-Kidney Disease and Mortality in US Adults: : A Nationally Representative Cohort Study
Objective: To determine whether fecal incontinence is associated with cardiovascular, pulmonary, and kidney disease, individually and in combination, and with all-cause mortality among community-dwelling US adults.Methods: Nationally representative cohort study using the National Health and Nutrition Examination Survey (NHANES) 2005-2010 with linkage to the National Death Index through December 31, 2019. The analytic cohort comprised… Continue reading Fecal Incontinence as a Marker of Multisystem Cardiopulmonary-Kidney Disease and Mortality in US Adults: : A Nationally Representative Cohort Study
Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications
Valvular cardiomyopathy has emerged as a key concept linking valvular heart disease (VHD) with myocardial remodeling and the development of heart failure (HF). This state-of-the-art review provides a comprehensive overview of pathophysiological mechanisms, multimodality imaging, and implication for valve interventions across the spectrum of VHD. We systematically address HF in the context of aortic valve… Continue reading Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications
Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome
Homocysteine (HCY) has been implicated in cardiovascular disease through adverse effects on vascular endothelium, oxidative stress, and thrombogenic pathways. Saudi Arabia has a young population and an increasing burden of cardiovascular disease, yet regional data on HCY and B-vitamin profiles in premature acute coronary syndrome (ACS) remain limited. This single-center cross-sectional exploratory study evaluated serum… Continue reading Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome
Oxygen cost of breathing and its association with dyspnea in older patients with heart failure with preserved ejection fraction and obesity
Introduction: Obesity is associated with an increased oxygen (O2) cost of breathing, which could contribute to dyspnea on exertion (DOE) and exercise intolerance. Many patients with heart failure with preserved ejection fraction (HFpEF) also have obesity, but whether an elevated O2 cost of breathing contributes to DOE and exercise intolerance in these patients is unclear.… Continue reading Oxygen cost of breathing and its association with dyspnea in older patients with heart failure with preserved ejection fraction and obesity
Effect of Statin Therapy on Clinical Outcomes in Patients With Cardiovascular Risks: A Systematic Review and Meta-Analysis
Statin therapy effectively reduces low-density lipoprotein (LDL) cholesterol, thereby lowering the risk of atherosclerosis and cardiovascular (CV) events. This systematic review and meta-analysis assessed its impact on all-cause mortality, CV mortality, major adverse cardiovascular events (MACE), such as heart attack, stroke, coronary revascularization, and CV hospitalization in adults with CV risk factors or established cardiovascular… Continue reading Effect of Statin Therapy on Clinical Outcomes in Patients With Cardiovascular Risks: A Systematic Review and Meta-Analysis
Full- vs Reduced-Dose Direct Oral Anticoagulants for Extended Treatment of Cancer-Associated Thrombosis: A Multicenter Retrospective Cohort Study
Extended anticoagulation is recommended in subjects with cancer-associated thrombosis (CAT). The API-CAT trial showed that reduced-dose apixaban is noninferior to full-dose for preventing recurrent venous thromboembolism (VTE), but the generalizability of these findings to real-world populations remains to be determined. We conducted a multicenter retrospective cohort study including patients with CAT receiving extended direct oral… Continue reading Full- vs Reduced-Dose Direct Oral Anticoagulants for Extended Treatment of Cancer-Associated Thrombosis: A Multicenter Retrospective Cohort Study
Semaglutide for Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Patients with Type 2 Diabetes and Comorbid Rheumatoid Arthritis: A Target-Trial Emulation
Background: Rheumatoid arthritis (RA)-related physical limitations often hinder sustained physical activity and weight management, thereby amplifying cardiovascular risk through adverse metabolic profiles and chronic inflammation. We aimed to assess the effectiveness of semaglutide on the risk of incident major adverse cardiovascular and cerebrovascular events (MACCE) in obese adults with type 2 diabetes mellitus (T2DM) and… Continue reading Semaglutide for Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Patients with Type 2 Diabetes and Comorbid Rheumatoid Arthritis: A Target-Trial Emulation
Degree of urbanization and the prevalence of hypertension and diabetes mellitus in South Korea (Insight from Gyeonggi Province): A cross-sectional analysis with temporal trends, 2008-2023
Background: Despite South Korea's achievement of Universal Health Coverage (UHC), regional health inequities persist as a significant public health challenge. Traditional urban-rural classifications often fail to capture the nuanced spatial dynamics of modern settlement patterns. This study aimed to evaluate the prevalence of hypertension (HTN) and diabetes mellitus (DM) across the urbanization gradient-Cities, Urbanized, and… Continue reading Degree of urbanization and the prevalence of hypertension and diabetes mellitus in South Korea (Insight from Gyeonggi Province): A cross-sectional analysis with temporal trends, 2008-2023
