There is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, #cardiovascular disease, #cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
Category: Cardiology
A terminal metabolite of niacin promotes vascular inflammation and contributes to #cardiovascular disease risk
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD risk remains even for individuals receiving all guideline-recommended interventions. Niacin is an essential micronutrient fortified in food staples, but its role in CVD is not well understood. In this study, untargeted metabolomics analysis of fasting plasma from stable cardiac patients in a prospective discovery cohort… Continue reading A terminal metabolite of niacin promotes vascular inflammation and contributes to #cardiovascular disease risk
#Autopsy findings in cases of fatal #COVID-19 #vaccine -induced #myocarditis
COVID-19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID-19 vaccines and death from myocarditis using post-mortem analysis. We performed a systematic review of all published autopsy reports involving COVID-19 vaccination-induced myocarditis through 3 July 2023. All autopsy studies that… Continue reading #Autopsy findings in cases of fatal #COVID-19 #vaccine -induced #myocarditis
#Statins and risks of #dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong
Heart failure (HF) and dementia frequently co-exist with shared pathological mechanisms and risk factors. Our study aims to investigate the association between statin therapy and the risks of dementia and its subtypes among patients with HF.MethodsThe Hong Kong Clinical Data Analysis and Reporting System database was interrogated to identify patients with incident HF diagnosis from… Continue reading #Statins and risks of #dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong
Abstract 13719: Minimal and Delayed Age-Related Increase of Arterial #Stiffness Among Tsimane Forager-Horticulturalists
Background: Tsimane forager-farmers of the Bolivian Amazon exhibit a distinct trajectory of vascular aging, characterized by low age-related increases in BP, the lowest levels of coronary calcification ever reported, and robust VO2 max. However, the prevalence of arterial stiffness (ArSt) in this population and its association with age and other cardiovascular risk factors are unknown.Methods: Large artery elasticity… Continue reading Abstract 13719: Minimal and Delayed Age-Related Increase of Arterial #Stiffness Among Tsimane Forager-Horticulturalists
Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
Dietary circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohortDaily eating/fasting cycles synchronise circadian peripheral clocks, involved in the regulation of the cardiovascular system. However, the associations of daily meal and fasting timing with cardiovascular disease (CVD) incidence remain unclear. We used data from 103,389 adults in the NutriNet-Santé study. Meal timing and… Continue reading Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
#Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
Although hormone therapy (HT) in perimenopausal women is associated with increased risk for venous thromboembolism (VTE), it is unclear to what extent statins may mitigate this HT-associated risk.Objective To estimate VTE risk in women aged 50 to 64 years taking HT with or without statins.Design, Setting, and Participants This nested case-control study analyzed data from a commercially… Continue reading #Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and… Continue reading Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
Relationship of Daily #Step Counts to All-Cause #Mortality and #Cardiovascular Events
Background The minimal and optimal daily step counts for health improvements remain unclear. Objectives A meta-analysis was performed to quantify dose-response associations of objectively measured step count metrics in the general population. Methods Electronic databases were searched from inception to October 2022. Primary outcomes included all-cause mortality and incident cardiovascular disease (CVD). Study results were… Continue reading Relationship of Daily #Step Counts to All-Cause #Mortality and #Cardiovascular Events
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