Importance Menopause is associated with biological aging, and hormone therapy (HT) is associated with health outcomes in postmenopausal women.Objective To evaluate the association between HT use and discrepancies between chronological and biological age in postmenopausal women as well as the potential modifying role of socioeconomic status (SES).Design, Setting, and Participants This population-based, retrospective cohort study included postmenopausal women… Continue reading #Hormone Therapy and Biological #Aging in Postmenopausal Women
Category: Aging
#Accelerometer-derived ‘weekend warrior’ physical #activity pattern and #brain health
Extensive evidence shows the beneficial effect of adhering to a regular physical activity (PA) pattern on brain health. However, whether the ‘weekend warrior’ pattern, characterized by concentrated moderate-to-vigorous PA (MVPA) over 1–2 days, is associated with brain health is unclear. Here, we perform a prospective cohort study including 75,629 participants from the UK Biobank with validated… Continue reading #Accelerometer-derived ‘weekend warrior’ physical #activity pattern and #brain health
#Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart… Continue reading #Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
Effect of long-term #caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad-libitum (AL) control (2:1) for 2 years. Prior… Continue reading Effect of long-term #caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
#Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.Objective To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.Design, Setting, and Participants This large-scale,… Continue reading #Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
#Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
AbstractObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.MethodsWe analyzed Framingham Offspring Cohort data. We included participants ≥60 years-old, free of dementia and having dietary,… Continue reading #Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
#Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study… Continue reading #Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
OXR1 maintains the retromer to delay brain #aging under #dietary restriction
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids.… Continue reading OXR1 maintains the retromer to delay brain #aging under #dietary restriction
The Importance of Consistent Sleep Habits in Slowing Down the Aging Process
Consistent Sleep Habits Shown to Slow Down Aging Process, Study Finds A recent study conducted by researchers at Augusta University in the United States has revealed the significant impact of maintaining consistent sleep habits on overall health and aging. The findings suggest that a regular sleep routine not only benefits cognitive processes such as thinking… Continue reading The Importance of Consistent Sleep Habits in Slowing Down the Aging Process
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