AbstractObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.MethodsWe analyzed Framingham Offspring Cohort data. We included participants ≥60 years-old, free of dementia and having dietary,… Continue reading #Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
Category: Aging
#Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study… Continue reading #Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
OXR1 maintains the retromer to delay brain #aging under #dietary restriction
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids.… Continue reading OXR1 maintains the retromer to delay brain #aging under #dietary restriction
The Importance of Consistent Sleep Habits in Slowing Down the Aging Process
Consistent Sleep Habits Shown to Slow Down Aging Process, Study Finds A recent study conducted by researchers at Augusta University in the United States has revealed the significant impact of maintaining consistent sleep habits on overall health and aging. The findings suggest that a regular sleep routine not only benefits cognitive processes such as thinking… Continue reading The Importance of Consistent Sleep Habits in Slowing Down the Aging Process
Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
AbstractAbdominal fat is increasingly linked to brain health. A total of 10,001 healthy participants were scanned on 1.5T MRI with a short whole-body MR imaging protocol. Deep learning with FastSurfer segmented 96 brain regions. Separate models segmented visceral and subcutaneous abdominal fat. Regression analyses of abdominal fat types and normalized brain volumes were evaluated, controlling… Continue reading Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
Metformin, a first-line medication for type 2 diabetes, might also have a protective effect against ageing-related diseases, but so far little experimental evidence is available. We sought to assess the target-specific effect of metformin on biomarkers of ageing in the UK Biobank.MethodsIn this drug target mendelian randomisation study, we assessed the target-specific effect of four… Continue reading Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
Low-Dose #Aspirin and the Risk of #Stroke and Intracerebral #Bleeding in Healthy Older People Secondary Analysis of a Randomized Clinical Trial
Low-dose aspirin has been widely used for primary and secondary prevention of stroke. The balance between potential reduction of ischemic stroke events and increased intracranial bleeding has not been established in older individuals.Objective To establish the risks of ischemic stroke and intracranial bleeding among healthy older people receiving daily low-dose aspirin.Design, Setting, and Participants This secondary analysis… Continue reading Low-Dose #Aspirin and the Risk of #Stroke and Intracerebral #Bleeding in Healthy Older People Secondary Analysis of a Randomized Clinical Trial
#Constipation Associated with #Cognitive #Aging and Decline
Key Takeaways:Chronic constipation — one bowel movement every three days or more — could signal worsening cognition.People who were chronically constipated had worse cognition equal to three years of aging, according to the study, which is the first to look at constipation’s potential impact on the aging brain.The new findings add to mounting research aligning… Continue reading #Constipation Associated with #Cognitive #Aging and Decline
Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status
Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated the association between 20-year exposure to greenness [Normalized Difference Vegetation Index (NDVI)] and epigenetic aging in a large, biracial (Black/white), U.S. urban cohort. Using generalized estimating equations adjusted for… Continue reading Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status
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