Primary Sjögren's syndrome (pSS), a chronic autoimmune disorder primarily affecting the exocrine glands, typically presents with sicca symptoms. Neurological involvement in pSS is uncommon as an initial presentation. Ischemic stroke, in particular, is a rare manifestation, while seizures are more commonly secondary to underlying structural or inflammatory central nervous system involvement. Here, we report a… Continue reading Ischemic Stroke as a Possible Initial Manifestation of Primary Sjögren’s Syndrome: A Case Report
Category: Neurology
Validity and reliability of the Turkish version of the early symptom measurement of post-stroke depression short form (ESMPSD-SF)
The present methodological study was conducted to adapt the Early Symptom Measurement of Post-Stroke Depression developed by Li et al.1 into Turkish and to examine its validity and reliability. This study was conducted between September and December 2025 with a final sample of 120 patients diagnosed with stroke. Data were collected using a Personal Information… Continue reading Validity and reliability of the Turkish version of the early symptom measurement of post-stroke depression short form (ESMPSD-SF)
Chaos in the Equilibrium: A Rare Complication of Dialysis
Dialysis disequilibrium syndrome (DDS) is a rare but potentially life-threatening neurologic complication associated with hemodialysis (HD), particularly during initial treatments in patients with severe uremia. It is thought to result from rapid osmotic shifts between the plasma and the central nervous system during dialysis. We present the case of a 36-year-old woman with stage V… Continue reading Chaos in the Equilibrium: A Rare Complication of Dialysis
Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling
Growth/differentiation factor–15 (GDF15) is a secreted cytokine strongly associated with dementia risk. However, the extent to which GDF15 represents a biomarker and driver of dementia risk remains unclear. Across multiple cohorts, we demonstrated that plasma GDF15 is associated with greater dementia risk over 15- to 25-year follow-up periods when measured in midlife, with stronger associations… Continue reading Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling
Prenatal exposure to particulate matter and risk of autism spectrum disorder in children: a population-based cohort study in South Korea
Background: Prenatal exposure to particulate matter has been investigated as a potential environmental factor for autism spectrum disorder (ASD), but evidence remains heterogeneous, and nationwide data from non-Western populations are limited.Methods: We conducted a nationwide retrospective birth cohort study using the Big CHildren's ENvironmental health Study (Big-CHENS) database in South Korea, including 698,907 mother-father-child pairs… Continue reading Prenatal exposure to particulate matter and risk of autism spectrum disorder in children: a population-based cohort study in South Korea
Evaluating emerging amyloid-β centric drugs for the treatment of Alzheimer’s disease
Introduction: The #amyloid cascade hypothesis provided a compelling rationale for #Alzheimer's disease (AD) drug development, but many amyloid-β (Aβ)-targeted agents failed to show benefit. The present review article evaluated emerging Aβ-directed therapies, focusing on mechanisms, clinical efficacy, safety, and regulatory progress.Areas covered: The recent approvals of lecanemab and donanemab offered the first convincing evidence that… Continue reading Evaluating emerging amyloid-β centric drugs for the treatment of Alzheimer’s disease
Prognostic value of C-reactive protein to albumin ratio for in-hospital mortality in acute stroke patients
Background: This study aimed to evaluate the prognostic significance of the C-reactive protein to albumin ratio (CAR) in predicting in-hospital #mortality among patients presenting with acute #stroke.Method: A total of 483 adult patients (≥ 18 years) consecutively hospitalized for stroke over a one-year period (July 2022 - July 2023) were analyzed retrospectively. Exclusion criteria include… Continue reading Prognostic value of C-reactive protein to albumin ratio for in-hospital mortality in acute stroke patients
Multikingdom microbiome-based machine learning enables multiple sclerosis diagnosis
Emerging evidence suggests a role for the gut bacteria in the pathogenesis of multiple sclerosis (#MS ); however, the role of other microorganisms and their diagnostic potential for MS remain poorly explored. Here, we analyzed large-scale metagenomic data derived from fecal samples (discovery cohort n = 1152; total n = 1306 across 3 geographically diverse… Continue reading Multikingdom microbiome-based machine learning enables multiple sclerosis diagnosis
Reversible alterations of brain acetate metabolism associated with alcohol consumption
#Alcohol consumption elevates circulating acetate. Prior studies showed that acute alcohol reduces brain glucose uptake and increases #brain acetate oxidation. Previously we showed that heavy drinkers have elevated capacity to oxidize brain acetate. Here we repeat the study, adding individuals with alcohol use disorder (AUD). Four groups were enrolled. The analysis data set included Light… Continue reading Reversible alterations of brain acetate metabolism associated with alcohol consumption
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