#Alcohol consumption elevates circulating acetate. Prior studies showed that acute alcohol reduces brain glucose uptake and increases #brain acetate oxidation. Previously we showed that heavy drinkers have elevated capacity to oxidize brain acetate. Here we repeat the study, adding individuals with alcohol use disorder (AUD). Four groups were enrolled. The analysis data set included Light… Continue reading Reversible alterations of brain acetate metabolism associated with alcohol consumption
Category: Neurology
Pilot evaluation of a dance-based physical activity program for adults with Down syndrome
Introduction: Adults with #Down syndrome (DS) face barriers to traditional exercise modalities due in part to a lack of interest or enjoyment, desire for social connectedness during exercise, and difficulty completing traditional exercise movements because of physical limitations. Dance provides a potential alternative to conventional exercise and may address some of these barriers. The purpose… Continue reading Pilot evaluation of a dance-based physical activity program for adults with Down syndrome
Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Background: Acute myocardial infarction (#MI ) is associated with subsequent #cognitive decline. Whether the detection of prior MI using routine ECG and self-reported history can identify different trajectories of cognitive decline is uncertain. We sought to determine the association between prior MI and longitudinal cognitive assessments within a national, biracial cohort study.Methods: We included participants… Continue reading Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Health behavior mechanisms linking childhood socioeconomic status to Alzheimer’s disease and related dementia risk: Exploring gender and racial/ethnic differences
,BackgroundLower childhood #socioeconomic status (cSES) has been linked to a higher risk of #Alzheimer's disease and related #dementia (ADRD). Yet, the mechanisms underlying this association remain unclear.ObjectiveThis study examined whether poorer health behaviors in adulthood mediate the association between lower cSES and ADRD risk. We further explored whether the mediating effects of health behaviors vary… Continue reading Health behavior mechanisms linking childhood socioeconomic status to Alzheimer’s disease and related dementia risk: Exploring gender and racial/ethnic differences
Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy
Aims: Although pregabalin is a first-line therapy for painful #diabetic #polyneuropathy (PDPN), its optimal dose-response relationship remains unclear. We conducted a network meta-analysis to evaluate the efficacy and safety of fixed pregabalin dosages in PDPN patients.Materials and methods: We systematically searched major databases through October 2025 comparing various doses of pregabalin (75, 150, 300, and… Continue reading Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy
Clinical effect of acupuncture on dysphagia following traumatic brain injury based on fiberoptic endoscopic evaluation of swallowing
Objectives: To investigate the clinical therapeutic effect on #dysphagia following traumatic #brain injury (TBI) treated with acupuncture using fiberoptic endoscopic evaluation of swallowing (FEES).Methods: A total of 68 patients with dysphagia following TBI were enrolled and randomly divided into a control group and an acupuncture group, with 34 patients in each group. In the control… Continue reading Clinical effect of acupuncture on dysphagia following traumatic brain injury based on fiberoptic endoscopic evaluation of swallowing
Cardiac-related symptoms in individuals aged ≥65 years without diagnosed cardiac disease: insights from the NORSCREEN trial
Aims: Population-based data on cardiac-related symptoms in individuals without diagnosed #cardiac disease remain limited, despite important implications for early detection and management. We aimed to assess the prevalence of self-reported symptoms and the association with quality of life (QoL) among adults aged ≥65 years with ≥1 additional stroke risk factor, but without diagnosed cardiac disease.Methods… Continue reading Cardiac-related symptoms in individuals aged ≥65 years without diagnosed cardiac disease: insights from the NORSCREEN trial
Perioperative Best Practices and Delirium in Patients With Cognitive Impairment
Importance: Despite substantial advances in #perioperative care, patients with #cognitive impairment are at increased risk for postoperative delirium. Understanding the association of perioperative best practices with delirium prevention may inform tailored strategies for this high-risk group.Objective: To examine associations between anesthesia-related best practices and postoperative delirium in patients with cognitive impairment.Design, setting, and participants: This… Continue reading Perioperative Best Practices and Delirium in Patients With Cognitive Impairment
Effect of Continuous Perioperative Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Randomized Controlled Trial
Purpose: To investigate the effect of perioperative continuous TEAS on the incidence of POD in elderly patients undergoing laparoscopic gastrointestinal surgery.Patients and methods: In this prospective, double-blind, randomized controlled trial, 180 elderly patients (age ≥65 years, ASA I-III) scheduled for laparoscopic gastrointestinal #surgery were randomized into three groups: Group A received continuous TEAS (n=60), Group… Continue reading Effect of Continuous Perioperative Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Randomized Controlled Trial
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