Growth/differentiation factor–15 (GDF15) is a secreted cytokine strongly associated with dementia risk. However, the extent to which GDF15 represents a biomarker and driver of dementia risk remains unclear. Across multiple cohorts, we demonstrated that plasma GDF15 is associated with greater dementia risk over 15- to 25-year follow-up periods when measured in midlife, with stronger associations… Continue reading Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling
Category: Neurology
Prenatal exposure to particulate matter and risk of autism spectrum disorder in children: a population-based cohort study in South Korea
Background: Prenatal exposure to particulate matter has been investigated as a potential environmental factor for autism spectrum disorder (ASD), but evidence remains heterogeneous, and nationwide data from non-Western populations are limited.Methods: We conducted a nationwide retrospective birth cohort study using the Big CHildren's ENvironmental health Study (Big-CHENS) database in South Korea, including 698,907 mother-father-child pairs… Continue reading Prenatal exposure to particulate matter and risk of autism spectrum disorder in children: a population-based cohort study in South Korea
Evaluating emerging amyloid-β centric drugs for the treatment of Alzheimer’s disease
Introduction: The #amyloid cascade hypothesis provided a compelling rationale for #Alzheimer's disease (AD) drug development, but many amyloid-β (Aβ)-targeted agents failed to show benefit. The present review article evaluated emerging Aβ-directed therapies, focusing on mechanisms, clinical efficacy, safety, and regulatory progress.Areas covered: The recent approvals of lecanemab and donanemab offered the first convincing evidence that… Continue reading Evaluating emerging amyloid-β centric drugs for the treatment of Alzheimer’s disease
Prognostic value of C-reactive protein to albumin ratio for in-hospital mortality in acute stroke patients
Background: This study aimed to evaluate the prognostic significance of the C-reactive protein to albumin ratio (CAR) in predicting in-hospital #mortality among patients presenting with acute #stroke.Method: A total of 483 adult patients (≥ 18 years) consecutively hospitalized for stroke over a one-year period (July 2022 - July 2023) were analyzed retrospectively. Exclusion criteria include… Continue reading Prognostic value of C-reactive protein to albumin ratio for in-hospital mortality in acute stroke patients
Multikingdom microbiome-based machine learning enables multiple sclerosis diagnosis
Emerging evidence suggests a role for the gut bacteria in the pathogenesis of multiple sclerosis (#MS ); however, the role of other microorganisms and their diagnostic potential for MS remain poorly explored. Here, we analyzed large-scale metagenomic data derived from fecal samples (discovery cohort n = 1152; total n = 1306 across 3 geographically diverse… Continue reading Multikingdom microbiome-based machine learning enables multiple sclerosis diagnosis
Reversible alterations of brain acetate metabolism associated with alcohol consumption
#Alcohol consumption elevates circulating acetate. Prior studies showed that acute alcohol reduces brain glucose uptake and increases #brain acetate oxidation. Previously we showed that heavy drinkers have elevated capacity to oxidize brain acetate. Here we repeat the study, adding individuals with alcohol use disorder (AUD). Four groups were enrolled. The analysis data set included Light… Continue reading Reversible alterations of brain acetate metabolism associated with alcohol consumption
Pilot evaluation of a dance-based physical activity program for adults with Down syndrome
Introduction: Adults with #Down syndrome (DS) face barriers to traditional exercise modalities due in part to a lack of interest or enjoyment, desire for social connectedness during exercise, and difficulty completing traditional exercise movements because of physical limitations. Dance provides a potential alternative to conventional exercise and may address some of these barriers. The purpose… Continue reading Pilot evaluation of a dance-based physical activity program for adults with Down syndrome
Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Background: Acute myocardial infarction (#MI ) is associated with subsequent #cognitive decline. Whether the detection of prior MI using routine ECG and self-reported history can identify different trajectories of cognitive decline is uncertain. We sought to determine the association between prior MI and longitudinal cognitive assessments within a national, biracial cohort study.Methods: We included participants… Continue reading Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Health behavior mechanisms linking childhood socioeconomic status to Alzheimer’s disease and related dementia risk: Exploring gender and racial/ethnic differences
,BackgroundLower childhood #socioeconomic status (cSES) has been linked to a higher risk of #Alzheimer's disease and related #dementia (ADRD). Yet, the mechanisms underlying this association remain unclear.ObjectiveThis study examined whether poorer health behaviors in adulthood mediate the association between lower cSES and ADRD risk. We further explored whether the mediating effects of health behaviors vary… Continue reading Health behavior mechanisms linking childhood socioeconomic status to Alzheimer’s disease and related dementia risk: Exploring gender and racial/ethnic differences
