Lipid metabolism, coagulation, inflammation, and vascular integrity are closely interconnected biological systems. Although statins are primarily prescribed to reduce low-density lipoprotein cholesterol (LDL-C) and prevent atherosclerotic cardiovascular disease, increasing evidence indicates that these agents exert multiple pharmacological effects beyond lipid lowering, including modulation of endothelial function, platelet activation, tissue factor expression, thrombin generation, fibrinolysis, and… Continue reading Lipid Metabolism, Statins and Bleeding Risk During Anticoagulant Therapy: Emerging Pharmacological Insights
Category: Cardiology
Is Ferroptosis and Oxidative Stress Involved in NSTEMI Patient’s?
Highlights: Ferroptosis (iron-dependent lipid peroxidation-driven cell death) is implicated in ischemic injury.NSTEMI patients showed significantly higher oxidative stress (↑LPO) and iron overload (↑iron, ↑ferritin) vs controls.Antioxidant defenses were reduced in NSTEMI (↓TAC, ↓TTG, ↓SOD, ↓GPx activity).This biomarker pattern supports ferroptosis activation contributing to myocardial injury in NSTEMI.Background: Ischemic heart disease is the leading cause of… Continue reading Is Ferroptosis and Oxidative Stress Involved in NSTEMI Patient’s?
Clinical Vulnerability Refines Rhythm-Related Outcomes in Older Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation: An Observational Cohort Study
Introduction: Chronological age is often considered when selecting patients for atrial fibrillation (AF) ablation, but age alone may not identify which older patients are most likely to require recurrent rhythm-related care after pulmonary vein isolation (PVI).Methods: We conducted a single-center observational study of consecutive patients undergoing PVI. The principal registry cohort assessed the same-center recurrence-related… Continue reading Clinical Vulnerability Refines Rhythm-Related Outcomes in Older Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation: An Observational Cohort Study
Association of isolated systolic and diastolic hypertension with moderately increased albuminuria: the Korea National Health and Nutrition Examination Survey
Background: Studies show variable results on health outcomes of isolated diastolic hypertension (IDH); however, data are scarce on its association with early kidney injury.Methods: We analyzed the Korea National Health and Nutrition Examination Survey data (2011-2014 and 2019-2024) in adults ≥19 years. After excluding those taking antihypertensive medication or with established kidney disease, participants were… Continue reading Association of isolated systolic and diastolic hypertension with moderately increased albuminuria: the Korea National Health and Nutrition Examination Survey
The Incretin Revolution: Integrating Incretin-Based Therapies into Clinical Care
Incretin-based therapies have changed the landscape of modern medical practice. Obesity-related disease processes including type 2 diabetes mellitus, cardiovascular disease, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease, and obstructive sleep apnea improve in patients treated with these medications, and several now carry organ-specific regulatory indications. In this narrative review we summarize the mechanisms through… Continue reading The Incretin Revolution: Integrating Incretin-Based Therapies into Clinical Care
Ultrashort vs Standard-Duration Dual Antiplatelet Therapy in Acute Coronary Syndrome Patients Undergoing PCI: A Meta-Analysis
Background: The efficacy and safety of ultrashort (≤1-month) dual antiplatelet therapy (DAPT) followed by antiplatelet monotherapy remain uncertain in acute coronary syndrome (ACS) patients.Objectives: This study sought to compare ultrashort vs standard-duration DAPT in patients with ACS undergoing percutaneous coronary intervention (PCI).Methods: We conducted a systematic review and meta-analysis of randomized controlled trials until February… Continue reading Ultrashort vs Standard-Duration Dual Antiplatelet Therapy in Acute Coronary Syndrome Patients Undergoing PCI: A Meta-Analysis
Mechanical complications of transcatheter aortic valve replacement: a review article
Aortic stenosis (AS) represents a prevalent valvular heart disease, particularly affecting the elderly population, with substantial implications for morbidity and mortality. This review examines the epidemiology, pathophysiology, management strategies, complications, and future implications of AS and its treatment modalities, focusing primarily on transcatheter aortic valve replacement (TAVR). The prevalence of AS is rising as the… Continue reading Mechanical complications of transcatheter aortic valve replacement: a review article
Cardiovascular-Kidney-Metabolic Syndrome Age Derived From Routine Health Checkup and Claims Data – Large-Scale Epidemiological Study
Background: The cardiovascular-kidney-metabolic (CKM) framework emphasizes the interplay of metabolic, renal, and cardiovascular abnormalities in cardiovascular disease risk. We aimed to develop a CKM syndrome age algorithm using routinely collected health checkup and claims data in Japan.Methods and results: We conducted a cohort study of 376,612 men and 478,853 women aged 20-79 years in the… Continue reading Cardiovascular-Kidney-Metabolic Syndrome Age Derived From Routine Health Checkup and Claims Data – Large-Scale Epidemiological Study
Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Background: Patients with atrial fibrillation (AF) who are at increased risk of both thrombotic and haemorrhagic events represent a heterogeneous and broad clinical entity, characterized by the presence of several Janus-faced risk factors. We aimed to identify clinical phenotypes and assess the association of ABC pathway adherence with one-year outcomes in patients with AF at… Continue reading Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
